2 of 10/We are excited to announce that the adverse reaction to drugs biologics and latex (ARDBL) committee of the @AAAAI_org has an #inpress workgroup report on allergy documentation in the EHR. jaci-inpractice.org/article/S2213-…
3 of 10/ In this article: current state of allergy #ehr documentation, definitions, reconfigurations, and recommendations✔️#bestpractices in documentation for #penicillin allergy ✔️what to include and what not to include in the allergy list
4 of 10/ Do not include environmental allergens (pollen, cat, dust) in the allergy list! if a patient has allergic rhinitis, these allergens should be listed in the problem list.
5 of 10/ the allergen: can be a drug, foods, chemical, and other agent. Be specific! entering “ampicillin” would be preferred to entering “penicillins,” “sulfamethoxazole” is preferred to “sulfa.” Generic is preferred to a name brand.
6 of 10/the reaction: choose coded reactions when available and enter additional details in the free text. Remember that there is a history related to the reaction—a drug allergy history!
7 of 10/the reaction type: the most important aspect here is to change the reaction type to “intolerance” when the reaction is clearly not allergic (eg., headache, fatigue, etc). This will change how allergies appear in the list in many EHRs. Okay to leave unspecified.
8 of 10/ the severity: mild, moderate, or severe. For allergy, grade based on signs and symptoms; for example, itching =low, urticaria=medium severity, #SCAR and #anaphylaxis =high. For intolerance, grade by interference with life.
9 of 10/have more to say? Use the free text for timing, management, dates of photos or consultation notes. Include the results of allergy testing. Include if patient has tolerated a related drug (eg, "anaphylaxis to cefazolin, tolerates other beta-lactams").
We allergists have historically considered the risk of “cross reaction” between FQs ~30%. These are great new real-world data with a practical inpatient application for individuals with a FQ allergy label and rxn suggestive of immediate HSR. @PaulSaxMD@BrianTanChan /1
This study is unlikely to be capturing true “cross reaction” rate because these individuals did not have a confirmed FQ immediate hypersensitivity and there is likely a natural selection bias with respect to which patients were challenged to another FQ and which were not. /2
The prospective observational study that is the largest I know of evaluated patients a median on 9.5 months after their FQ rxn and prospectively assessed “cross reaction” with single blind placebo controlled challenges and the rates were higher : pubmed.ncbi.nlm.nih.gov/28497922/ 3
ONE-To treat acute urticaria (hives), antihistamines should be nonsedating and scheduled (not diphenhydramine PRN). Allegra/fexofenadine and Zyrtec/cetirizine have large therapeutic windows and are used safely at 4+ times the daily allergic rhinitis dose/2
TWO-Angioedema in an adult without skin itching/hives/rash—check if they on an ACE inhibitor! Although ~10% get it w/in 30d, many happen after years of uneventfully being on it /3 ncbi.nlm.nih.gov/pmc/articles/P…
2/Allergy symptoms were slightly more with @moderna_tx (2.20% vs 1.95%; p=0.03). Although no difference in #anaphylaxis incidence by vaccine manufacturer, but different #anaphylaxis criteria led to different estimates (Brighton/NIAID/FAAN: from 1.1-2.5/10K administrations).
3/Similar to @CDCgov reports, the 16 #anaphylaxis patients were largely female (94%); 10 (63%) had prior allergy history and 5 (31%) had prior anaphylaxis history. BUT, we estimate that ~4K @MassGenBrigham employees with severe allergy histories were safely vaccinated.
1/Brief #COVID19vaccine allergy update: LARGE LOCAL REACTIONS! These all were after #Moderna. Itchy, swollen, erythema, edema. Comes on late (>5 days) and can last weeks .Tx is symptomatic: antihistamine (e.g., fexofenadine), NSAID/Tylenol, ice.
2/ Importantly, you CAN still get the second dose! In the #modernavaccine trial, delayed large locals like these occurred 4x less with 2nd dose than 1st dose. Fewer large locals AND more efficacy, sign me up!
*Potential #anaphylaxis 175 of 1,893,360 1st doses of @pfizer vaccines (0.009%; 90 per million)
*Confirmed #anaphylaxis, 21 of 1,893,360 1st doses of @pfizer vaccines (0.0011%; 11 per million)
-->Better than we thought (1 per 100,000)but greater than usual 1 per million)/2
*17 of 21 Anaphylaxis cases (81%) had allergy history; 7 of 21 (33%) had prior anaphylaxis
*Anaphylaxis occurred a median of 13 min (2–150 min) after vaccination; 71% occurred within 15 min (i.e., CDC recommended waiting/observation time)
*Follow-up for 20 patients & 100% OK /3
2/#allergy and #anaphylaxis can happen to any #drug or #vaccine, but reactions to #COVID19vaccine are exceedingly rare (~6 in >300K vaccinations so far--> 0.002%). #vaccines have always been a rare cause of allergic reactions in healthcare.