Now that's interesting.
This one in mice suggests that chronic glucagon agonist-mediated weight loss is due to low plasma amino acid availability, which results in increased energy expenditure and subsequent body weight loss.
This one in mice suggests that chronic glucagon agonist-mediated weight loss is due to low plasma amino acid availability, which results in increased energy expenditure and subsequent body weight loss.
- A long-acting glucagon analog led to glucagon-mediated body weight loss which was intrinsically linked to hypoaminoacidemia.
- Low plasma amino acids were found to be a pre-requisite for this glucagon-mediated energy expenditure and weight loss.
- As a result of the treatment, the mice lost lean mass and strength.
- Preventing hypoaminoacidemia with a high protein diet also prevented weight loss in obese mice, but also blunted the reduction in lean mass and grip strength, an effect which became less pronounced over the course of the study.
- BUT! High-protein feeding did not blunt the beneficial effects of glucagon signaling on glycemia, plasma lipids, or hepatic steatosis:
i.e., the mice still were obese, but the chronic glucagon receptor agonist treatment still led to improvements in glycemia and hepatic steatosis!
Hypoaminoacidemia underpins glucagon-mediated energy expenditure and weight loss (open access)
doi.org/10.1016/j.xcrm…
#nutrition #Diet #MetabolicSyndrome #Diabetes #Obesity #InsulinResistance #NAFLD #Cholesterol #Triglycerides #protein
doi.org/10.1016/j.xcrm…
#nutrition #Diet #MetabolicSyndrome #Diabetes #Obesity #InsulinResistance #NAFLD #Cholesterol #Triglycerides #protein
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