Discover and read the best of Twitter Threads about #HOCM

Most recents (2)

Very interesting results from Phase 3 #EXPLORER-HCM clinical trial: #mavacamten vs placebo for symptomatic #HOCM at #ESCCongress2020 . A new tool is given consideration for patients with obstructive HCM. The authors have to be congratulated. Excellent presentation by I. Olivotto
Is this the beginning of a dream in the treatment of HCM? Will it challenge and replace invasive septal reduction therapies by achieving sustained resolution of obstruction, complete symptom relief, neutralize risk of SCD without side effects? Let's deep into the study
The primary endpoint involved NYHA and VO2 consumption. The definition of responders requires minimal changes in objective exercise capacity and a drop of only one class. Despite this, only 20% of treated patients fulfilled it at 30 weeks
Read 12 tweets
Hypertrophic Obstructive Cardiomyopathy #HOCM🚧

#Symptoms
Profound exertional dyspnea

#Imaging
▪️SAM/LVOT obstruction #whyCMR
▪️Classic #Doppler🗡#echofirst

#Hemodynamics
▪️Brockenbrough-Braunwald-Morrow sign, explained

#Treatment
▪️Alcohol🍷septal ablation #RadialFirst
Question:
Why wouldn’t more filling time⏱ prior to post PVC beat lead to less obstruction, less gradient, & ↑ arterial pressure?

After all, doesn’t ↑LV volume in #HCM ↓gradient and improve symptoms?

Cornerstone tx is hydration/💊s that ↑ diastolic filling time ...
Read 6 tweets

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