WesElyMD Profile picture
Jan 5 9 tweets 5 min read
1/🧵 Fake Science is BIG Business💰💰

What’s a “paper mill?

📍>500 “fake science” papers are being retracted
📍“Paper Mills” create made-up papers, trick peer review
📍People pay for authorship to boost academic credentials

Let me explain

bit.ly/3WXnhDx
2/ In this example👇…

manipulated peer-review was proven & >500 papers are being pulled! 🤯

H/T Neuroscientist @Schrag_Matthew explained:

“It's a bad look for Wiley!”

Investigators found irregular reviewer activity & ‘bad actors’ across publications

bit.ly/3WXnhDx
3/ As a Physician-Scientist at the bedside, it’s maddening & saddening to see people succumb to #misinformation

And then make choices that allow them to fall into severe life-threatening COVID and land in my ICU.

nyti.ms/3VHospA
4/ How bad is COVID-Misinformation??

The @nytimes op-ed above states that in 1 month‼️ there were over half-million conspiracy theory tweets w 580,000 retweets & a surge of toxic material spawned by a film calling COVID vaccines “the greatest orchestrated die-off” in 🌍 history.
5/ Paper mills create huge numbers of papers using mixed datasets & fake data.

They change phrases to avoid plagiarism detection like using a tortured phrase like “counterfeit consciousness” instead of “artificial intelligence”

CRAZY
bit.ly/3Z3qymL
6/ The fraud producers then sell off authorship for thousands of 💵

To ensure publication, they rig fake “suggested” journal reviewers they control

As an physician for 30 years diligently producing every data point & paper, it’s hard to imagine anyone sinking this low.

But…
7/ I recently published 🧵👇on scientific misconduct

Friends, we are subject to so much UNTRUTH - be wary of where you get your information.

Especially in COVID times, we must be super careful not to be duped & put in harm’s way.
8/ Sleuths like @MicrobiomDigest are devoting immense energy & talent into this fight toward research integrity.

Thank goodness!

They find 1,000s of articles potentially coming from paper mills.
 
go.nature.com/3Ck8lrs
9/fin
“It is embarrassing that so many papers are fake. Kudos when they admit they have been fooled.”

✔️Ultimately this is about #Ego & #Money
✔️It’s mainly (but not always) from lower tier journals
✔️Stay sharp in your reading

go.nature.com/3GbPWxU

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More from @WesElyMD

Jan 3
1/🧵 Our cell’s genes are rewired in MILD COVID 🧬
 
Stunning data in @Nature
 
White Cells (monocytes) switch gene expression from an established innate immune profile to a pro-clotting signature in COVID.
 
We’re immunocompromised.

Let’s unpack this…
 
go.nature.com/3GeDygW
2/ These data explain how the COVID virus places our bodies at risk for macro (large) blood clots in acute dz (which we see often), brain disease due to down-stream micro-clotting, and possibly later cardiovascular dz.
 
What did these London investigators find?
3/ Taking blood from 2 UK SARS CoV2 studies…

📍They compared COVID🩸(N=62 mild/mod dz) to normal controls
📍Then conducted genetic, metabolic & functional assays
👀 Look how different gene expression was (color difference) in COVID vs. HC (healthy control) pts
 
What’s it mean?
Read 8 tweets
Dec 29, 2022
1/🧵Diabetes is part of Long COVID & a diabetes drug reduces Long COVID⁉️

📌 Studies of MILLIONS show COVID ⬆️ risk of new onset Diabetes by…
📌60%!! 🤯
📌 #Diabetes 1 & 2 are solidly documented components of #LongCOVID

👇 I unpack data & what this means & why should you care?
2/ First, this is fascinating & scary. Check it…

✔️COVID is vascular disease
✔️Diabetes is a vascular disease
✔️COVID causes a chronic immune disorder
✔️Diabetes is a chronic immune disorder.
✔️A diabetes drug with immune mechanisms may help both in unrelated ways
3/ This meta-analysis of 9 studies of ~40m people found 50% increased risk of DM type 1 (insulin dependent) & 70% higher risk of DM type 2 across age groups & sex - plus way more risk than general upper respiratory infections.
 
bit.ly/3G0j4bC
Read 9 tweets
Dec 27, 2022
1/🧵Can a Diabetes drug prevent Long COVID?
 
