Mitochondrial dysfunction is the term most frequently used to describe impairment in mitochondrial function. 🧵
The diseases and illnesses that have been associated with mitochondrial dysfunction are widespread, and the list includes almost all of the psychiatric disorders.
It also includes the metabolic and neurological disorders such as obesity, diabetes, cardiovascular disease, Alzheimer’s disease, epilepsy, many cancers and Parkinson’s disease, and more…
If all this evidence has existed for a while, why hasn’t anyone else suggested that mitochondrial dysfunction is the common pathway to metabolic or mental disorders?
Well . . . they have! To most people reading this, all of this may seem like new information. However, #BrainEnergy is not the first theory to assert the importance of mitochondria in human health and disease.
What these researchers failed to consider is how many other roles mitochondria play in cells apart from the production of energy.
They also failed to recognize just how many different factors affect the function and health of mitochondria. When mitochondria don’t function properly, neither does the brain.
When brain metabolism is not properly controlled, the brain doesn’t work properly. Symptoms can be highly variable, but mitochondrial dysfunction is both necessary and sufficient to explain all the symptoms of mental illness.
Defining what "dysfunction" means is difficult and has been a challenge to scientists; it can mean very different things in different research studies. 🧵
The same can be said for cars. If a car is “dysfunctional,” what does that mean? It could mean that the engine sputters when traveling down the highway.
It could mean that a tire is flat, and the car can’t move along the road as easily. It could mean that the lights and the turn signals aren’t working.
In your body, energy needs to be produced in the right amount, in the right place, at the right time, and it goes through an unimaginably fast recycling process that involves #mitochondria.
The #mitochondria that aren’t moving appear to stay in places where things are always happening—either near factories where proteins are made (ribosomes) or synapses where there is a lot of activity, which is a very important fact relevant to how the #brain functions.
Researchers looking at #braincells under #microscopes have known for decades how to identify where the synapses are—they look for the mitochondria.