Using Mendelian randomization analysis and conventional analysis, this one finds fat mass to be causally and linearly associated with all-cause mortality, while showing that the obesity paradox found in observational analyses can be explained by high-risk lifestyle choices. 
- The phenomenon where a higher BMI correlates with lower mortality risk has been called the obesity paradox.
- In order to investigate the association between fat mass and mortality and mortality not only among the whole population, but to be able to stratify in subgroups as well, the authors used six well-known lifestyle risk factors to assess high/low risk lifestyles.
- The authors included diet, physical activity, smoking, alcohol drinking, sleep and psychological health as the main six lifestyle risk factors.
- Separating fat mass from whole body mass, this Mendelian randomization analysis demonstrated a linear relationship between genetically-predicted fat mass and all-cause, and cause-specific mortality.
- This relationship did not change in stratification analyses of different lifestyle factors.
- On the other hand, the conventional observational analysis indicated the fat mass, as reflected by the fat mass index, has a J-shaped relationship with mortality.
- But, for all of the lifestyle factors, the J-shaped association with mortality was attenuated and the association became monotonic in the stratum of ≥4 low-risk lifestyle factors, while the increased risk at lower levels was accentuated with fewer low-risk lifestyle factors.
- Among the six individual lifestyle factors, adequate physical activity reversed the negative correlation between the fat mass index and mortality to positive.
- Therefore, this data does not support the obesity paradox, and actually explains the elevated mortality risk in people with low fat mass by their high-risk lifestyle choices, especially inadequate physical activity.
- Further, these results support a direct, causal relationship between fat mass and mortality.
Association between fat mass and mortality: analysis of Mendelian randomization and lifestyle modification
doi.org/10.1016/j.meta…
#Obesity #MetabolicSyndrome #longevity #exercise #Workout #GymLife #GymTime #muscle #strength #lift #GetStrong #cardio #hiit
doi.org/10.1016/j.meta…
#Obesity #MetabolicSyndrome #longevity #exercise #Workout #GymLife #GymTime #muscle #strength #lift #GetStrong #cardio #hiit
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