📌How to design a brain 101🧠🏗️

A 🧵 on how I use @powerpoint to create illustrations

🎨Key tools and my 2 secret weapons:

-@gboulouis adding "advanced" stuff
-@MVarkanitsa reviewing every little detail

#MedTwitter #MedEd #NeuroTwitter #NeuroRad #Neurology #neuropath #FOAMed
This 🧵 is inspired by a great recent post from @teachplaygrub, since we are using similar methods and tools on #PowerPoint!

🛠️ The Basic Toolkit:
-curve function ➰
-edit points function✴️
-Layering 🃏
-Zooming (x300-400%) for details 🔍

🎨 colors, shadows, 3D effects etc., depends on individual's style

1/
♾ It's important think the"reverse engineering" of these illustrations, to better realize that they are:
-multicomponent
-multilayered

➡️See for example the brain schematic on Cerebral Amyloid Angiopathy brain features: made of many individual shapes, figures and layers...

2/
To break this down, let's see how to design only a part of the brain 🧠: a piece of the cortex and some small vessels

#MedStudentTwitter #MedEd #FOAMed #tweetorial #FOAMrad #Neurology #Neurosurgery #RadEd #illustration #PowerPoint

3/
👉🏿This illustration is in fact comprised of 4 individual elements (some are groups) that are created separately, but with the final piece in mind.

(I usually sketch🖌️ on paper w pencils the basic drawing that I aim to create, to get the general idea)

4/
Step 1: Curve tool - gives enormous control for drawing the basic shapes you need

➰Now, I have created the basic shape for the cortex 👇🏿

I will do a similar, but smaller shape for the white matter...

5/
Step 2: add color🎨("Shape fill" tool) and outline
(you can do fancy things like gradient fills, shadows, 3D, but let's go with a simple fill)

Step 3: layering🃏- you overlay shapes to create the whole

Now a basic piece of cortex and some white matter is taking shape..👇🏿

6/
Step 4: Correction of details with the "Edit points" tool under magnification

**each shape is comprised of individual connected points, you just don't normally see them!

I use this to make small alterations to shapes: change curvature of points, angle, add/delete points...

7/
Step 5: To create the blood vessel, I use again the Curve tool under magnification to make the outline of the shape, in this case a penetrating arteriole.

... add color, outline, edit points PRN

See for example a smaller arteriole in the making👇🏿
(you can sprinkle VEGF)

8/
As you would imagine, the more elaborate a shape is, the more painstaking the process of modifying the points is...

9/
In some illustrations or parts of them, if I aim for #Anatomy #neuropath #NeuroRad #biological accuracy, I might consult an atlas or an actual photo.

This is what I used for example to design the #cortical layers 👇🏿

10/
⚫️ Now, just for fun, let's add some @microbleeds in the cortex.

I draw a circe, paint it black, add a bit of black glow to represent the blooming effect on blood-sensitive MRI, make copies, and add them to the illustration 👇🏿

11/
🧠🏗️ And this is how you build a brain, piece (of cortex) by piece...

I use more or less the same method for more complicated illustrations.

I hope you find this helpful!

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More from @a_charidimou

Jun 15
🚨Early management of Intracerebral Hemorrhage🩸🧠

📒 My cheat-sheet
(focus on approaches to limit hematoma expansion)

#MedTwitter #neurotwitter #NeuroTwitter #NeuroRad #Neurology #Neurosurgery #stroke #MedStudentTwitter @gboulouis @marco_pasi85 @NMatch2023 #FOAMncc
⚡️For anticoagulation reversal in ICH, see this high yield and simple algorithm from @American_Heart updated ICH 2022 guidelines🩸🧠 @StrokeAHA_ASA
For a quick summary of the @American_Heart updated ICH 2022 guidelines 🩸🧠, the recent 🧵 that @MicieliA_MD put together is amazing

Read 5 tweets
Jun 14
💥Dramatic Intracerebral Hemorrhage🩸🧠 expansion.

Hyperacutely➡️again showing that the window for intervention in ICH is pretty narrow!

⏰=💥🩸🧠

🙏🏿@VancouverStroke for reminding me of these cases!

#neurotwitter #NeuroTwitter #NeuroRad #Neurology #Neurosurgery #stroke
Here is the case of ongoing bleeding @VancouverStroke mentioned yesterday. @TheLancet @TheLancetNeuro

thelancet.com/journals/lance…
Read 4 tweets
Jun 13
The🟡 Spot Sign might be dead🧟🧟‍♂️ for ICH🧠🩸!

(At least as practice-changing marker for Intracerebral Hemorrhage expansion)

🍄ICH shape/density markers on plain NCCT are more promising👇🏿👇🏿

#neurotwitter #FOAMrad #radres #NeuroTwitter #NeuroRad #Neurology #Neurosurgery #stroke Image
NCCT markers of hematoma expansion picture from: pubmed.ncbi.nlm.nih.gov/31364773/

These markers still need harmonization and improvement of diagnostic accuracy..
pubmed.ncbi.nlm.nih.gov/34842473/ Image
Read 6 tweets
May 18
re: ICH Prevention in People w ⬆️Risk MRI findings in @American_Heart updated 2022 ICH guidelines🧠🩸

📌 Refers to incidentally found MRI markers of small vessel disease (SVD) - a common question

Prompted by @interneurona unpacking below (short 🪀)
For context:
🚫MRI is not routinely done for risk stratification of first-ever spontaneous ICH risk

🔮MRI is occasionally available in certain people/pts w/o ICH: may show SVD markers concerning for future ICH risk

〽️These markers are: microbleeds, superficial siderosis

1/
The populations that this might be relevant to are:
- healthy elderly
- ischemic stroke
- memory clinic
- any pt who got a brain MRI for a different indication (e.g. migraines)
- non-ICH cerebral amyloid angiopathy (CAA)

#neuroradiology #Alzheimers #stroke

2/
Read 12 tweets
Feb 20
🚨 🧵 Some pearls on cases I have seen last week during night call @bmcneurology @The_BMC 🧠
PRES, RCVS, Trigeminal autonomic cephalalgia, vertigo, IIH, hyperglycemic hyperosmolar syndrome, hyperK, SAH, a tone of CODES STROKE, a tone of seizures
#NeuroTwitter #MedEd #Neurology
1/
PRES 🗜️
⚡️huge spectrum
⚡️high index of suspicion in ptns with risk factors (often with HTN urgency, immunosuppression, sepsis) + seizures
🕵🏻‍♂️may not be posterior, may not be reversible, may not present as a syndrome!!
emcrit.org/ibcc/pres/ @PulmCrit
2/
⚡️RCVS
-observe (MRI, CTA), remove triggers, be cautious not to miss a dissection @interneurona
-pain control, this is the worst imaginable pain: Mg IV, opioids
-CaCB may help with headache - no proved benefit for vasoconstriction
@AneeshSinghalMD @CajalButterfly
@UpToDate
Read 10 tweets

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