Going forward, we need combined approaches to track all sorts of viruses & microbes that threaten our health & our economies: air samplers, ww, and yes: direct samples from people, too (saliva, nasal swabs) & even animals #OneHealth. 2/
Importantly, however, I cannot stress enough the need to look beyond the pure technology driven solutions. It’s not just genome sequencing machines, library prep, read QC, 🧬 consensus assembly & phylogenetics. Community engagement & “buy-in” from general public is PIVOTAL. 3/
Scientists & public health workers, please please collaborate w/ sociologists. Engage w/ folks in your communities. We must not wait for cases to show up in hospitals to identify a new microbial / viral threat is on the loose. 4/
We need #EquitableGenomicSurveillance solutions. If we fail to address Equity —full circle, 360°—we won’t be ready for the next pandemic. Nor will we be able to fully benefit from powerful new models for infection control that new 🧬 sequencing tech can offer us 🙏 5/(end)
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“Mr. Moreau caught the coronavirus during its second wave in 2020 & suffered a stroke while working at his desk. A friend of his died just last weekend. But vaccination has plateaued at 39%, ~24 percentage points lower than the U.S. over all” #VaccinesWorktheglobeandmail.com/world/us-polit…
“It is places such as East Feliciana that are increasingly suffering the consequences. The parish has seen 154 deaths in a population of 19,500, a per-capita rate more than double those of Los Angeles & Chicago, and triple that of New Orleans.”
“Out of the 100 U.S. counties with the highest death rates, 95 have populations of fewer than 100,000 people. None contain major cities.”
Sadly— as highly important as such work is, I’m concerned about the inevitable sound bytes & memetic take away tweets & headlines about how “mild COVID will give you brain damage”... /2
..& on the other side, COVID-contrarians will point to these apocalyptic takes & say: “My kid recovered from COVID 4 months ago and his latest report card is straight A’s. We need to quit it with vaccines & masking” /3
Not only does @23andMe sell customer🧬+ health data behind our backs, but they don't genotype a key #COVID19 susceptibility locus, OAS1 rs10774671. @NebulaGenomics better wrt PRIVACY & QUALITY. Less astrology-like popsci takes, more data🧵
OAS1 COVID ref ⛓️elifesciences.org/articles/71047
Here's the Science (AAAS) / UK study showing functional relevance that got much more media attention than the eLife paper that was published slightly earlier.. comparing when each preprint went live (April 22, 2021 eLife vs. May 9, 2021 Science/AAAS) science.org/doi/10.1126/sc…
Vivek's piece in the WSJ argues that policy makers must tolerate the spread of "milder" variants like #Omicron. @angie_rasmussen & others rightfully criticized this Very Bad Idea. There are many things wrong with Vivek's arguments. 🧵 1/n
Firstly, he is just gloriously wrong on the facts. Yes, variants can emerge in the U.S., there are immune compromised (IC) people here & #Omicron and other variants can and do find their way to replicate in IC hosts in USA. (There's also endemic SARS-CoV-2 in Deer). 2/
Vivek says U.S. "enjoys widespread vaccination" so variants won't emerge / evolve while we let Omicron "rip".. Widespread vaccination: Maybe.. But U.S. vaccine uptake is PATCHY.. Does this look like great vaccination rates? 👇usnews.com/news/best-stat… 3/
💥 Very important finding: Airborne infectivity of SARS2 🦠 decreases by ~90% within 20 min. The group hasn’t yet tested #Omicron —but overall, this work underscores that crowding indoors drives the pandemic. 🧵 #COVIDisAirborne cc: @EricTopolmedrxiv.org/content/10.110…
“We report changes in the infectivity of the airborne virus over timescales spanning from 5 s to 20 minutes and demonstrate the role of two microphysical processes in this infectivity loss: particle crystallisation and aerosol droplet pH change.”
“A decrease in infectivity to ~10 % of the starting value was observable for SARS-CoV-2 over 20 mi, w/ a large proportion of the loss occurring within the first 5 min after aerosolisation.”