🚨Another study finds #microclots in #LongCovid
“We would argue that whilst there may be many mechanisms at play in the pathogenesis of Long Covid, the common pathological process is thrombotic endotheliitis.”medrxiv.org/content/10.110…
“We would argue that whilst there may be many mechanisms at play in the pathogenesis of Long Covid, the common pathological process is thrombotic endotheliitis.”medrxiv.org/content/10.110…
“We conclude that presence of microclotting, together with relatively high levels of six inflammatory molecules known to be key drivers of endothelial and clotting pathology, points to thrombotic endotheliitis as a key pathological process in #LongCovid.”
“This may be characterized by the formation of anomalous fibrinaloid microclots, hyperactivated platelets, endotheliitis and elevated levels of prothrombotic inflammatory molecules which interact with each other as well as with platelets and the endothelium”
“Up to now, we have demonstrated significant #microclot formation & platelet activation in all #LongCovid patients whom we have studied using fluorescence microscopy”
“..as well as detailed proteomics analysis revealing several-fold increased concentrations of inflammatory molecules entrapped within the microclots.”
“Given the significant increase in the rates of thrombotic events following even a mild infection it is imperative that the thrombotic endotheliitis is treated urgently.
There is an immediate need for a microclot detection method that can be rolled out for clinical use.”
There is an immediate need for a microclot detection method that can be rolled out for clinical use.”
“We argue that such a microclot detection method together with the demonstration of relatively high levels of the six molecules described in this paper, would be good evidence for an ongoing thrombotic endotheliItis”
“The optimal therapeutic regimen is yet to be defined; however given the complex pathophysiology, such therapy is likely to incorporate antiplatelet drugs, as well
as agents acting on the enzymatic pathway of coagulation” #LongCovid
as agents acting on the enzymatic pathway of coagulation” #LongCovid
Absolutely amazing work #TeamClots — @resiapretorius @dbkell @doctorasadkhan
You continue to lead the way, now it’s time for everybody else to pick up the slack !! Let’s GO!
You continue to lead the way, now it’s time for everybody else to pick up the slack !! Let’s GO!
@calirunnerdoc @farid__jalali @AngelaReiersen @tnicholsmd @zeynep @MVGutierrezMD @LekshmiMD @WesElyMD @denise_dewald @lisa_iannattone @chrischirp @TraceySpicer @benjmueller @ZekeEmanuel @zalaly @LauraMiers @EricTopol @fearnley_k @dgurdasani1 @drjudymelinek @luckytran @Bob_Wachter
@ahandvanish @ShaneyWright @HarryLeeming @clarejdaly @j_b_kennedy @RaviHVJ @CortJohnson @mattbc @elisaperego78 @D_Bone @dianaberrent @exceedhergrasp1 @stuartamalcolm @jencurtinmd @phylogenomics @organichemusic @myrabatchelder @LongCovidSOS @long_covid @LongCovidKids @EdoajoEric
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