WesElyMD Profile picture
Aug 24 6 tweets 3 min read Twitter logo Read on Twitter
1/🧵This weeks 2 important studies on Long COVID
 
📌Include ~340k COVID patients vs ~7M controls out to 2 yrs
 📌Organ dysfunction persists in 33%
 📌Levels of disability from #LongCOVID exceed those of cancer & heart disease‼️
 
Links at end of this thread
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2/ Remember that these data complement the 8 or so other studies showing similar findings, and EXTEND the information using VERY large control groups w censoring if those controls got COVID.
3/ CAVEATS:
First, these are US Military Veterans

✏️Thus, older and more white than the average #LongCOVID person
✏️They also do NOT help us with Delta and Omicron variant COVID
✏️These findings are robust and statistically sound and published by very astute and qualified investigators
✏️But they must be extended scientifically in cohorts that include a high number of younger women, people of color and lower SEC as well as newer COVID variants.
4/ DATA:
The organ dysfunction people are suffering is a broad palette of disease including the brain, heart, lungs, peripheral muscle and nerves, GI, kidneys, skin, blood flow (clots), and mental health as well.

H/T @EricTopol GroundTruths recap:
bit.ly/3qCJoF4
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5/ Prior hospitalization ⬆️ risk of death to 6 months but not beyond (both JAMA & Nature Med studies found this)

Such patients often have COMBINATION of #PICS & #LongCOVID, which is not commonly mentioned but very important

I unpack some of this in 🧵👇
6/ TAKE HOME: Believe your family, loved ones, friends when they tell you they are suffering. This is a very real disease state that is a global public health problem. As a society, we must address these physical, cognitive, and mental health problems head on and find people medical solutions and disability support.
 
Links:
Nature Med -
JAMA:

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More from @WesElyMD

Aug 17
1/🧵 COVID & Autoimmune Diseases - more data 💥

My patient w #LongCOVID has new Raynaud’s and SLE (Lupus). She’s in tons of pain and is losing her fingers.

Study: N=4M people. COVID ⬆️ risk of new autoimmune Dz & vaccine was protective

https://t.co/Y4Wr0tItEmbit.ly/45dZMuH


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2/ New Autoimmune Diseases in #LongCOVID

There are multiple studies showing this now…

Here are two helpful figures from this Lancet article.

Note the hazard ratios >2 for Anti-phospholipid Ab syndrome, pemphigoid, and multiple sclerosis.

https://t.co/wQzYso2urIbit.ly/45dZMuH

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Here is an earlier tweet on same topic…
Read 4 tweets
Jul 25
1/🧵Long COVID Brain Problems are a global disaster

📌Hiding in plain sight
📌Too often ignored by doctors
📌Read our new Lancet-RM article
📌On the intersection of #LongCOVID & #PICS
📌I’ll unpack below

Link gives 6 weeks of open access:
authors.elsevier.com/c/1hR8b7tFB1Tt…
2/ This figure we created presents scientific mechanisms of “Neuro” #LongCOVID

We show hypothesized points for interventions that we & others around the 🌍 are testing via robustly designed randomized controlled trials to get answers for those suffering this very real disease. Image
3/ People w Long Covid are losing their ability to hear, think, and communicate.

🔹Please validate them as experts of their own illness.
🔹Read about this man’s 👇struggles & see an example of our @CIBScenter & others’ virtual support groups
🔹We can create healing communities Image
Read 8 tweets
Jun 12
1/🧵Fusion of Neurons in COVID
 
🔹At 2 yrs many #LongCOVID pts still suffer 🧠
🔹We’re beginning to understand why
🔹“Fusogens” activated by viruses like COVID can create irreversible cell-to-cell damage & miscommunication

Pic = Spike infected neuron

Link in Tw 3 Image
2/ Infections like SARS-Cov-2 drive expression of viral fusogens

These cause irreversible fusion of brain cells, causing bad neuronal communication

One of several possible explanations of brain pathology in #LongCOVID

Pic= Fused neurons w Spike & ACE2 Image
3/ Two Scary “Face the Music” Quotes:

✏️ “SARS-CoV-2 infection causes neuron-neuron, neuron-glia & glia-glia fusion in mouse hippocampal cultures”

(think = memory problems)

✏️ “Fused neurons exhibit compromised neuronal activity”

bit.ly/3J7QeYV Image
Read 11 tweets
May 30
2/ The heartbreak we see has scientists working to discover answers💔

Drs. @VirusesImmunity & @PutrinoLab explore hypotheses

📍viral persistence
📍vital reactivation
📍autoimmunity
📍inflammation

Testing antivirals, immune modulators, blood thinners. bit.ly/45E1F4v Image
3/ Data from 223 unvaxxed Mild/Mod COVID survivors

✔️ Show abnormal MRI 🧠 white matter inflammation at 9 mo vs matched controls
✔️Prolonged cellular changes occur & we don’t yet know the significance
✔️Clinical outcomes vary strikingly across studies

bit.ly/43f0vL2 ImageImage
4/ Brain inflammation in other types of #Dementia

🔸Is often present YEARS before memory & executive dysfunction deficits appear
🔸Don’t be complacent or assume #LongCOVID is safe for peoples’ brains
🔸It’s precarious!
🔸 I covered this haunting brain science in 🧵👇
Read 19 tweets
May 30
1/🧵 Long COVID’s “Disability Roulette”

🔺No longer a mass Death event…
🔺COVID-19 is an ongoing mass #Disability event
🔺You & I might get #LongCOVID
🔺But society is yawning

This thread unpacks science, policy & hope.

No Paywall Boston Globe link:
bit.ly/3OGfSb1 Image
Friends, I have an entire 20 tweet thread 🧵 uploading here (links, PDF images, etc etc -

but it’s stuck in twitter world.

I apologize for the glitch here. Oy!
2/ The heartbreak we see has scientists working to discover answers💔

Drs. @VirusesImmunity & @PutrinoLab explore hypotheses

📍viral persistence
📍vital reactivation
📍autoimmunity
📍inflammation

Testing antivirals, immune modulators, blood thinners. bit.ly/45E1F4v Image
Read 12 tweets

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