Thread by @vipintukur

The possibility of using animal-adapted variants to develop a multivalent SARS-CoV-2 vaccine, such as that for the vaccinia virus for smallpox.

medrxiv.org/content/10.110…

In fact, a half-adapted mink variant was barely able to spread among humans. It probably had low virulence and was quickly replaced by a more infectious variant.

A more adapted variant would probably not be able to spread from humans to humans. Once a weakly toxic variant is selected, it can be maintained and propagated in its host and cultured cells.

The efficacy can be expected from the fact that SARS2 does not mutate, particularly small ORFs. Perhaps the virus does not have sufficient flexibility. However, in the body, all proteins are presented as antigens.