1/9-"Despite strong levels of vaccination among older pple, #COVID19 killed them at higher rates during this winter’s #Omicron wave than it did last year, preying on long delays since their last shots and the variant’s ability to skirt immune defenses." nytimes.com/2022/05/31/hea…
2/9 - "This winter’s wave of deaths in older people belied the #Omicron variant’s relative mildness. Almost as many Americans 65+ died in 4 months of the Omicron surge as did in 6 months of the #Delta wave,even though the Delta variant,tended to cause more severe illness/person."
3/9 - "This is not simply a pandemic of the unvaccinated,” said Andrew Stokes, from Boston University who studies age patterns of #COVID19 deaths. “There’s still exceptionally high risk among older adults, even those with primary vaccine series.” jamanetwork.com/journals/jaman…
4/9 - "I think we are going to see the death rates rising,” said Dr. Sharon Inouye, a geriatrician and a professor of medicine at Harvard Medical School. “It is going to become more and more risky for older adults as their immunity wanes." medrxiv.org/content/10.110…
5/9 - "I don’t think we should treat the premature death of older adults as a means of ending the pandemic,” Dr. Stokes said. “There are still plenty of susceptible older adults, living with comorbid conditions or living in multigenerational households,who are highly vulnerable.”
6/9 - "Sara Tartof, the study’s lead author and an epidemiologist at Kaiser Permanente in Southern California, said that roughly 9 percent of people 65 and older in the study were immunocompromised, compared with 2.5 percent of adults under 50." thelancet.com/journals/lanre…
7/9 - "Excess deaths were more heavily concentrated in people 65+ during the #Omicron wave than the #Delta surge. Overall, there were more excess deaths in Massachusetts during the first 8 wks of Omicron than during the 23-wk period when Delta dominated." jamanetwork.com/journals/jama/…
8/9 - "A drop-off in Covid precautions this winter, combined with the high transmissibility of #Omicron, left older people more exposed. While older people had once been wearing masks at rates higher than those of younger people, that gap had effectively disappeared by mid-2021."
9/9 - "Antiviral pills are now being administered in greater numbers, but it is difficult to know who is benefiting from them. Scientists said that the wintertime spike in #COVID19 death rates among older Americans demanded a more urgent policy response."
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1/9 - "The WHO Technical Advisory Group on Virus Evolution [is] developing a global risk-monitoring framework for #SARSCoV2 variants, based on a multidisciplinary approach that includes in silico, virological, clinical and epidemiological data." nature.com/articles/s4159…
2/9 - "[This group, namely TAG-VE] uses a Delphi consensus method to establish which emerging variants are considered variants of interest (VOIs) or variants of concern (VOCs) As of 26 March 2022, 8 VOIs and 5 VOCs had been designated."
3/9 - "The first available data on emerging variants that are assessed by TAG-VE are viral sequences and their associated metadata shared on publicly accessible genetic sequence databases (e.g., GISAID, Genbank, the European Nucleotide Archive, and the DNA Database of Japan)."
1/7 - "The evolutionary rate of the related variola virus has been estimated to be about about 1-2 nucleotide changes per year for a nearly 200,000 nucleotide genome. This makes 47 substitutions in the space of 3-4 years an unexpectedly large number." virological.org/t/initial-obse…
2/7 - As #MonkeypoxVirus is considered a zoonotic virus with limited human to human transmission, this long branch may be evidence of adaptation to humans allowing for the sustained transmission that is now observed."
3/7 - "However, 42 out of 47 of these nucleotide changes are of a particular type, a dinucleotide change from TC→TT or its reverse complement GA→AA. This specific mutation is characteristic of the action of the APOBEC3 family of deaminases."
1/6 - #VarioleDuSinge: 316 cas confirmés, toujours pas de décès:
N’en fait-on pas un peu trop?
A-t-on perdu la raison avec la pandémie de #COVID19?
Ne voit-on pas des pandémies partout désormais?
Je vais tenter d’expliquer pourquoi je pense que la réponse est 3 fois négative.
2/6 - Il est possible que la #VarioleDuSinge soit aussi bénigne que la varicelle.
Mais on ne sait pas encore.
Si on déplore 20 décès par varicelle pour 700’000 cas/an en France, aujourd’hui on ne sait pas si on ne va pas dénombrer 1 ou 2 décès/1000 infections par #MonkeypoxVirus.
3/6 - A priori, la #VarioleDuSinge est peu transmissible, moins que la varicelle ou le #COVID19, mais on ignore encore si le #MonkeypoxVirus s’est adapté, par la génétique (par mutations) ou l’épigénétique (grâce à son équipement enzymatique).
1/9 - “The Angel of Death was an oddly serene term for a disease that killed millions and left survivors disfigured by “small pocks”, or blisters on the skin. Smallpox, named to distinguish it from the “great pox” of syphilis, was eradicated in 1980.” ft.com/content/2067e6…
2/9 - “Now a smallpox vaccine is being wheeled out again to combat an unusual outbreak of #monkeypox, a milder disease caused by a related virus. As of May 22, the WHO has recorded > 250 cases in the biggest outbreak seen outside west and central Africa, where it is endemic.”
3/9 - “The smallpox vaccine, marketed as Imvanex, is also licensed for #monkeypox and provides a good degree of cross-protection. The UKHSA, which has 5,000 doses and more on order, stated it was immunising close contacts of confirmed cases and advising 21-day quarantines.”
1/5 - "[Le virus de la #VarioleDuSinge a un] double brin d'ADN, lourd de 200.000 bases (à titre de comparaison, le SARS-CoV-2, qui est un virus à ARN, en a 30.000): c'est donc un virus doté d'un gros équipement qui le rend assez plastique et stable." slate.fr/story/228421/v…
2/5 - "On ne connaît à ce jour que deux variants du monkeypox: la souche appelée centre-africaine, isolée initialement en République démocratique du Congo, et la souche ouest-africaine, isolée au Nigeria. C'est d'ailleurs cette dernière que l'on retrouve dans l'épisode actuel."
3/5 - "Les taxonomistes ne sont décidément pas très doués pour nommer les virus. Pas plus que la varicelle (en anglais «chickenpox») n'est une variole du poulet, le monkeypox n'est une variole du singe!"
1/9 - “#Monkeypox appears to have exploded out of nowhere in the past two weeks, spreading across Europe, the Americas, and other regions. But warning signs appear to have gone unheeded.”
(Source: @HelenBranswell). statnews.com/2022/05/26/war…
2/9 - “An unusual and long-running outbreak in Nigeria should have served as notice that it was only a matter of time before this orthopoxvirus pushed its way to the center of the infectious diseases stage, experts say.”
3/9 - “After decades without cases, Nigeria experienced a large #monkeypox outbreak starting in 2017 that continues to this day. Prior to this year, that outbreak spread beyond Nigeria’s borders eight times, with infected people traveling to the US, the UK, Israel and Singapore.”