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The mechanisms involved in the anti-inflammatory properties of the #KetogenicDiet remain largely understudied. But we know they are there, and we know they are based at least somewhat on brain immunology. Here is a bit of what we do know. 🧵(1/5)
"glucose metabolism within macrophages and microglia may play a role in KD’s anti-inflammatory effects via regulation of the pro-inflammatory transcriptional activity of the transcription factor Nuclear Factor Kappa B (NFKB). (2/5)
In addition, BHB (a ketone body) is able to mitigate activation-related microglial changes, such as microglial ramification. (3/5)
This effect was observed in two neuroinflammatory models: lipopolysaccharide (LPS) administration and chronic unpredictable stress (CUS), suggesting that BHB could be a microglia stabilizer" (4/5)
doi.org/10.1016/j.pnpb… (5/5)
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