Thread by @HopeRising19

The #mrna #covidvaccines contain no added "adjuvant" such as aluminium salts. Adjuvants enhance your body's immune response when an antigen is injected. In the #Pfizer the Lipid Nano Particles LNPs themselves act as an adjuvant.

The inflammatory milieu induced by the LNPs could be partially responsible for reported side effects of mRNA-LNP-based SARS-CoV-2 vaccines in humans and are possibly contributory to their reported high potency for eliciting antibody responses (e.g. working like an adjuvant)

The cationic lipid component of the lipid carriers is often inflammatory and cytotoxic (toxic to cells)

It remains to be determined how these LNPs or their ionizable lipid component activate distinct inflammatory pathways. In theory, LNPs could activate multiple pathways or alternatively engage only one that would initiate an inflammatory cascade

We also observed upregulation of inflammasome components such Nlrp3 and enrichment of genes involved in necroptosis.

Inflammatory cell death, such as necroptosis (cell death promoting inflammation) and pyroptosis (inflammatory cell death) could cause the release of DAMPs and the further enhancement of inflammation.

The synthetic ionizable lipid in the Pfizer SARS-CoV-2 vaccine has been speculated to have approximately 20–30 days of half-life in humans (Comirnaty, 2021). If long-term presence of ionizable lipid could lead to low levels of chronic inflammation and immune exhaustion not known

Interestingly, it has been reported that the mRNA from Moderna's mRNA-LNP vaccine injected intramuscularly could be detected in very low levels in the brain, potentially indicating that the mRNA-LNP platform might cross the blood-brain barrier and reach the CNS

Overall, the robust inflammatory milieu induced by LNPs, combined with presentation of the vaccine-derived peptides/protein outside of antigen-presenting cells, might cause tissue damage and exacerbate side effects.

Because self-antigen presentation in an inflammatory environment has been linked to autoimmune disease development this merits further investigation.

Take home message LNPs are HIGHLY inflammatory and promote cell death as part of their immune stimulation and inflammatory nature.

ncbi.nlm.nih.gov/pmc/articles/P…

#LNP #informedconsent #mrna #nz #covidvaccines