1/4 Three #polls

I’m going to do a brief video soon on messaging.

But first I want to get a few polls* on what those following my account feel themselves 👇

(*yes, I know there’s a margin for trolling, as always. 😂)
2/4 When I’ve said I’m “cautiously optimistic” regarding context of metabolic fat-adaptation, you take that as…

1) I’m very confident LDL is of no concern.

2) I don’t know if LDL is of concern in this context, it very well could be. But I current lean toward the optimistic.
3/4 True or false-

I think you should listen/read only resources coming from those skeptical that LDL causes heart disease.
4/4 True or false-

You, personally (be honest), have heard me express one or more of the following:

(A) Work with your doctor

(B) Consider the pro-LDL lowering case

(C) We don’t yet know if the LMHR phenotype is safe- we need stronger data

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Dave Feldman

Dave Feldman Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @realDaveFeldman

Jan 19
1/ One of the toughest skills to master is avoiding sarcasm save those moments where you're pretty sure it will be well received by almost everyone.

Occasionally, I do a self check to see how that's going. Gotta say, I'm pretty pleased with some of the most recent ones...
2/ Everyone can related to the "I'm doing Diet X..." challenge. This one from May...

3/ This one is my trolling the trolling. 😂

Read 10 tweets
Dec 23, 2021
1/ #ReminderThread -

One thing that still surprises me is when I'm tweeting or retweeting opinion, articles, etc that are generally pro #LDL #Cholesterol-lowering or LDL-as-problematic (such as recently) I get some pushback...
2/ If you've followed me a long time, you should know this is something I'm proactive about doing -- in fact, I'm more active at doing it now than ever.

If you've only heard the ⬆️LDL isn't-so-bad case, please hear out the mainstream case on how ⬆️LDL *is* bad...
#NoEchoChambers
3/ If you somehow hadn't already heard, I literally spearheaded a crowdfunding campaign for an IRB-approved study with longitudinal CCTAs to track plaque development

Why? Because we don't know what the risk levels are for this context. If we did, there'd be no need for the study
Read 11 tweets
Dec 22, 2021
1/ Yes, will comment on it in time as I have some follow up questions and comments -- but for the moment, I want to reemphasize how much I appreciate @deirdre_tobias publishing the baseline charts, making the code available, and overall devoting her time to this project...
2/ Seeing this progress and unfold over a matter of weeks is fantastic. I'm used to either getting a "sneak preview" of what an analysis might show with a given dataset or be told it will require full publication (many months and dollars down the road) in order to be public...
3/ In other words, I wish we could get this kind of turnaround and transparency on every major dataset. @deirdre_tobias has effectively done something I've been asking after for years -- and she did so at no cost.

That's worth its own distinction and one I certainly laud.
Read 4 tweets
Dec 17, 2021
1/ Yes -- if you're curious as to why @nicknorwitz and I are chatting so often about ANGPTLs, it's worth working our way backwards...

If you're powered by fat, your tissues are getting it from free fatty acids or triglycerides (which is really three FAs bundled together)...
2/ Recently I was much more focused on fasting (see ) and lipoprotein lipase (LPL) dynamics (see ) Image
3/ And indeed, the regulatory strings behind LPL up and down regulation is a much bigger part of the story with regard to VLDL turnover -- and thus potential resulting effects on LDL-C, HDL-C, and Triglycerides (TG).
Read 5 tweets
Dec 13, 2021
1/ If you want to hear a great discussion on the #LMHRstudy from my colleague,@DrNadolsky (who is most definitely pro-#LDL #Cholesterol lowering), I highly recommend this podcast that just dropped via @Plant_proof.

I'll add just a few quick thoughts...
2/ Firstly, this may be the most I've heard myself talked about in a podcast I wasn't in (😂 weird, but understandable given the context).

But while certainly critical in many respects, I felt both @DrNadolsky and @Plant_proof provided a lot of good context...
3/ @DrNadolsky bring up my oft-repeated phrase, "cautiously optimistic" [in the context of higher LDL/ApoB as a seemingly resulting from metabolic fat-adaption]

Worth repeating that mine is a hypothesis and should be treated as such, hence the "cautious" part of the phrase...
Read 8 tweets
Nov 24, 2021
1/ One of the biggest challenges in discussing these tough topics is that it can sometimes have a greater polarization effect on those listening.

I want to reiterate (as I have many times) that I strongly appreciate @ethanjweiss and our many great conversations public & private
2/ Our last conversation on @chadinabhan’s podcast certainly stirred a lot of emotion, and in that sense, it was unusual given our typical rapport.

But regardless, I have and continue to hope we can move forward with a mutual interest toward cordial conversation.
3/ As a rule, I generally avoid criticizing behavior of others given it creates a standard of perpetual policing.

That said, I’d like to ask a personal favor. I’d love if there were less personal attacks on all sides— particularly to @ethanjweiss
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(