/1
Skeletal muscle does not only have a #circadian clock in 🪰🐭 BUT also in 👨‍🦱!

Ever wondered how muscle metabolism changes over 24h?

& how about young healthy vs. older metabolically-compromised men?

Then follow this 🧵 on our new work @CellReports
sciencedirect.com/science/articl… @CellReports /2
To study skeletal muscle metabolism around the clock, we combined data from 2 of our previous human studies with 2 distinct cohorts:
young healthy vs. older metabolically-compromised men

In both cohorts, 5 m. biopsies were taken on a single day:
8AM, 1PM, 6PM, 11PM & 4AM

[1/10]

A thread on our new piece in @FASEBorg

“Circadian misalignment disturbs the skeletal muscle lipidome in healthy young men” #shiftwork

@rhhoutkooper @SchrauwenP

dx.doi.org/10.1096/fj.202… 2/10

Circadian misalignment, as seen in night-shift work, is associated with a ⤴️ risk to develop many different pathologies (see figure below), especially #obesity and type 2 #diabetes are quite common in shift-workers.

tinyurl.com/w2j7kes3

1/
A thread on a new piece from my former group “Neuromuscular Electrical Stimulation Reduces Leg #Cramps in Patients With Lumbar Degenerative Disorders: A Randomized Placebo-Controlled Trial”

@JNeuromod #openaccess

tinyurl.com/yxcknvx2 2/
The psychological and physical strain as well as the social relevance of leg cramps in patients with lumbar degenerative disorders such as lumbar spinal stenosis (LSS) and disc herniation (LDH) are underestimated.