📌Include ~340k COVID patients vs ~7M controls out to 2 yrs
📌Organ dysfunction persists in 33%
📌Levels of disability from #LongCOVID exceed those of cancer & heart disease‼️
Links at end of this thread
2/ Remember that these data complement the 8 or so other studies showing similar findings, and EXTEND the information using VERY large control groups w censoring if those controls got COVID.
✏️Thus, older and more white than the average #LongCOVID person
✏️They also do NOT help us with Delta and Omicron variant COVID
✏️These findings are robust and statistically sound and published by very astute and qualified investigators
✏️But they must be extended scientifically in cohorts that include a high number of younger women, people of color and lower SEC as well as newer COVID variants.
4/ DATA:
The organ dysfunction people are suffering is a broad palette of disease including the brain, heart, lungs, peripheral muscle and nerves, GI, kidneys, skin, blood flow (clots), and mental health as well.
6/ TAKE HOME: Believe your family, loved ones, friends when they tell you they are suffering. This is a very real disease state that is a global public health problem. As a society, we must address these physical, cognitive, and mental health problems head on and find people medical solutions and disability support.
Links:
Nature Med -
JAMA:
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2/ This figure we created presents scientific mechanisms of “Neuro” #LongCOVID
We show hypothesized points for interventions that we & others around the 🌍 are testing via robustly designed randomized controlled trials to get answers for those suffering this very real disease.
3/ People w Long Covid are losing their ability to hear, think, and communicate.
🔹Please validate them as experts of their own illness.
🔹Read about this man’s 👇struggles & see an example of our @CIBScenter & others’ virtual support groups
🔹We can create healing communities
🔹At 2 yrs many #LongCOVID pts still suffer 🧠
🔹We’re beginning to understand why
🔹“Fusogens” activated by viruses like COVID can create irreversible cell-to-cell damage & miscommunication
Pic = Spike infected neuron
Link in Tw 3
2/ Infections like SARS-Cov-2 drive expression of viral fusogens
These cause irreversible fusion of brain cells, causing bad neuronal communication
One of several possible explanations of brain pathology in #LongCOVID
🔹I don’t know what you’re going through
🔹Is every day a struggle?
🔹Greg suffers #DownSyndrome, Alz Dz, Depression, Catatonia
🔹 Yet today he said, “Sunday’s donut day, but let’s have ‘chockle’ anyway & I’ll be ok.”
3/ Data from 223 unvaxxed Mild/Mod COVID survivors
✔️ Show abnormal MRI 🧠 white matter inflammation at 9 mo vs matched controls
✔️Prolonged cellular changes occur & we don’t yet know the significance
✔️Clinical outcomes vary strikingly across studies
4/ Brain inflammation in other types of #Dementia…
🔸Is often present YEARS before memory & executive dysfunction deficits appear
🔸Don’t be complacent or assume #LongCOVID is safe for peoples’ brains
🔸It’s precarious!
🔸 I covered this haunting brain science in 🧵👇