Antoine FLAHAULT Profile picture
Jul 3 9 tweets 5 min read
1/9 - “A surge in #COVID19 hospital admissions driven by the #BA5 of #Omicron, accompanied by the inability of vaccines to prevent reinfection, has prompted health policymakers to rethink their approach to boosters.”
ft.com/content/4f71ac…
2/9 - “Research into immune imprinting, whereby exposure to the virus via either infection or vaccination determines an individual’s level of protection, is now driving the debate over the make-up of #COVID19 vaccines.”
3/9 - “Immunologists say that, >2y into the pandemic, people have acquired very different types of immunity to the #SARSCoV2, depending on which strain or combination of strains they have been exposed to — leading to big diff in #COVID19 outcomes between indiv and countries.”
4/9 - “The effect is more nuanced than ‘more times you have it, less protection you get’,” said Altmann, Imperial Collg London. “It’s more helpful to consider it as progressive fine-tuning of a huge repertoire. Sometimes this will be beneficial for the next wave, sometimes not.”
5/9 - “Our first encounter with the spike antigen, either through infection or vaccination, shapes our subsequent pattern of immunity through immune imprinting.”
6/9 - “#Omicron infection has little or no beneficial effect of boosting any part of the immune system — antibodies, B-cells or T-cells — among people who had been imprinted with earlier #SARSCoV2 variants. #Omicron is an especially stealthy immune evader.”
7/9 - “Vaccines currently in use were designed to target the virus as it first emerged from Wuhan, >2y ago. They retain high protection against severe disease and hosp admissions but their efficacy against transmission and mild infection wanes quickly, especially agnst #Omicron.”
8/9 - “99% of secondary schoolchildren tested positive for Covid antibodies from natural infection [in England]. [Now] the vast majority of Covid cases are reinfections in people whose immune defences acquired from vaccines or earlier infections do not hold up against #BA4/#BA5.”
9/9 - “Moderna and BioNTech/Pfizer have submitted lab data showing that their latest versions, targeted at Omicron, produce a potent Ab response against #BA4/#BA5. But we remain uncertain whether they will be > effective than receiving another dose of the original Wuhan vaccine.”

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More from @FLAHAULT

Jul 3
1/5 - “In 169 Georgia elementary schools, #COVID19 incidence was 35% lower in 39 schools that improved ventilation through dilution alone and 48% lower in 31 schools that improved ventilation through dilution combined with filtration.”
jamanetwork.com/journals/jama/…
2/5 - “A simulation model found that filtration with 2 high-efficiency particulate air (HEPA) cleaners alone or combined with mask wearing could potentially reduce exposure to infectious particles by an estimated 65% or 90%, respectively.”
3/5 - “Many enhancements to ventilation and filtration can be made at no or low (<$100) cost: opening windows, inspecting and maintaining HVAC systems, and using fans to increase the effectiveness of open windows. Portable HEPA air cleaners can be added for a few hundred $ each.”
Read 5 tweets
Jul 2
1/9 - “The United States is now firmly in the ‘débrouillez-vous’ era of the #COVID19 pandemic.”
theatlantic.com/health/archive…
2/9 - “Across the country, almost all gov efforts to curtail the coronavirus have evaporated. Mask mandates have been lifted on public transit. Conservative lawmakers have hamstrung what public-health departments can do in emergencies. COVID funding remains stalled in Congress.”
3/9 - “The White House and the CDC have framed #COVID19 as a problem for individuals to act upon—but action is hard when cases and hospitalizations are underestimated, many testing sites have closed, and rose-tinted CDC guidelines downplay the coronavirus’s unchecked spread.”
Read 9 tweets
Jul 1
1/9 - “‘Living with the virus’ is proving much harder than the early vaccine success suggested: this fight is far from over.”
theguardian.com/commentisfree/…
2/9 - “According to the latest numbers, released today, the UK added more than half a million new #COVID19 infections in the past week, and the estimated number of people with #COVID19 in total was somewhere between 3% and 4% of the population.”
3/9 - “Many have been rather unwell and off work or school, with the associated disruptions to education, healthcare and other vital services. These infections will also inevitably add to the toll of #LongCovid cases.”
Read 9 tweets
Jul 1
1/5 - “#COVID19 infections in England have jumped by 34% in a week as new #Omicron variants drive a wave of cases, according to the ONS (week to June 24): an estimated 1.8mn people — 3.35% of the population in England — would test positive for Covid.”
ft.com/content/f765fd…
2/5 - “Scotland remains the nation hit hardest by the surge in infections, with an estimated 288K cases — representing 5.47% of the pop. The Scottish total is up 15% on the week before. In Wales, 3.49% of people, and in Northern Ireland 3.87% would have the virus, the ONS found.”
3/5 - “The virus is spreading fast, even though between 97 and 98% of people across the UK have antibodies from vaccinations or previous infections, according to the ONS.”
Read 5 tweets
Jul 1
1/9 - Jul 01 to Jul 07 -
"Around the #COVID19 World in 80 Seconds"!

Daily epidemic 7-day forecasting for 300+ countries/ territories on our dashboard:
tinyurl.com/COVIDdashb

Data source: coronavirus.jhu.edu & ourworldindata.org/coronavirus
Powered by @ISG_UNIGE & @SDSCdatascience Image
2/9 - Western Europe
PT is the first country to see its #COVID19 #BA5 wave declining, med mortality.
- Surging/rising in the LUX (R-eff=1.35); FR=1.30; IT=1.24; AU=1.21; IRL=1.21; BE=1.19; CH=1.18; UK=1.17; ICL=1.16; NO=1.15; NL=1.15; SE=1.13; DK=1.10; DE=1.08, low-med mort. ImageImageImageImage
3/9 - East-Central Europe
- Surge/increase/plateau in their #COVID19 epid activ in Albania (R-eff=1.40); Slovakia=1.31; Bulgaria=1.29; Czechia=1.28; Serbia=1.27; Greece=1.26;Slovenia=1.23; Croatia=1.25/Lithuania=1.19;Latvia=1.11/Estonia=0.98;
No report from Ukraine since Feb 24. Image
Read 11 tweets
Jun 30
1/4 - France (R-eff=1.29) experiences a surge in #COVID19 cases driven by #BA5, low mortality. 81.2%>1 dose.
128,729 cases and 37 deaths/day to be reported by Jul 06, if at same pace.
Forecast for Jun 30 to Jul 03:
tinyurl.com/COVIDfrance
Powered by @ISG_UNIGE & @SDSCdatascience ImageImageImage
2/4 - One mainland Région is experiencing worrying and rapid surge in its #COVID19 epidemic activity, with medium mortality:
PACA (R-eff=1.32). Image
3/4 - Twelve mainland Régions are experiencing a surge in their #COVID19 epidemic activity, with low mortality:
AURA (R-eff=1.24);
Bg-Fr-C=1.23;
Bret=1.26;
Ctre-V-de-L=1.24;
Corse=1.28;
Gd-Est=1.22;
Hts-de-Fr=1.23;
Ile-de-Fr=1.24;
Norm=1.24;
Nouv-Aq=1.26;
Occit=1.28;
P-de-L=1.26. Image
Read 6 tweets

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