1. A research was conducted on 100 healthy residents of San Francisco (mean age 39 yrs, 51% women, median BMI 24) to evaluate effects of #coffee consumption on various #Health parameters. #MedTwitter
2. Coffee consumption did not cause an increase in the rate of premature atrial contraction (PAC).
PAC can be a risk factor for future development of atrial fibrillation (AF). So, possibly, there is no increased risk of AF with coffee consumption.
3. One cup of coffee consumption did not increase the rate of premature ventricular contractions. However, there might be a possible association between consumption of more than one coffee drink per day and premature ventricular contractions.
4. Coffee consumption resulted in greater physical activity among participants (about 1000 steps more per day- 10646 steps among coffee consumers versus 9665 steps without coffee drinking). This can translate to 6-15% reduced death rate over long-term.
5. Coffee consumption resulted in 30 minutes lesser sleep (397 minutes among coffee consumers versus 432 minutes without coffee consumption). However, the impact of 30 min lesser sleep on health is not certain.
6. No apparent relationship between coffee consumption and serum glucose levels was observed.
7. Take home message
*Coffee consumption was not associated with increased rate of premature atrial complex.
Reference nejm.org/doi/full/10.10…
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Young man had undiagnosed neurological problem; skin examination revealed the diagnosis
1. 30-year old Hari presented with weakness of left foot for six months. He attributed his symptoms to a fall while cycling a week prior to the onset of symptoms. #MedTwitter#neurotwitter
2. The weakness increased over the next few weeks and his left foot was unable to clear the ground while walking. It used to "slap" the ground while walking, which Hari described as "foot drop". He had no weakness of any other part of body. He had mild numbness over left foot.
3. Hari consulted an orthopedic surgeon, who concluded no significant abnormality on ankle and knee X-rays and referred him to a neurologist. The neurologist performed nerve conduction studies and told that there is damage to a nerve in leg, most likely due to fall while cycling
Repeated short-duration numbness of one side of body: prompt management can prevent a disabling disease
1. 51-year old Mr K presented with three episodes of numbness of left side of face, arm and leg in the past 20 days. Each episode lasted only 10 minutes. #MedTwitter
2. Mr K also had feelings of tingling sensation in the affected areas. He had no weakness and could move his left arm & leg normally during those episodes. His speech also remained normal.
After 10 min, he used to have complete recovery from numbness and tingling. #neurotwitter
3. Mr K was a healthy person, with normal weight and BMI. He had no known medical illness. However, he consulted me for expert opinion.
The history was very typical of a neurological problem. Clinical examination was normal. I asked for appropriate investigations.
1. The incidence of PD has been increasing. Known risk factors such as genetic and head injury can't account for this increase in PD.
Exposure to TCE could be one of the factors causing an increase in PD.
2. TCE is a simple, six-atom molecule that can decaffeinate coffee, degrease metal parts, and dry clean clothes.
A small epidemiological study found that occupational or hobby exposure to the solvent was associated with a 500% increased risk of developing PD. #MedTwitter
3. Exposure is not confined to those who work with the chemical. TCE pollutes outdoor air & groundwater, and contaminates indoor air. The molecule, like radon, evaporates from underlying soil and groundwater and enters homes, workplaces, or schools, often undetected.
Perceived stress increases the risk of cognitive decline and dementia
1. A recent study looked at the association of perceived stress and incidence of cognitive impairment in a long-term follow up study jamanetwork.com/journals/jaman…
2. 24,448 people (median age 64 years) were followed up for >15 years. Elevated levels of perceived stress (dichotomized as low stress vs elevated stress) was associated with 1.37 times higher odds of poor cognition.
3. The association of the change in the Perceived Stress Scale score with incident cognitive impairment was significant in both the unadjusted model (OR, 1.62) and after adjustment for sociodemographic variables, cardiovascular risk factors, and depression (AOR, 1.39). #dementia
1. Dr S was a very sincere pediatrician. She would spend quality time to counsel parents and clear all their doubts. She would attend to every case referred to her in emergency room (ER) and spend at least an hour per patient.
2. Dr S had a beautiful handwriting and her case notes were detailed. For a child with viral fever too, she would write two page notes and counsel parents for one hour (even if it was past midnight). Her work was admired by parents (of sick children) as well as colleagues.
3. Within 3 months of joining the hospital, Dr S became very popular and became busy in OPD from 8 AM to 7 PM. In addition, she got calls from ER almost on daily basis and spent 3-4 hours every night attending to emergency patients. This continued for a year or so.
Drinking hot tea could increase the risk of esophageal cancer
1. Drinking tea is known to lower the risk of cancers, however, if tea is consumed hot, the risk of esophagus (food pipe) cancer can increase. #MedTwitter#Cancer#tea doi.org/10.3389%2Ffnut…
2. The overall results of the meta-analysis showed that people who drank hot tea had 77% higher risk of esophageal cancer than those who do not drink hot tea.
3. Green tea is rich in polyphenols, which have been extensively studied as a cancer chemo-preventive agent.
Epigallocatechin gallate (EGCG), the most abundant and active compound in tea, was reported to block cancer progression.