Teddy Hla Profile picture
Oct 22 13 tweets 5 min read
Final session :: Lisanne Roesthuis and Annemijn Jonkman - Lung uss. What’s the thickness of diaphragm
Goal / make it comparable - 1. Patient position : supine or semi recumbent 2.probe selection : cardiac probe. 3. Measurements : thickening fraction 4. But if ventilated then it’s harder to separate pt v machine #LIVES2022 #ventilation #POCUS @ESICM
Between pleural and peritoneal line
Measure in the zone of apposition. I.E., lung needs to be sliding in and out -> can be tricky to acquire. Intercostal approach. Mid. Axillary line. Perpendicular to skin. Audience : difficult to obtain views. But perhaps shorter learning curve than echo 👍🤞
— having ascitic fluid or pleural fluid doesn’t change the measurements. Measure “end expiratory thickness” when there’s no activity. Measure for 3 breaths and average. Thickening fraction TFdi = (Tei-Tee)/Tee * 100%. #POCUS #LIVES2022 #ventilation
- “M” mode. Adjust sweep speed to 10mm/s to capture multiple breaths. End expiratory thickness affected by body position + gender. TFdimax < 20% ~ diaphragm weakness. pubmed.ncbi.nlm.nih.gov/26167730/ . If during assist target 15-30%-less than 15% may be over assist
However there’s new paper : potentially poor relation between TFdi and Delta P di. pubmed.ncbi.nlm.nih.gov/34788380/ so questions : TFdi does not = force generation. 2nd ?: does zone of apposition reflects the whole diaphragm ?
To me this is again like using Poes. It reflects central dorsal side more than ventral.
Next : Diaphragm Excursion. Use liver as acoustic window. Diaphragm moves caudally during inspiration I.E., towards probe. M line perpendicular to diaphragm at 10mm/a sweep speed .
Main question : diaphragm moving caudally or paradoxically ? Diaphragm dysfunction : tidal excursion< 1cm and maximal breath <2.5 cm. Compare L and R. image acquisition of R is easier.
Take home message : uss of diaphragm is non invasive. Useful. Potentially other tools and uses too. E.g., respiratory muscles. See pubmed.ncbi.nlm.nih.gov/32386831/
Question from audience :: what do you with this ? Answer : difficult as need t be in the context of everything. For example Potential consideration for diaphragmatic pacing etc.
More complex measurements — usually trickle down technology already used in echo - Speckle tracking. But what’s signal to noise ratio. More to think.🤔All in all a very exciting area with potential applications and perhaps transfer learning with ?chest wall nerve blocks , echo 🤓

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More from @teddyhla

Oct 24
Amsterdam UMC on Implementation: @drPaulElbers Conference conflicts of interest : chair of data science edition.
"Working AI to Implementation"
#criticalcare #DataScience #ai #aitobedside #LIVES2022
@ESICM
@drPaulElbers @ESICM PacMed Model to help discharge patients from ICU. Autokinetics for antibiotic dosing.

These 2 are currently implemented. @patrickthoral also involved in discharge models.
@drPaulElbers @ESICM @patrickthoral - ICU natural habitat
- large vol of data
- frequent decision making
BUT there is a problem in ICU and data.
- high variability
pubmed.ncbi.nlm.nih.gov/36173632/
Read 17 tweets
Oct 24
NEXT: Who's "high risk" in ICU? Nicolas Bennett - Zurich, Switzerland.
reminds me of NELA score development in UK.
Declaration : he now works for industry (known side effect for medics doing data science )
@ESICM #criticalcare #ai #datascience #LIVES2022
@ESICM Interesting : eventually end up writing R package. cran.r-project.org/web/packages/r…

#sepsis classification using MIMIC-3 - time series data. Time-series classficiation.
Image
Read 12 tweets
Oct 24
Starting with "Whats *HOT* in data science?" Kirsten COLPAERT
- hype cycle for data science & ML in 2022.
- innovation trigger -> peak of inflated expectations -> trough of disillusionment
#LIVES2022
#datascience #WeAreICU #TogetherICU #IntensiveCare #CriticalCare @ESICM
Still some time for newer tools. Aiming for path towards productivity. Image
Potential usage of "Synthetic data" to "preserve privacy" and "augment unbalance/or biased data". This is potentially interesting as it allows more transportability of models from one health care system to others.
Read 10 tweets
Oct 24
@ESICM #LIVES2022 #ventilation
#ARDS #Steroids. This morning I covered "4 key questions on NIV" and "steroids". Here is a collection of those threads.
1/n
@DrLeoHeunks 2. Claude Guerin on COVID vs. Non-covid NIV. threadreaderapp.com/thread/1584445…
3/n
Read 10 tweets
Oct 24
Next: Derek Angus : motivation to "TEST" steroids in COVID-19 ARDS.
Doctors "love" giving steroids. How about we "test" it?
#LIVES2022
#ventilation
#ards #steroids @ESICM
@ESICM steroids : long list of side effects ( 2' bac infection, impair host response, impair viral clearance).
- which steroid, when, what dose, how long
- unclear if all COVID patients in hospital should receive Steroids.
#LIVES2022
#steroids #ards
@ESICM large RCTs 1. RECOVERY(UK) - not 20mg in DEXA-ARDS but 6mg. in the O2 receiving group, Dexa seems to be better. Ventilated patient - very strong signal too of dexamethasone being better.
#COVID19 #steroids #LIVES2022 @ESICM
Read 13 tweets
Oct 24
NEXT: Clinical question : ARDS and steroids-sensitive patterns by President-Elect @ElieAzoulay5
lots of questions: why? how ? phenotypes? timing? dose? are we missing "systemic vasculitis,etc" behind defn ARDS?
#LIVES2022
#ventilation
#steroids #ARDS @ESICM
@ElieAzoulay5 @ESICM Refreshing ARDS definition. Berlin definition needs further updates (more on this later). 🤓
Pathological : DAD : Diffuse Alveolar Damage" has many causes - most of them we wont discuss steroid use at all.
@ElieAzoulay5 @ESICM thus DAD pathological diagnosis is not helpful to ask clinical question of steroids.
Interesting finding in autopsy data in ARDS. #LIVES2022
Read 10 tweets

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