Final session :: Lisanne Roesthuis and Annemijn Jonkman - Lung uss. What’s the thickness of diaphragm
Goal / make it comparable - 1. Patient position : supine or semi recumbent 2.probe selection : cardiac probe. 3. Measurements : thickening fraction 4. But if ventilated then it’s harder to separate pt v machine #LIVES2022#ventilation#POCUS@ESICM
Between pleural and peritoneal line
Measure in the zone of apposition. I.E., lung needs to be sliding in and out -> can be tricky to acquire. Intercostal approach. Mid. Axillary line. Perpendicular to skin. Audience : difficult to obtain views. But perhaps shorter learning curve than echo 👍🤞
— having ascitic fluid or pleural fluid doesn’t change the measurements. Measure “end expiratory thickness” when there’s no activity. Measure for 3 breaths and average. Thickening fraction TFdi = (Tei-Tee)/Tee * 100%. #POCUS#LIVES2022#ventilation
- “M” mode. Adjust sweep speed to 10mm/s to capture multiple breaths. End expiratory thickness affected by body position + gender. TFdimax < 20% ~ diaphragm weakness. pubmed.ncbi.nlm.nih.gov/26167730/ . If during assist target 15-30%-less than 15% may be over assist
However there’s new paper : potentially poor relation between TFdi and Delta P di. pubmed.ncbi.nlm.nih.gov/34788380/ so questions : TFdi does not = force generation. 2nd ?: does zone of apposition reflects the whole diaphragm ?
To me this is again like using Poes. It reflects central dorsal side more than ventral.
Next : Diaphragm Excursion. Use liver as acoustic window. Diaphragm moves caudally during inspiration I.E., towards probe. M line perpendicular to diaphragm at 10mm/a sweep speed .
Main question : diaphragm moving caudally or paradoxically ? Diaphragm dysfunction : tidal excursion< 1cm and maximal breath <2.5 cm. Compare L and R. image acquisition of R is easier.
Take home message : uss of diaphragm is non invasive. Useful. Potentially other tools and uses too. E.g., respiratory muscles. See pubmed.ncbi.nlm.nih.gov/32386831/
Question from audience :: what do you with this ? Answer : difficult as need t be in the context of everything. For example Potential consideration for diaphragmatic pacing etc.
More complex measurements — usually trickle down technology already used in echo - Speckle tracking. But what’s signal to noise ratio. More to think.🤔All in all a very exciting area with potential applications and perhaps transfer learning with ?chest wall nerve blocks , echo 🤓
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NEXT: Who's "high risk" in ICU? Nicolas Bennett - Zurich, Switzerland.
reminds me of NELA score development in UK.
Declaration : he now works for industry (known side effect for medics doing data science ) @ESICM#criticalcare#ai#datascience#LIVES2022
Still some time for newer tools. Aiming for path towards productivity.
Potential usage of "Synthetic data" to "preserve privacy" and "augment unbalance/or biased data". This is potentially interesting as it allows more transportability of models from one health care system to others.
Next: Derek Angus : motivation to "TEST" steroids in COVID-19 ARDS.
Doctors "love" giving steroids. How about we "test" it? #LIVES2022 #ventilation #ards#steroids@ESICM
@ESICM steroids : long list of side effects ( 2' bac infection, impair host response, impair viral clearance).
- which steroid, when, what dose, how long
- unclear if all COVID patients in hospital should receive Steroids. #LIVES2022 #steroids#ards
@ESICM large RCTs 1. RECOVERY(UK) - not 20mg in DEXA-ARDS but 6mg. in the O2 receiving group, Dexa seems to be better. Ventilated patient - very strong signal too of dexamethasone being better. #COVID19#steroids#LIVES2022@ESICM
NEXT: Clinical question : ARDS and steroids-sensitive patterns by President-Elect @ElieAzoulay5
lots of questions: why? how ? phenotypes? timing? dose? are we missing "systemic vasculitis,etc" behind defn ARDS? #LIVES2022 #ventilation #steroids#ARDS@ESICM
@ElieAzoulay5@ESICM Refreshing ARDS definition. Berlin definition needs further updates (more on this later). 🤓
Pathological : DAD : Diffuse Alveolar Damage" has many causes - most of them we wont discuss steroid use at all.
@ElieAzoulay5@ESICM thus DAD pathological diagnosis is not helpful to ask clinical question of steroids.
Interesting finding in autopsy data in ARDS. #LIVES2022