🧵1. Thank you to the partners who have provided financial support to the the Kidney Institute of New Mexico.

#MedTwitter #NephTwitter

unmfund.org/fund/unm-kidne…
🧵2. Your donations have directly translated into essential discoveries leading to improved human health. We appreciate the genuine relationship with our supporters and research participants.

#gadolinium #patientsafety #NephTwitter
🧵3. Financial support assisted with several publications throughout 2022, benchtop experiments, and the continuation of our clinical trials. Also, in 2022 we discovered that gadolinium-rich nanoparticles form in the human kidney from routine diagnostic care.

#MedTwitter
🧵4. We are unaware of any other metallic nanoparticle that aggregates incidentally in humans. These intracellular nanoparticles undoubtedly impact cellular physiology and are highly suspect as the first step in causing symptoms associated with #gadolinium exposure.
🧵5. With your support, we plan on continuing objective experiments concerning magnetic resonance imaging contrast agent safety. We want to keep you, our community partner, apprised and involved in this journey.

#nanotoxicology #metals #medicine #ecotoxicology
🧵6. Contributions will continue to be directed to scientific research, publishing these discoveries, and using these data in applications for more grant funding.

#MRISafety #MultiSymptom #Disease
🧵7. Successful completion of our studies will provide novel insight into:
1) central mechanisms by which heavy metals trigger systemic diseases and
2) rational therapeutic targets for prevention and treatment.

We are indebted to you!

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More from @Wagner_Nephro

May 5, 2020
We advise clinicians to do the following to improve patient safety:

1) Limit the volume of administered gadolinium-based contrast agents when used
kidney360.asnjournals.org/content/early/…

#gadolinium
☢️#radiology
#nephrology
🏥#patientsafety
#risk #management
#medical #ethics
#FOAMed
2) increase patient education, incorporate informed consent and shared decision making when GBCA administration occurs;

kidney360.asnjournals.org/content/early/…

#gadolinium
☢️#radiology
#nephrology
🏥#patientsafety
#risk #management
#medical #ethics
#FOAMed
3) maintain careful institutional records of administered agents along with the volume and frequency,

kidney360.asnjournals.org/content/early/…

#gadolinium
☢️#radiology
#nephrology
🏥#patientsafety
#risk #management
#medical #ethics
#FOAMed
Read 4 tweets
Jan 23, 2020
Now: “Dialyzing the Undocumented: Driving Policy with Data”
by Dr. Lilia Cervantes, M.D.
Denver Health Medical Center and the University of Colorado Anschutz Medical Group
@Cervantes_Lily1 University of New Mexico Health Science Center Department of Medicine Grand Rounds
“Patients sometimes consumed foods [knowingly] high in potassium,” in order to gain admission — @Cervantes_Lily1 University of New Mexico Health Science Center Department of Medicine Grand Rounds
“So, you are asking me to keep a patient sicker so you can make more money? I am sorry, that is not why I became a physician,” @Cervantes_Lily1 University of New Mexico Health Science Center Department of Medicine Grand Rounds
Read 16 tweets
Oct 5, 2019
“Around 2012 or 2013, researchers identified evidence that gadolinium retention was connected to illness in patients with normal kidney function.” scholar.google.com/scholar_case?c…
“In September 2017, after the FDA voted to add concerns about gadolinium retention on warning labels, [gadolinium-based contrast agent] manufacturers, including Defendants, issued a new joint warning to patients with normal kidney function.” scholar.google.com/scholar_case?c…
“The warning [RE: #gadolinium retention] also directed physicians to advise patients of these concerns.”

Consent: valued in the United States since the Nuremberg trials of 1947 🇺🇸 scholar.google.com/scholar_case?c…

☢️#radiology
🥼#nephrology
🏥#publichealth ⚠️#patientsafety
💉#MRIdye
Read 4 tweets
Jun 9, 2019
“[T]he American College of Radiology have categorized the various ligands into different safety classes ... despite being grounded in purely observational data,” physiology.org/doi/full/10.11…
#gadolinium ☠️ #patientsafety #radiology #Nephrology
The “American College of Radiology] Committee on Drugs and Contrast Media considers the risk of [‘nephrogenic’ systemic fibrosis] among patients exposed to standard or lower than standard doses of group II [gadolinium-based contrast agents] is ... possibly nonexistent...”
The American College of Radiology, based on more opinion than evidence, guided Group II agents—such as MultiHance—as having “sufficiently low or possibly nonexistent” risk for gadolinium-induced systemic fibrosis. acr.org/Clinical-Resou…
#gadolinium ☠️ #radiology ☢️ #Nephrology
Read 4 tweets
May 13, 2019
“Gadolinium-based contrast agents: Stimulators of myeloid-induced renal fibrosis and major metabolic disruptors,“ is now in press—sciencedirect.com/science/articl…

#gadolinium
#neurology 🧠
#radiology ☢️
#patientsafety
#publichealth
#toxicology
#dermatology
#nephrology
Gadolinium-based “magnetic resonance imaging contrast agent treatment impaired renal function, induced pathologic damage, and increased kidney fibrosis,” sciencedirect.com/science/articl…

#gadolinium
#nephrology
#radiology ☢️
#patientsafety
#publichealth
#toxicology
Read 11 tweets
Apr 30, 2019
“[I]t is known that during those at least 6 weeks [after exposure to gadolinium-based contrast agent] equilibrium has not been reached and [gadolinium] can be measured for all [gadolinium-based contrast agents] in tissue,” fda.gov/downloads/Advi…

#gadolinium
🧠
☢️
“It is important to note that the exact mechanism and in particular other co-factors that are likely needed to trigger [‘nephrogenic’ systemic fibrosis] are still unknown,” fda.gov/downloads/Advi…

#gadolinium
#neurology 🧠
#radiology ☢️
#patientsafety
#publichealth
“[T]he levels of gadolinium in the body considered normal in the absence of any [gadolinium-based contrast agent] exposure is, for practical purposes, zero,” fda.gov/downloads/Advi…

#gadolinium
#neurology 🧠
#radiology ☢️
#patientsafety
#publichealth
#toxicology
Read 4 tweets

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