Sometimes I hear people dismiss the possible role of a persistent #pathogen (such as a herpesvirus) in the development of a chronic #disease b/c the same pathogen can be found in healthy people
2/ I see it differently 👉 While the presence/absence of a persistent pathogen in a patient with chronic symptoms matters, the real question is: what is the pathogen doing? Is its ACTIVITY different in patients vs. healthy people?
3/ More specifically, in the #patient with chronic symptoms is the pathogen expressing different #proteins/metabolites? And are these proteins/metabolites increasingly interfering with human gene expression, metabolism, and the immune response?
4/ Moreover, has the pathogen infected tissue or nerve (or gained acess to the central #nervous system) in the patient w/ chronic symptoms in a manner that is not happening in healthy individuals?
5/ Also, in the patient, are there other ongoing issues (exposure to mold, #microbiome/virome dysbiosis, depleted immunity from others #infections, structural isses etc) that faciliate the ability of the pathogen to better drive disease?
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