I've scheduled my #SARSCoV2 COVID-19 bivalent booster! 🗓️💉How about you?

Even with immune-evasive variants, vaccinations can still help boost your protection, especially from bad outcomes! Every little bit might make the difference this autumn - you can help! 😁✊🏻
If, like me, you live somewhere where only the BA.1 bivalent is currently available, I would still recommend it. We don't know what variant may dominate, (but it's likely Omicron, like BA.1), & given how things are looking, I wouldn't wait for 2023 to get boosted.
Finally, if you recently (~3 months) had SARS-CoV-2 (in most places, likely BA.5), you likely still are still benefiting from the immunity from infection & so most advice is to wait a bit to get boosted!
For people in #Switzerland #Schweiz , you can find out more about how to make an appointment for a #SARSCoV2 booster (and your eligibility after infection or your most recent booster) here!: covid19.impf-check.ch

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More from @firefoxx66

Sep 22
What should we expect from #SARSCoV2 this autumn?

I think it would be smart to prepare for both an increase in #COVID19 due to seasonal (behavioural) change & a new variant.
As so many others have elegantly illustrated, new lineages of SC2 are sparking interest.

1/17
Up front, I want to give a huge shout-out to @CorneliusRoemer who does a fantastic job keeping an eye on variants, particularly for @nextstrain & #Switzerland. But also for fantastic tireless work by @PeacockFlu @theosanderson @siamosolocani @SolidEvidence & more

2/17
Since the dominance of BA.5 (22B), most of the world hasn't seen much else move in (though in some places BA.4/22A hangs on), with the exception of India & BA.2.75 (22D).

covariants.org/per-country?co…

3/17
Read 17 tweets
Sep 21
📡CoVariants.org Update📡
This update doesn't impact the visualizations or the data, but @MoiraZuber deserves a public appreciation thread thanks to her tireless efforts & recent refactoring achievements - so here it is!

1/7
CoVariants is a labour of love - I'm always trying to squeeze it in between the million other things I 'should' be doing (which hopefully lead to publications, the hard currency of academia). Because of this, the time I can put into CoVariants is sadly limited 😞⌛️

2/7
Thus, CoVariants code is all a little bit hacked together in spare minutes. As a result, the main processing script had grown arms, legs, toes & tentacles - it took >2.5 hours to run!! 🧌⏱️
Obviously, very sub-par for development!

3/7
Read 7 tweets
Sep 7
Huge thanks to @HopkinsMedicine @AmaryFaln @hmostaf2 for sending along the first #Enterovirus #D68 #EVD68 sequences of 2022! 🙏🏻🚀

You can see them in the full-genome & VP1 builds:
nextstrain.org/enterovirus/d6…
nextstrain.org/enterovirus/d6…

1/5
Note that for the moment I don't have anything but year for these sequences, so month is being inferred by the pipeline - note the wide confidence interval on the date!

However, zooming into the VP1 build, we can see some interesting connections...

2/5
All part of the B3 clade, 1 seq attaches to autumn 2021 circulation in Europe/USA (1), 1 attaches back to European circulation in autumn 2019 (2), and the rest attach back to USA+ circulation in autumn 2019 (3).

3/5
Read 5 tweets
Sep 4
📡#Enterovirus #D68 #EVD68 builds on @nextstrain are now updated 📡

You can check out the VP1 (single-gene) build (nextstrain.org/enterovirus/d6…) & full-genome builds (nextstrain.org/enterovirus/d6…).

I'll give a brief overview of a few things of interest...

1/7
The VP1 #EVD68 build lets us include the most sequences, so I'll focus on that here - though full-genome has many other advantages!

No 2022 seqs yet (got my 👁️peeled!), but there are some from 2021 - from Europe & N America. These stem from the B3 & A2 clades.

2/7
And more specifically, are related to seq clusters that circulated in 2018/2019.

Huge thanks to @HopkinsMedicine @AmaryFaln @NIBSC_MHRA Javier Martin, Alison Tedcastle @UKL_Leipzig Mario Hönemann @CHUDijon Alexis de Rougemont, Isabelle Schuffenecker & more for these seqs!

3/7
Read 7 tweets
Sep 2
Recently I've heard from collaborators in the US & Europe that #Enterovirus #D68 #EVD68 cases are on the rise.

EV-D68 is what I worked on pre-pandemic, & hope to go back to.
A significant autumn 2022 wave has been a recent concern.

So what is D68 & what might this mean?

1/17 From https://syndromictrends.com/ - doesn't break down betwe
#EVD68 is a Picornavirus - a diverse family of viruses. And Enteroviruses are pretty diverse themselves: from Poliovirus, which can cause serious neurological illness, to Rhinovirus - what's behind the common cold 🤧 (and even more in between).

2/17
One of the most notable things about #EVD68 is that in Europe & North America it's historically had biennial autumn outbreaks: in 2014, 2016, & 2018. Also predicted in 2020... but that didn't happen due to pandemic!
Following that pattern, 2022 would be an outbreak season🗓️

3/17
Read 18 tweets
Sep 1
"Are we better prepared?" asks @EckerleIsabella as she closes #SSM @SwissMicrobe with her keynote on challenges in prevention & preparedness for emerging viruses.
#SARSCoV2 & #monkeypox have highlighted these issues; what do we know & where do we stand?

1/N Image
Perhaps particularly of note are viruses that aren't entirely new, but keep popping up, or appear in new hosts, new places, or with new symptoms a while after identification. How & how often does this happen?

Others we know well & have fought before, but appear again!

2/N Image
Understanding viral emergence is also not just for viral biologists: there are so many factors that provide influence, from that virus and host to environmental, anthropic, and human-animal interface.

3/N Image
Read 8 tweets

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