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Nov 5 • 9 tweets • 4 min read
In this one, muscle fat infiltration was found to be associated with a higher risk of NASH and significant liver fibrosis, regardless of muscle mass, function, or strength, in patients with severe obesity.
- The degree of NASH in liver histology presented as steatosis, and ballooning, and liver fibrosis was correlated with fat infiltration in the muscle assessed, the psoas.
- Psoas muscle fat infiltration was associated with a 2.3-fold increased risk for NASH and a 2.9-fold increased risk for significant liver fibrosis.
- Muscle mass and muscle strength were not associated with NASH or significant liver fibrosis.
- Individuals with NASH or significant liver fibrosis had a higher appendicular skeletal muscle mass, which was maintained after adjusting for BMI or height.
- Unexpectedly, there was no difference in psoas density between groups, and psoas muscle area was actually higher in the NASH group.
- The findings are consistent with previous studies in humans.

Refs:

For more about muscle fat and its consistent association with several diseases:

twitter.com/search?q=myost…
Muscle fat contents rather than muscle mass determines nonalcoholic steatohepatitis and liver fibrosis in patients with severe obesity

doi.org/10.1002/oby.23…

#MetabolicSyndrome #NAFLD #MAFLD #exercise #muscle #strength #lift #GetStrong #cardio #hiit

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More from @nick_krontiris

Nick Krontiris Profile picture
Nov 5
This one in individuals at clinical high-risk for psychosis suggests that the beneficial impact of omega-3 PUFAs on clinical symptoms in psychosis is mediated, at least in part, through the complement and coagulation pathway proteins. Image
- The complement system is a network of proteins that play an important role in host defense and inflammation.
- The coagulation system, you guessed it, is the good ol' system that is made up of blood cells and proteins, responsible for creating blood clots to allow for rapid healing and prevention of excessive bleeding.
Read 9 tweets
Nick Krontiris Profile picture
Nov 5
Here, 4000 IU/day vitamin D supplementation in older adults aged 50–80 years with overweight or obesity and vitamin D deficiency had no effect on gait speed either with or without exercise, but combined with exercise, it was more likely to result in decreased waist circumference. ImageImageImageImage
- Further, Vitamin D supplementation taken alone also reduced stair climb times, an effect not observed in combination with exercise, but had no beneficial effects on any other biochemical, body composition or physical function parameters.
- Finally, vitamin D supplementation increased muscle density during exercise, but only in men and "however, this finding should be interpreted with caution given the low numbers in our subgroups".
Read 4 tweets
Nick Krontiris Profile picture
Nov 5
Here, physically inactive primary care patients aged between 19 and 80 years living in Spain, were more likely to have a reduced risk of mortality by increasing their physical activity, even in doses below the recommended levels. Image
- Physical activity levels in this inactive population of primary care patients translated into risk reductions in mortality.
- These benefits followed a clear dose–response relationship, in which mortality started to fall even with only small increases in physical activity.
Read 5 tweets
Nick Krontiris Profile picture
Nov 5
In this one in mice, branched-chain amino acid (BCAA) ingestion suppressed chronic detraining-induced reductions of skeletal muscle mitochondrial content. ImageImage
- The BCAA dose was 0.6 mg/g of body weight twice daily for 2 mouse weeks of detraining, which translates roughly into ~50 mg/kg of body weight for 560 human days of detraining.
- BCAA supplementation suppressed the reduction of mitochondrial enzyme activities and protein content in skeletal muscle.
Read 20 tweets
Nick Krontiris Profile picture
Nov 5
In this one, Lawrence Mandarino and colleagues clearly show that fuel choice during mild exercise is unaffected by insulin resistance, doing away with the notion that insulin resistant muscle may use and sometimes prefer lipid oxidation. ImageImage
- There is evidence that resting, insulin-resistant skeletal muscle prefers to oxidize carbohydrate. This contrasts with a preference for lipid oxidation in skeletal muscle from active, fit, healthy individuals.
- This preference for carbohydrate in resting muscle has been proposed to be responsible for insulin resistance in skeletal muscle, at least in part.
Read 14 tweets
Nick Krontiris Profile picture
Nov 5
In this one in mice, branched-chain amino acid (BCAA) ingestion suppressed chronic detraining-induced reductions of skeletal muscle mitochondrial content. ImageImage
- The BCAA dose was 0.6 mg/g of body weight twice daily for 2 mouse weeks of detraining, which translates roughly into ~50 mg/kg of body weight for 560 human days of detraining.
- BCAA supplementation suppressed the reduction of mitochondrial enzyme activities and protein content in skeletal muscle.
Read 20 tweets

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