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Feb 6 • 5 tweets • 2 min read
1/ Reminder: I realize it’s the single hardest concept to get across, but for all these years I have and continue to suggest there’s a crucial case of lipoprotein profiles as often more a reflection of disease than the independent drivers of it. (ie — from 2018 re general👇)
2/ For example, I certainly know so much more on the workings of #LEM* than when I tweeted this from 2018, but does the foundation still hold up… do I think this is more relevant or less? Definitely more!

(*Obligatory mention of @nicknorwitz here and others re coming paper!)
3/ The bottom line is that while the independent causal role of lipoproteins (whether LDLp, sdLDL, oxLDL, glLDL, etc) are well worth examining. We should likewise investigate how *both* lipid profiles and CVD can be downstream of poor lipid metabolism.
4/ Again, if a combination of these markers as profiles tell us more about outcomes than looking to them in isolation, we should consider putting more of our energy there. That’s how we came to recognize “Metabolic Syndrome” originally (which, ofc, includes ⬇️HDL&⬆️TG)
Yes — likewise 👇

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More from @realDaveFeldman

Dave Feldman Profile picture
Feb 1
1/ Hi guys! Just dropped a new interview with Bill Cromwell (@Lipoprotein) on Youtube regarding their Precision Health Report platform.

I really love their model and suggest you check it out...

(precisionhealthreports.com/oyl)

2/ They've kindly agreed to provide a coupon code "CITIZEN" for their package to help get both a discount and allow opting in your anonymized data to our OYL anonymous data pool. (Just like we do at our site)

No, there's no $$$ or compensation for us or anything like that...
3/ ... Which might seem confusing since they are technically a competitor given they offer bloodwork as well.

But hello -- @siobhan_huggins and I are *always* game for *everyone* finding what works for them. And seriously, I think this platform is a strong step forward.
Read 5 tweets
Dave Feldman Profile picture
Feb 1
I'm incredibly honored at @nicknorwitz's offer for a transplant -- so blessed to have such a good friend they'd donate their own...

- eyebrows! 😂

Okay, but seriously, let's talk about disappearing eyebrows and how it can potentially signal reasons of concern...
2/ Occasionally I get a doctor (often a Dermatologist) ask if I've checked for hypothyroidism given it can be associated with loss of the outer eyebrow.

However, this is usually resolved when they see my eyebrows up close given it doesn't follow the same pattern... Image
3/ Often there is a pronounced pinching or abrupt halt in the pattern of spread. But to be sure, this is more of what I hear from them. I haven't researched much on it given I already knew this pattern was common in my family-- but this study was helpful👇 ncbi.nlm.nih.gov/pmc/articles/P…
Read 6 tweets
Dave Feldman Profile picture
Jan 29
1/ A very busy time

But in this late moment of calm before the weekend, I'm finding myself truly humbled that our #LMHRpaper is finalized and has crossing so many interested eyes.

I hope many will agree with us this phenomenon is well worth researching.

cholesterolcode.com/our-paper-on-l…
2/ Via @nicknorwitz: "... this paper has stimulated vigorous discussion, risen to the top of its journal for all time reads, and is among the top 15 trending papers across all American Society of Nutrition associated journals for the year 2021." nutrition.org/15-trending-nu…
3/ There's quite a bit more work in the pipeline from the many great collaborators I have the honor to be working with. We're passionately working on a #LipidEnergyModel paper, the #LMHRstudy (currently underway), and a couple other projects I can't announce just yet...
Read 5 tweets
Dave Feldman Profile picture
Jan 23
1/4 Three #polls

I’m going to do a brief video soon on messaging.

But first I want to get a few polls* on what those following my account feel themselves 👇

(*yes, I know there’s a margin for trolling, as always. 😂)
2/4 When I’ve said I’m “cautiously optimistic” regarding context of metabolic fat-adaptation, you take that as…

1) I’m very confident LDL is of no concern.

2) I don’t know if LDL is of concern in this context, it very well could be. But I current lean toward the optimistic.
3/4 True or false-

I think you should listen/read only resources coming from those skeptical that LDL causes heart disease.
Read 4 tweets
Dave Feldman Profile picture
Jan 19
1/ One of the toughest skills to master is avoiding sarcasm save those moments where you're pretty sure it will be well received by almost everyone.

Occasionally, I do a self check to see how that's going. Gotta say, I'm pretty pleased with some of the most recent ones...
2/ Everyone can related to the "I'm doing Diet X..." challenge. This one from May...

3/ This one is my trolling the trolling. 😂

Read 10 tweets
Dave Feldman Profile picture
Dec 23, 2021
1/ #ReminderThread -

One thing that still surprises me is when I'm tweeting or retweeting opinion, articles, etc that are generally pro #LDL #Cholesterol-lowering or LDL-as-problematic (such as recently) I get some pushback...
2/ If you've followed me a long time, you should know this is something I'm proactive about doing -- in fact, I'm more active at doing it now than ever.

If you've only heard the ⬆️LDL isn't-so-bad case, please hear out the mainstream case on how ⬆️LDL *is* bad...
#NoEchoChambers
3/ If you somehow hadn't already heard, I literally spearheaded a crowdfunding campaign for an IRB-approved study with longitudinal CCTAs to track plaque development

Why? Because we don't know what the risk levels are for this context. If we did, there'd be no need for the study
Read 11 tweets

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