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Jun 15 9 tweets 4 min read Twitter logo Read on Twitter
The findings of this one in mice suggest that dietary nitrate is capable of preserving mitochondrial bioenergetics during skeletal muscle disuse, and maintain mitochondrial-specific function during short-term (but not long-term) limb immobilization. Image
- Skeletal muscle disuse reduces muscle protein synthesis rates and induces atrophy, events associated with decreased mitochondrial respiration and increased reactive oxygen species (ROS).
- Since dietary nitrate can improve mitochondrial bioenergetics, this study examined whether nitrate supplementation attenuates disuse-induced impairments in mitochondrial function and muscle protein synthesis rates.
- Female C57Bl/6N mice were subject to single-limb casting (3 or 7 days) and consumed drinking water with or without 1 mM sodium nitrate.
- In mice subjected to single-limb immobilization, nitrate supplementation prevented the immobilization-induced decrease in mitochondrial respiration, increase in mitochondrial ROS, and reduction in mitochondrial protein content in skeletal muscle.
- These beneficial effects of nitrate occurred in response to short-term (3 days) and more prolonged (7 days) immobilization, in the absence of preventing disuse-mediated muscle atrophy or reductions in myofibrillar protein protein fractional synthesis rates.
- However, given that nitrate preserved mitochondrial protein fractional synthesis rate at 3 days of immobilization...
...these data may suggest that nitrate supplementation may represent an effective nutritional approach to maintain mitochondrial-specific function during short-term muscle disuse.
Dietary nitrate preserves mitochondrial bioenergetics and mitochondrial protein synthesis rates during short-term immobilization in mice

doi.org/10.1113/JP2847…

#nutrition #diet #supplements #supplement #exercise #GymLife #muscle #strength #lift #GetStrong #cardio #hiit

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Jun 16
This systematic review finds that overall the literature suggests that daily low-carbohydrate intake is not likely to negatively affect psychological well-being, or that this type of diet is worse than any other in this respect. Image
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Jun 15
Here, compared with men at the lowest end of the normal BMI spectrum, increased risk for an early acute coronary event was detectable already within the normal range of BMI at the age of 18 years, increasing to >5‐fold in the highest weight category at the age of 40 years. Image
- Coronary heart disease remains the dominant cause of death worldwide.
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Jun 15
This one found that among patients with newly diagnosed diabetes, a reduction in exercise frequency was related to increases in the risk of pneumonia and upper respiratory tract infection in Korean adults. Image
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Jun 15
Here, a triple agonist that interacts with GLP-1, neuropeptide Y1&Y2 receptors, regulated insulin secretion in rat and human pancreatic islets, promoted insulin-independent Y1-R-mediated glucose uptake in rat muscle tissue ex vivo and reduced food intake and body weight in rats. Image
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Jun 15
This one in mice suggests that chronic inflammation, and specifically IL-6 levels, may lead to increases in frailty and physical decline due to skeletal muscle changes that are mediated by changes in mitochondrial regulation and autophagy. Image
- This study focuses on a humanized inducible IL-6 model "due to the significant homology between mouse and human IL-6 at the amino acid level".
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Jun 14
Here, despite younger age at diagnosis, lower prevalence of obesity and diabetes family history, individuals with recently diagnosed type 2 diabetes who had a low birthweight were more likely to have greater use of glucose-lowering medications and a larger burden of comorbidity. Image
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- This study examined whether a lower or higher birthweight in type 2 diabetes is associated with clinically relevant characteristics at disease onset.
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