Most solid data yet of a medication preventing #LongCOVID from quadruple blinded, non-pharma sponsored COVID-OUT trial N=1,125.

A 42% relative ⬇️ in clinician diagnosed LC was seen (10.6% down to 6.3%).
 
bit.ly/3jvvKj4
2/ Metformin’s success (1 LC prevented for every 23 pts treated) could save millions from suffering.

<$1 per course = very cost effective.
 
Too good to be true?  Maybe but very solid science.

Let me unpack a bit more…

bit.ly/3jvvKj4
3/ This trial had 6 groups of patients because 3 meds (metformin/fluvoxamine/ivermectin) were randomized vs. placebo.
 
The other drugs showed no benefit toward Long COVID reduction.
 
Metformin also looked good for Acute COVID.
Read 9 tweets
Dec 13, 2022
1/🧵Our speed in understanding Long COVID is accelerating‼️
 
Here I cover a smorgasbord of recent COVID data on…
📍Brain Aging
📍Genetics
📍Epidemiology
📍PEM
📍Self-Protection
 
Knowledge is Power.

We are all at risk of losing Brain Power from #LongCOVID.

Let’s learn…
2/ COVID ages our brains 😫
 
Cognitive decline is part of growing old, but this is scary.
 
Hot new data w age-matched uninfected control ICU patients show how COVID is associated w Molecular Signatures of an Aging Brain.
 
See Fig 2 a/b/c BELOW
 
go.nature.com/3UHvyKh
3/ Genetics

This study included normal controls. Gene expression changes occur during acute COVID19 in hospital that are associated w subsequent LongCOVID.

This was especially seen in antibody producing Plasma Cells, which explained symptom clusters.
 
go.nature.com/3FMcois
Read 21 tweets
Dec 12, 2022
1/🧵 Next Generation COVID Vaccines:

📌BF.7 & BQ1.1 have ⬆️ viral evasiveness
📌New variants pop up every 3-4 mos
📌All made worse by vaxx hesitancy & misinformation

We need a vaccine w longer protection & greater scope

But how?

bit.ly/3Bsf3v4
2/ New Vaccine Targets❓
 
🔹S protein viral sequences that are immutable, immunogenic & accessible to neutralizing Abs
🔹SARS viral membrane, envelope or nucleocapsid proteins & structurally hidden epitopes
🔹Vaccines based on T-cell receptor constructs

go.nature.com/3YaEGKt
3/fin
What would define Vaccine success?

✔️75% Protection >1 Year
✔️Not just help w death & hospitalizations
✔️Protect vs symptomatic disease
✔️Less viral transmission
✔️Fewer adverse events like myocarditis

TO DO:
Remain hopeful
Puh-leaze GET #BOOSTED

bit.ly/3hh5l7S
Read 4 tweets
Dec 9, 2022
1/🧵 Grasping for help in LC

📍as a #LongCovid patient you admitted on embarking to Turkey for pheresis that
📍this Tx was an UN-established long shot
📍but your life w this syndrome had devolved
📍as a scientist you now found yourself willing
📍while others conduct trials
2/ I see your choices in seeking therapy for #LongCOVID as brave & honest w cautious expectations cognitively & physically.

Most importantly, you’re demonstrating hope & a desire never to give up.

Knowing you, @pamelarbishop, and calling you friend is a gift beyond measure.
3/ For anyone who chides a highly intelligent person for pursuing alternative approaches to solving health problems #medicine scoffs at, seek empathy & read these truth-telling books 📚

@DouthatNYT @meghanor are my teachers…

#LongLyme #MECFS #LongCovid #Fibromyalgia
Read 4 tweets

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