Thread by @nick_krontiris

The findings of this one suggest that a high adherence to a diet that is rich in protein and unsaturated fatty acids may have beneficial long-term effects on liver fat and lipid metabolism in older subjects.

- An increased intake of protein, total fat, MUFA, PUFA and fiber as well as a decreased consumption of SFAs was achieved in the intervention group.

- Adjusted for baseline intrahepatic lipids, age, sex and BMI change, a reduction of intrahepatic lipids by 33.3% was seen in the intervention group, but the median reduction was not statistically significantly compared to the control group.

- A post-hoc analysis comparing intrahepatic lipids reduction of participants in the intervention group who were adherent to dietary recommendations with adherent participants in the control group was conducted.

- Thereby, a substantially stronger improvement of intrahepatic lipids was detected in the adherent intervention group subjects compared to the adherent control group subjects, adjusted for baseline intrahepatic lipids, age, sex and BMI change.

- In subjects who underwent proton magnetic resonance spectroscopy at baseline and after 12 months, there was a stronger reduction of total cholesterol, LDL-c and HDL-c within the intereventoion group compared to controls.

- In contrast, improvement of HOMA-IR and TG was similar in both groups after 12 months.

- Levels of liver enzymes did not change significantly in either groups.

- Note that the dietary pattern of the intervention group focused on a high proportion of unsaturated fatty acid and plant proteins (fat 35-40 % of total energy (%E) of which SFA/ MUFA/ PUFA ≤10%E/ 15-20%E/ 10-15%E, proteins 15-25%E, carbohydrates 35-45%E, ≥30g fiber per day).

Effect of unsaturated fat and protein intake on liver fat in people at risk for unhealthy aging: 1-year results of a randomized controlled trial

doi.org/10.1016/j.ajcn…

#nutrition #diet #protein #MUFAs #PUFAs #SFAs #MetabolicSyndrome