Pankti Mehta Profile picture
Apr 21 10 tweets 5 min read Twitter logo Read on Twitter
😣Patient: "All my joints are painful & swollen!"😣

👩‍⚕️But when you examine the patient, you don't find any joint swelling

How to approach this scenario? 🤷

#MedTwitter #RheumTwitter #MedEd 🧵🧵🧵

(1/10) Image
Now there are two possibilities

1️⃣ There was a joint swelling which is no longer there

OR

2️⃣ There was no joint swelling to begin with

(2/10)
Let's start with the first one– there was indeed joint swelling which is no longer there

That means we are dealing with

☝️ An episodic inflammatory disease
✌️ Drug modified disease

(3/10)
☝️Episodic inflammatory diseases

💭 Of

🔹#Gout
🔹CPPD
🔹Palindromic #rheumatoid arthritis
🔹Autoinflammatory syndromes
🔹Spondyloarthritis (especially reactive)

(4/10)
✌️ Drug-modified disease

Any inflammatory arthritis can be modified by the use of

🔹Steorids 👿
🔹DMARDs💊
🔹Complementary & alternative drugs 👿👿👿! (Very important)

So take that history well and check all records !

(5/10)
Now, let's move to scenario no.
2️⃣ There was no joint swelling to begin with

This raises 2 questions

☝️are we dealing with #arthritis?
✌️or is it something else?

(6/10)
☝️ So, what kinds of arthritis may not have joint swelling?

Simple- The ones that are non inflammatory!

💭 of

Osteoarthritis

(7/10)
✌️is it even arthritis or something else?

Confirm if the pain is restricted to the joints or not?

Regional/diffuse pain could be related to

🔹Fibromyalgia
🔹Hypermobility disorders
🔹Myalgia
🔹Bone pains
🔹Osteomalacia
🔹Neurologic pain
🔹Soft tissue rheumatism

(8/10)
Also, some diseases may only have polyarthralgia

🔹Lupus
🔹Sjogren
🔹Post Viral syndromes
🔹Hypothyroidism

(9/10)
In summary,

✅Joint pain without ❎swelling

💭 of
🔹Episodic #arthritis
🔹Drug modified arthritis
🔹Non inflammatory arthritis
🔹Regional/widespread #pain syndromes
🔹Systemic diseases with polyarthralgia!

(10/10)

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More from @PanktiMehta24

Apr 18
Rheumatoid factor

One of the most used & abused tests in #rheumatology

Let's learn a bit about its origin & utility!

#MedEd #MedTwitter #RheumTwitter

(1/15) Image
1️⃣ what is RF actually?🤷‍♀️

They are antibodies directed against the Fc fragment of IgG antibody

(2/15) Image
2️⃣ How & when was it first discovered?📆

1st described by Waaler in 1940, a factor present in 🚶‍♂️serum (in patients with RA & other diseases) that agglutinates 🐑 RBCs when sensitised with sub agglutinating doses of anti-🐑-RBC 🐰 immunoglobulin
onlinelibrary.wiley.com/doi/10.1111/j.…

(3/15)
Read 15 tweets
Jan 18
It's 🥶 & we're coming across many cases of peripheral ischemia/gangrene

🔢The semiology of seizures is what we are all taught, but gangrene is another condition where history is the king 👑

🔁It's essentially a demand≠supply mismatch

#MedEd #MedTwitter #RheumTwitter
The 📝 goes on & so that we can save ⏳ & 💰 on the tests, I like to broadly divide the pathology into:

1️⃣Luminal: atherothrombosis, thrombosis (APLA, DIC), cryofibrinogenemia

2️⃣Vessel wall: vasculitis (ANCA, PAN, SLE),vasculopathy (scleroderma spectrum)

3️⃣External compression
Q1️⃣: How was the onset?

🐌Insidious onset, gradual progression is the most common

➡️peripheral vascular disease

➡️most vasculitides

➡️vasculopathy

#MedEd #MedTwitter
Read 12 tweets
Nov 23, 2022
Learning mycobacterial rheumatism from the best @anupamwakhlu !!

#IRACON22
@IndianRheum
#Hansen's disease

✊ Arthritis in 1-78%🙀🙀🙀

Cause?

🧪Reactionary
🔥Direct inflammation
🧠neuropathic joints

#MedTwitter Image
😵confusing conundrums😵

Hansen's disease may present like

👉Rheumatoid arthritis
👉Carpal Tunnel Syndrome
👉Reactive Arthritis
👉Relapsing Polychondritis (YES!)
👉Sarcoidosis
👉Vasculitis (Lucio phenomenon)
Read 6 tweets
Nov 23, 2022
Discussing problems unique to our region 🌍

🔘Kick-starting the South Asian Rheumatology Symposium with Prof. Syed Atiqul Haq joining us in spirit !

Vaccination in ##Rheumatology

#IRACON22 #vaccine
#RheumTwitter

@IndianRheum
Pneumococcal 'prime and boost'

🕜PCV13⏩ 8 ⏩ weeks PSV23

🕜PSV23⏩1 year ⏩PCV13

🔁Repeat PSV23 at 5 years and once after 65 years!
👉 Recombinant zoster vaccine (shingrix)

👌immunity

🚫need for past h/o of VZV

2 doses:
first dose 2 weeks prior to immunosuppressant initiation
2nd dose 3 months after end of intensive immunosuppression/ drug holiday

👉Zostavax- more than 50 years if previous VZV exposure
Read 6 tweets
Nov 18, 2022
Autoinflammatory syndromes by Dr Dan Kastner at #ACR22 !

1️⃣FMF🏖️

🧬AR, pyrin mutation, evolutionary resistance to Y pestis

🌡️Fever 1-3 days
😣Peritonitis (severe)
🫁Pleurisy unilateral
✊Mono or oligoarthritis

2%-->Amyloidosis

⚕️ colchicine, anti IL1 💉

#MedTwitter #MedEd
2️⃣TRAPS

No ethnic predisposition

🧬AD, TNGRSF1A- p55

🌡️Fever 4-6 weeks
😣Serositis
♨️Migratory rash proximal -->distal
💪fasciitis
👁️ conjunctivitis, periorbital edema

Amyloidosis occasionally

❌response to colchicine
⚕️Steorids ✅ anti IL1✅
3️⃣HIDS/MKD

Northern europeans

🌡️3-7 days
😣 Serositis
🦵✊Arthritis
♨️Diffuse MP rash
Cervical adenopathy
Aphthous ulcers

⚕️Canakinumab
Read 5 tweets
Nov 5, 2022
The prevalence of #rheumatoidarthritis 🌍 ~1%

🙀 So ~14 million suffer from RA!

So we 👩‍⚕️ have to deal with special situations while managing this fairly common disease!

#MedTwitter #MedEd #rheumatology #RheumTwitter

@MedTweetorials @nihardesai7

(1/9)
Let's begin with one of the most beautiful miracles of life ☺️

#pregnancy in #rheumatoidarthritis

(2/9)
🤔Is it safe to conceive for a patient with RA? 🤰

👉Overall it is safe ☑️☑️☑️

👉But a mild risk of hypertensive disorders, IUGR and need for caesarian section +!

(3/9)
Read 9 tweets

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