"The effectiveness of 3 doses vs. hospital admission due to #Delta... fall from 89% <3 months to 71% from 3 months+...
After 3 doses, VE of BNT162b2 against hospital admission due to the #Omicron variant was 85% at <3 months but fell to 55% at 3 months+."
thelancet.com/journals/lanre…
After 3 doses, VE of BNT162b2 against hospital admission due to the #Omicron variant was 85% at <3 months but fell to 55% at 3 months+."
thelancet.com/journals/lanre…
I'm very interested in the virologists' explanation of why would VE vs. hospitalization wane this much over time if, for severity, T-cells are exclusively more important than antibodies. It seems to me real-life data doesn't support currently presumed dogma. Novelty=severity, no? 
"Our study is one of the 1st to report long-term follow-up outcomes after receipt of a booster dose, stratified by age. Similar to a recent CDC report showing waning effectiveness of mRNA #COVID19 vaccines after a 3rd dose, we also detected early SIGNS of WANING against SEVERE...
outcomes caused by the #Omicron variant from 3 months onwards after the receipt of a booster dose..."
Here's the authors' conclusion:
"Previous reports have indicated that T-cell immunity might have a role in the prevention of severe #SARSCoV2 infection & laboratory results...
Here's the authors' conclusion:
"Previous reports have indicated that T-cell immunity might have a role in the prevention of severe #SARSCoV2 infection & laboratory results...
have suggested that T-cell epitopes have remained mostly UNALTERED for #Omicron. The relationship between cell-mediated immunity & protection against severe infection, however, NEEDS MORE RESEARCH...
In the future, additional doses of current, adapted, or novel #COVID vaccines...
In the future, additional doses of current, adapted, or novel #COVID vaccines...
might be needed to MAINTAIN high PROTECTION against SEVERE infection and sufficient vaccine pressure on future waves of #SARS2 infection."
Well, duh!
But, how else to justify constant mass reinfections without the fairytale that once exposed you're protected from severe for life?
Well, duh!
But, how else to justify constant mass reinfections without the fairytale that once exposed you're protected from severe for life?
People neglect that VE vs. hospitalization is in fact a MULTIPLICATION of relative risk reduction vs. infection AND relative risk reduction vs. hospitalization post-infection.
(Protective results are likely similar post "natural" infection, though after unnecessary suffering.)
(Protective results are likely similar post "natural" infection, though after unnecessary suffering.)
If there's no protection vs. infection, like vs. #Omicron after some time post-immunization, then what's left is only protection vs. hospitalization post-infection. Looking at Israel's current data on their dashboard, there's almost no relative protection vs. infection at all.
That's what I searched for last year by analyzing Israel's real-life data, which showed a 1:3 risk reduction vs. hospitalization post-infection in vaccinated (primed) vs. unvaccinated (naïve). I wanted to see WHAT'S LEFT OF PROTECTION once we get infected.
https://twitter.com/x2IndSpeculator/status/1457684272240906241?s=20&t=81NdT-_y-TLWftGpa7yUJA
My point is... when they say novelty = severity, it implies 100%. Real-life data shows more like 1:3 risk reduction post-infection, or total VE vs. hospitalization of approximately 66% once protection vs. infection is near zero (like now post 3-6m.).
Great, but 66% is not 100%.
Great, but 66% is not 100%.
Why the surprise? This is known since Delta; I've shown charts of waning both vs. infection & severe last August.
"Trends in waning vs. #SARSCoV2 outcomes due to Delta were generally similar, but with higher effectiveness estimates at each timepoint than those seen for Omicron."
"Trends in waning vs. #SARSCoV2 outcomes due to Delta were generally similar, but with higher effectiveness estimates at each timepoint than those seen for Omicron."
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