#Swedish #Covid study confirming the detrimental long-term effects of the coronavirus on the immunesystem akin to #HIV
Can this finally persuade #Sweden to take this virus seriously? 😭🙏🏼 liu.se/en/news-item/s…
Can this finally persuade #Sweden to take this virus seriously? 😭🙏🏼 liu.se/en/news-item/s…
”The effects on the T cells of the immune system are interesting and mixed. Some of them are still activated long after the disease episode, while others are ‘fatigued’ and cannot function normally. We see similar effects on patients with a chronic HIV infection.”
- SARS-CoV-2-infected individuals have prolonged reduction of CD3+ T Cells
- COVID-19 patients have a sustained, elevated CD8+ TEMRA population
- COVID-19 patients have a sustained, elevated CD8+ TEMRA population
- SARS-CoV-2 induces a long-term altered exhausted CD57+CD8+ T cell population
- SARS-CoV-2 gives rise to high expression of LAG-3, TIM-3 and PD-1 that is maintained for a prolonged duration, indicative of suboptimal T cell responsiveness
- SARS-CoV-2 gives rise to high expression of LAG-3, TIM-3 and PD-1 that is maintained for a prolonged duration, indicative of suboptimal T cell responsiveness
”The hyper-activation of T cells is a well-studied mechanism in chronic viral infections and is often dependent on the levels of viral persistence in the circulation…”
”The reason for the prolonged activation of T cells in COVID-19 could be owing to the persistence of viral antigens in the bone marrow, that indirectly affect the circulating lymphocytes.”
frontiersin.org/articles/10.33…
frontiersin.org/articles/10.33…
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