@UofRegina wastewater analysis shows rebounding viral load levels week-over-week, suggestive of ongoing high rates of viral transmission in community.
BA.1 remains dominant but 18% BA.2 reported too. We expect BA.2 to dominate in coming days. /2
Also, note that @UofRegina plot is time-lagged by 13 days, as the most recent analysis comes from the time period b/w Feb 6-12 inclusive.
So presumably proportion of BA.2 in Regina is higher now, just don't know how much higher. /3
Not much better in Saskatoon. @usask_water analysis for week ending Feb 16 shows 98.1% INCREASE in viral load burden compared to week prior.
No breakdown of proportion of BA.1 vs BA.2 included that I could find. "All Omicron". /4
Levels of wastewater viral load in Saskatoon are now the HIGHEST they have ever been throughout the course of the pandemic.
In summary, NO clear signal that Omicron has peaked in either Saskatoon or Regina.
I am guessing that BA.2 is driving more transmission, but not sure. /5
Things are different in 'rural' Saskatchewan. Prince Albert shows week-over-week DECREASE of nearly 64%. That's good.
However, rural #SK has lagged the major cities w/ Omicron, so guessing that BA.2 hasn't quite 'arrived' in smaller Saskatchewan cities quite yet. /6
You can see the significant decrease in viral load burden in Prince Albert week over week. We'll see whether BA.2 plays a potential role in increasing viral load burdens in the coming days. /7
However, what's unclear is that only 77% of viral load burden is being driven by Omicron. Delta is now "undetectable".
What's the remaining 23%? Is this potentially BA.2?
Would depend on the gene targets used for sequencing, but would be helpful to get clarification. /8
North Battleford's week-over-week virall load burden is also increasing, up nearly 40%. This represents the highest viral load burden North Battleford has ever seen, and ~86% is Omicron. Delta undetectable. Is remaining 14% BA.2? /9
Summary:
- Omicron continues to surge across ALL of Saskatchewan
- Removal of protections (e.g. indoor masking) will prolong Omicron wave in Saskatchewan
- BA.2 will dominate in #SK 'soon'
- With no publicly available data, impossible to know where we're at
"Hi Alex, what's BA.2? Is it a little bad or is it REALLY bad?"
BA.2 is a sub-lineage of Omicron. The 'original' lineage of Omicron is designated as BA.1 & remains the dominant strain circulating in most parts of Canada currently.
A brief 🧵 of what we know thus far. /1
BA.1 & BA.2 are both classified by @WHO as Omicron, but are distinct viruses. See the phylogenetic diagram below (thx @kallmemeg).
BA.2 has over 25 mutations that differentiate it vs BA.1.
Many questions still exist around how similar BA.1 & BA.2 are clinically. /2
Danish pre-print data comparing transmission of BA.1 vs BA.2 in household settings suggests BA.2 IS more transmissible than BA.1.
BA.2 also LIKELY possess more immune-evasive properties vs BA.1 that could reduce vaccine efficacy. /3
Great @SaskHealth Town Hall last PM re: #COVID19 in Saskatchewan. Key points:
- Community MAY have peaked w/ Omicron.
- Non-ICU/ICU numbers STILL rising
- #SK non-ICU system capacity MAXED OUT.
- Relaxed public health measures in #SK = LONGER & MORE SEVERE Omicron wave
Yesterday, Premier Moe said #COVID19 cases in Saskatchewan are more frequent in the vaccinated vs. those who aren't.
THUS, vaccines DON'T prevent infection with or transmission of Omicron.
The Premier's conclusions are INCORRECT. But why?
It's complicated. Here we go.
🧵 /1
The Premier's incorrect conclusion stems from a simplistic interpretation of the data. 'Base rate fallacy' is one problem, but there are MANY other factors at play.
We explained 'base rate fallacy' with cases & vax status back in August. See below. /2
For 'base rate fallacy' & #COVID19 & hospitalizations, this is the diagram EVERYONE uses (thx @MarcRummy).
MANY more people are fully vaccinated now, so even though a small proportion of them go to hospital, the absolute numbers are the same as those unvaccinated. See below. /3
On January 18, @PremierScottMoe posted a graphic comparing "real-time" QC / ON / MB hospitalizations / ICU admissions vs. SK.
Problem: SK is ~3 weeks behind those provinces w/ our Omicron surge.
We MUST be careful interpreting this data. We're NOT OK, Saskatchewan.
🧵👇 (1/n)
A more reasonable and appropriate comparison would be to look at where MB/QC/ON were at ~3 weeks from Jan 18 to create a more fair "apples vs apples" graphic.
For those 3 provinces, that would take us to about Dec 28. Let's see what the data shows us. (2/n)
We have #QC data from Dec 28 & Jan 18 in the graphics below courtesy @sante_qc:
Dec 28: 804 in hospital (including ICU), 128 in ICU
Jan 18: 3425 in hospital (including ICU), 285 in ICU