#Depression is associated with alterations in corticostriatal reward circuitry. One pathophysiological pathway that may drive these changes is #inflammation... 
...This study examined whether increased inflammation in depression affects corticostriatal reward circuitry to lead to deficits goal-directed motor behavior. Resting-state fMRI maging was conducted on 48 medically stable, unmedicated outpatients with major depression...
...Increased CRP was associated with decreased connectivity between ventral striatum and ventromedial prefrontal cortex (vmPFC) (corrected P<0.05), which in turn correlated with increased anhedonia (R=−0.47, P=0.001)...
...These findings suggest that decreased corticostriatal connectivity may serve as a target for anti-inflammatory or pro-dopaminergic treatment strategies to improve motivational and motor deficits in patients with increased inflammation, including depression.
Source:
nature.com/articles/mp201…
#Neuropsychiatry #neuroscience #psychiatry #NeuroTwitter #psychtwitter
nature.com/articles/mp201…
#Neuropsychiatry #neuroscience #psychiatry #NeuroTwitter #psychtwitter
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