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Aug 5 • 4 tweets • 3 min read
This Mendelian randomization study provides evidence that genetically predicted walking may reduced the risk of Alzheimer’s disease.
- Genetically predicted higher levels of walking were found to decrease the risk of AD.
- Interestingly, the study failed to find any associations between genetically predicted overall activity, sedentary behavior, and moderate-intensity activity with AD.
Using a two-sample mendelian randomization analysis to explore the relationship between physical activity and Alzheimer’s disease (open access)

doi.org/10.1038/s41598…

#aging #Alzheimers #AlzheimersDisease #exercise #muscle #strength #lift #cardio #hiit

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More from @nick_krontiris

Nick Krontiris Profile picture
Aug 5
This one tried to provide updated estimates on the prevalence and determinants of overweight and obesity in Europe.

It suggests that half of the European adult population is overweight and almost one in every eight are obese. Image
- Obesity prevalence was 13% in 2017-2018, with higher rates in women, older adults, and those with a lower socioeconomic status.
- Large variability was observed across countries, with obesity prevalence ranging between 8% in Italy and 21% in Romania.
Read 5 tweets
Nick Krontiris Profile picture
Aug 5
This systematic review and meta-analysis of randomized controlled trials finds that resistance training exercise may promote increases in bioelectrical phase angle, an indicator of body cell mass and cellular health, in older adults.
- Phase angle is an indicator of body cell mass and cellular health, that is also moderately associated with muscle quality.
- Resistance training programs lasting ≥ 8 weeks were found to result in phase angle increases in participants aged ≥ 60 years.
Read 5 tweets
Nick Krontiris Profile picture
Aug 5
In line with several previous studies, this one found hypoglycemia (glucose <3.0 mmol/L) to result in declines in important aspects of cognitive function, with the decline being consistent in adults with or without diabetes and largely independent of clinical factors.
- In this study, the authors enrolled clinically distinct subgroups of people with diabetes, and control subjects, using the same methodology allowing for direct comparison between different diabetic phenotypes and subjects without diabetes.
- Hypoglycemia deteriorated cognitive performance in all groups of participants to a similar extent, with effect sizes ranging from small to medium.
Read 5 tweets
Nick Krontiris Profile picture
Aug 5
This one found an inverse, independent, and graded association of cardiorespiratory fitness with mortality risk across the age spectrum (including septuagenarians and octogenarians), men, women, and all races.
- This is an analysis of more than 750,000 U.S. veterans, which included a large numbers of septuagenarians, octogenarians, African Americans, Hispanics, Native Americans, and women.
- During a median follow-up period of 10.2 years and more than 7.8 million person-years of observation, adjusted associations of CRF and mortality risk were inverse and strongly graded across the age spectrum, sex, and race.
Read 6 tweets
Nick Krontiris Profile picture
Aug 4
The findings of this Mendelian randomization and protein-truncating variant analysis do not support a causal association between GDF-15 plasma levels and human cardiometabolic disease factors in humans.
- Related:

link.springer.com/article/10.100…
- The analysis confirmed strong correlations of GDF15 plasma levels with a range of clinical parameters (e.g. age, smoking and BMI) and human diseases (e.g. diabetes, cardiovascular and respiratory disease), as well as several inflammatory biomarkers.
Read 8 tweets
Nick Krontiris Profile picture
Aug 4
This study examined the effect of traditional-set vs. cluster-set structures, matched for total repetitions per session at the same relative load, during an 8-week high-load bench press training program on body composition, and measures of muscle hypertrophy and strength.
- Site-specific muscular hypertrophy of the proximal and middle regions of the pectoralis major improved to a greater extent over the intervention period in traditional compared with cluster sets.
- Cluster sets were found to increase body mass compared with traditional, with no between-group differences being observed for remaining outcomes of site-specific muscular hypertrophy or body composition.
Read 7 tweets

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