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Jan 29 • 5 tweets • 4 min read
1/ A very busy time

But in this late moment of calm before the weekend, I'm finding myself truly humbled that our #LMHRpaper is finalized and has crossing so many interested eyes.

I hope many will agree with us this phenomenon is well worth researching.

cholesterolcode.com/our-paper-on-l…
2/ Via @nicknorwitz: "... this paper has stimulated vigorous discussion, risen to the top of its journal for all time reads, and is among the top 15 trending papers across all American Society of Nutrition associated journals for the year 2021." nutrition.org/15-trending-nu…
3/ There's quite a bit more work in the pipeline from the many great collaborators I have the honor to be working with. We're passionately working on a #LipidEnergyModel paper, the #LMHRstudy (currently underway), and a couple other projects I can't announce just yet...
4/ But if I could have just one brief moment to thank all the fellow #CitizenScientists – every one of you there back in 2017 when I was first writing about the #LMHR phenotype and contributing your data and thoughts.

This research wouldn't be possible without your help. 🙏
5/ And lastly, I have so much thanks for every single person who has contributed / is still contributing to our public charity at the CitizenScienceFoundation.org to support further study on the #LMHRs, particularly with regard to high #LDL and its association with risk.

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More from @realDaveFeldman

Dave Feldman Profile picture
Jan 23
1/4 Three #polls

I’m going to do a brief video soon on messaging.

But first I want to get a few polls* on what those following my account feel themselves 👇

(*yes, I know there’s a margin for trolling, as always. 😂)
2/4 When I’ve said I’m “cautiously optimistic” regarding context of metabolic fat-adaptation, you take that as…

1) I’m very confident LDL is of no concern.

2) I don’t know if LDL is of concern in this context, it very well could be. But I current lean toward the optimistic.
3/4 True or false-

I think you should listen/read only resources coming from those skeptical that LDL causes heart disease.
Read 4 tweets
Dave Feldman Profile picture
Jan 19
1/ One of the toughest skills to master is avoiding sarcasm save those moments where you're pretty sure it will be well received by almost everyone.

Occasionally, I do a self check to see how that's going. Gotta say, I'm pretty pleased with some of the most recent ones...
2/ Everyone can related to the "I'm doing Diet X..." challenge. This one from May...

3/ This one is my trolling the trolling. 😂

Read 10 tweets
Dave Feldman Profile picture
Dec 23, 2021
1/ #ReminderThread -

One thing that still surprises me is when I'm tweeting or retweeting opinion, articles, etc that are generally pro #LDL #Cholesterol-lowering or LDL-as-problematic (such as recently) I get some pushback...
2/ If you've followed me a long time, you should know this is something I'm proactive about doing -- in fact, I'm more active at doing it now than ever.

If you've only heard the ⬆️LDL isn't-so-bad case, please hear out the mainstream case on how ⬆️LDL *is* bad...
#NoEchoChambers
3/ If you somehow hadn't already heard, I literally spearheaded a crowdfunding campaign for an IRB-approved study with longitudinal CCTAs to track plaque development

Why? Because we don't know what the risk levels are for this context. If we did, there'd be no need for the study
Read 11 tweets
Dave Feldman Profile picture
Dec 22, 2021
1/ Yes, will comment on it in time as I have some follow up questions and comments -- but for the moment, I want to reemphasize how much I appreciate @deirdre_tobias publishing the baseline charts, making the code available, and overall devoting her time to this project...
2/ Seeing this progress and unfold over a matter of weeks is fantastic. I'm used to either getting a "sneak preview" of what an analysis might show with a given dataset or be told it will require full publication (many months and dollars down the road) in order to be public...
3/ In other words, I wish we could get this kind of turnaround and transparency on every major dataset. @deirdre_tobias has effectively done something I've been asking after for years -- and she did so at no cost.

That's worth its own distinction and one I certainly laud.
Read 4 tweets
Dave Feldman Profile picture
Dec 17, 2021
1/ Yes -- if you're curious as to why @nicknorwitz and I are chatting so often about ANGPTLs, it's worth working our way backwards...

If you're powered by fat, your tissues are getting it from free fatty acids or triglycerides (which is really three FAs bundled together)...
2/ Recently I was much more focused on fasting (see ) and lipoprotein lipase (LPL) dynamics (see ) Image
3/ And indeed, the regulatory strings behind LPL up and down regulation is a much bigger part of the story with regard to VLDL turnover -- and thus potential resulting effects on LDL-C, HDL-C, and Triglycerides (TG).
Read 5 tweets
Dave Feldman Profile picture
Dec 13, 2021
1/ If you want to hear a great discussion on the #LMHRstudy from my colleague,@DrNadolsky (who is most definitely pro-#LDL #Cholesterol lowering), I highly recommend this podcast that just dropped via @Plant_proof.

I'll add just a few quick thoughts...
2/ Firstly, this may be the most I've heard myself talked about in a podcast I wasn't in (😂 weird, but understandable given the context).

But while certainly critical in many respects, I felt both @DrNadolsky and @Plant_proof provided a lot of good context...
3/ @DrNadolsky bring up my oft-repeated phrase, "cautiously optimistic" [in the context of higher LDL/ApoB as a seemingly resulting from metabolic fat-adaption]

Worth repeating that mine is a hypothesis and should be treated as such, hence the "cautious" part of the phrase...
Read 8 tweets

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