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Jul 27 • 11 tweets • 9 min read
.@ProfSharonLewin #AIDS2022 media briefing: As we face the COVID pandemic & ongoing humanitarian crises, we need to refocus attention on the global #HIV/#AIDS response. 1/
Annie Luetkemeyer (@annielue, @UCSF): doxycycline post-exposure prophylaxis (PEP) is safe & highly effective strategy for reducing sexually transmitted infections (gonorrhea, chlamydia, syphilis) among men who have sex with men (MSM) & transgender women (TGW). 2/
66% reduction in STIs among MSM & TGW taking #HIV #PrEP, 62% reduction among HIV+ MSM & TGW. Analysis of doxycycline resistance & effect on gut microbiome is ongoing. #AIDS2022 3/
Núria Climent (@N_Climent) presents the BarcelonaPatient, a woman who has maintained undetectable HIV viral load for 15 years after stopping antiretroviral therapy. 4/
Jana Dickter presents the @CityofHope Patient, 4th case of #HIV cure in person who received CCR5delta32 stem cell transplant for leukemia. Unlike the late @TimothyRayBrown, CityofHope Patient is oldest yet & received less immunosuppressive regimen. #AIDS2022 5/
.@ProfSharonLewin has noted that while stem cell transplant is not an option for most people with #HIV, these cases are still interesting & help illuminate the search for a cure. #AIDS2022 6/
Eli Boritz (@NIAIDNews) describes work on a biomarker to identify cells latently infected with #HIV in the viral reservoir, which Lewin has likened to a "needle in a haystack." #AIDS2022 7/
Anchalee Avihingsanon (@HIVNAT): bictegravir/FTC/TAF & dolutegravir/FTC/TDF both reduce #HIV levels in HIV/HBV coinfected people, but B/F/TAF reduced #hepB DNA & HBeAg more. Lewin says could have implications for #hepatitisB management more generally. #AIDS2022 @GileadSciences 8/
Madisa Mine describes HIV progress in Botswana, which he says is well-positioned to meet @UNAIDS 95-95-95 goals by 2030. #AIDS2022 9/
.@UCSF's advance press release (from May) on the #DoxyPEP study of doxycycline post-exposure prophylaxis to prevent STIs in HIV+ MSM/TGW & those on #prep
ucsf.edu/news/2022/05/4…
.@cityofhope's release on 4th apparent #HIV cure after a stem cell transplant for cancer.

cityofhope.org/patient-achiev…

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More from @LizHighleyman

Liz Highleyman Profile picture
Jul 28
SF declares #monkeypox a state of emergency. SF has a large & politically powerful LGBT community & one of the largest MPX outbreaks in the US on a per capita basis. 1/
SF was, I believe, 1st US city to issue an emergency & take steps like a shelter-in-place order for COVID. Not sure new emergency means in practice. What we need is more vaccines, but that’s up to the federal govt. 2/
I’m quite sure @SF_DPH (run by a gay man) won’t take steps the LGBT community opposes. I don’t see a raging debate within that community, or btwn that community & officials, like we did when the city shut down bathhouses to curb AIDS in the early ‘80s.
Read 8 tweets
Liz Highleyman Profile picture
Jul 27
City of Hope Patient is older than the few other people previously cured after stem cell transplants & he's been living with #HIV longer, suggesting this approach may be feasible for more people with both HIV & cancer. #AIDS2022 @cityofhope #AIDS 1/
bit.ly/3zDttb6
This follows the cures of @TimothyRayBrown, @londonpatient, the New York Patient -- & some count the Dusseldorf Patient -- making this the 4th or 5th such case. @pozmagazine 2/
poz.com/article/patient
Stem cell transplants are too risky to be an option for most people living with #HIV, but these findings provide clues that could help researchers develop more widely applicable approaches for long-term HIV remission. 3/
Read 4 tweets
Liz Highleyman Profile picture
Jul 27
.@CDCgov's latest COCA update on #monkeypox epidemiology, testing, vaccination & treatment. Now 3591 cases in US. 99% male at birth (possibly some trans women), 13 people female at birth (includes some trans men). All but 5 cases attributed to sex between men. 1/
These COCA updates provide a wealth of info. This one includes testing update (now capacity of 80K tests per week, but still only lesion swabs), revised simpler protocol for #TPOXX treatment. 2/

emergency.cdc.gov/coca/calls/202…
I've seen some comments on trans reporting. It doesn't say so on this slide, but @CDCgov previously reported there were no trans women & "some" trans men among monkeypox cases to date. @SF_DPH, which is more clued in on this, reports the same.
Read 4 tweets
Liz Highleyman Profile picture
Jul 27
You’re not the only one frustrated @kakape. Health officials & advocates emphasized the universal message so relentlessly that it’s very hard to shift. Anyone can get #monkeypox — but everyone isn’t getting monkeypox.
I feared back in May that this messaging strategy — entirely well-intended to reduce stigma — could backfire. It seems like the people most resistant to shifting it are straight women. 2/
Listen to what gay, bi & trans men are saying (I know it’s not unanimous). Focusing resources where #monkeypox is spreading now is the best way to both reduce suffering & protect other groups. 3/ slate.com/technology/202…
Read 4 tweets
Liz Highleyman Profile picture
Jul 25
The message that anyone can get #monkeypox isn't incorrect, but it is misleading. Fomites like bedsheets don’t carry the same risk as sexual or other close skin-to-skin contact. And unclear messaging is causing unnecessary panic. My latest for @Slate. 1/
bit.ly/3PUtmgB
You’ve all seen the warnings. You might get #monkeypox from trying on clothes. The virus lives on surfaces for months -- & it might even be airborne! Maybe you should wear a full PPE suit. 2/

But in this outbreak, #monkeypox is mostly spreading during sex between men (95% in a recent study) & like most STIs, it can be transmitted other ways as well. 3/

poz.com/article/study-…
Read 11 tweets
Liz Highleyman Profile picture
Jul 23
Here's my @pozmagazine report on the @NEJM #monkeypox study. Other reports have covered the key findings, but I'll note for the #HIV audience that 41% of cases were HIV+. The good news is that they did not have worse outcomes.
poz.com/article/study-…
"Whilst people with HIV account for more than 40% of cases so far, it is reassuring that HIV status was not linked with monkeypox severity,” said @drlaurajwaters, chair of the @BritishHIVAssoc.
The proportion of HIV+ people in this case series appears higher than HIV rates among men who have sex with men overall. It's not clear if HIV might be associated with greater monkeypox susceptibility, though it seems possible that immunosuppression could play a role.
Read 5 tweets

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