Discover and read the best of Twitter Threads about #proteins

Most recents (23)

🧵#Bioinformatics in #drug #discovery and development, a THREAD🧵🧵:
#Bioinformatics is playing an increasingly important role in the discovery and development of new #drugs. In this thread, we'll explore how #bioinformatics is being used to identify new targets for drug intervention and optimize drug design.
One key aspect of #bioinformatics in drug discovery is the identification of potential #drug #targets.
Read 12 tweets
Are you interested in learning about #bioinformatics and working with #genomic data? Here's a detailed #learning path to get you started:
To build a strong foundation in biology, you'll need to learn about:
The #structure and #function of #cells, including the various #organelles and their roles in the cell. This will help you understand how cells work and how they carry out essential functions such as #metabolism and #energy production.
Read 12 tweets
🧵🧵 THREAD: #Bioinformatics and #AlphaFold 🧵🧵
1. #AlphaFold is a deep learning system developed by #DeepMind, to predict the 3D #structure of #proteins from their #aminoacid sequence.
2. #AlphaFold has been applied and tested extensively in the biennial #CASP (Critical Assessment of protein Structure Prediction) experiment, and has achieved state-of-the-art performance.
Read 9 tweets
🧵#Bioinformatics applications, a THREAD🧵🧵:
One of the key areas of #bioinformatics is the application of #computational techniques to the analysis of large #datasets of biological information, such as #genomic, #proteomic, and #metabolomic data.
#Genomic data provides information about the entire genetic makeup of a #biological system, including the #sequences of all its genes and the #regulation of their e#xpression.
Read 8 tweets
Ran some experiments! #ImmuneBuilder is better than #ESMFold (@alexrives / @TomSercu), right? There are advantages of using the latter, and now a 🧵 on why getting carried away with low RMSDs is only a part of the story...(1/5)
#machinelearning #proteins
First, the metrics are RMSDs based on aligning the C/N/CA/CB atoms across the chain, then calculating the RMSD across a region. i.e. align every residue of the VH, then calculate RMSD across CDRH3, or CDRH1, etc. This is on ~35 antibodies of the ImmuneBuilder test set (2/5)
ESMFold's CDRH3 accuracies are better than what I expected. Where it's let down is on the "canonical" CDRs. It would've been nice to compare the VH-VL orientations and talk about how ImmuneBuilder doesn't generate D-amino acids, etc. (3/5)
Read 5 tweets
Let me start with #insulin. In the 1970s, insulin was extracted from the pancreas of animals. In the 1980s, @Genentech, working with Eli Lilly (@LillyPad), developed insulin using a new technology that I call #PrecisionFermentation. It wasn’t animal insulin. It was human insulin.
The mainstream would say: “health care is slow, it can’t be disrupted.”

Well, here’s the S-curve of #PrecisionFermentation human insulin. Human insulin disrupted animal insulin in about 13 years.
#PrecisionFermentation is a concept that I coined in my @rethink_x report ‘Rethinking Food and Agriculture’ with @CatherineTubb in September 2019.
Read 30 tweets
Thread on #Magnesium and why it is fundamental for our #health. #micronutrients
..many people debate the various ratios of #macronutrients like #protein, #fat, and #carbohydrates in their diet to find their optimal health. Which is great as we are #bioindividuals but most miss out on #micronutrients like #vitamins and #minerals.
The way our bodies are able to use the #macronutrients is fully dependent on how our #enzymatic pathways are influenced by various #micronutrients. One of the most important amongst is #magnesium.
Read 19 tweets
#Clienttales 1/3
A prediabetes patient complained of gassiness and bloating post meals. After working with him on his diet -symptoms relieved by 80% and yet some gassiness existed at the end of 2 months.
Now his wife who is a hypothyroid case, wanted to start her diet program
In her first session yesterday, she too complained of gassiness & extreme bloating post meals. She reached out to her doctor who suggested antacid for a month.
Ofcourse, the antacid relieved her in the last 2 days, but is antacid the solution for this?
So there was #digestion
Something more that called for in depth evaluation of her cooking methods which is the core problem.
On checking further, got to know that dals were cooked without soaking.
So to conclude - please do wash, SOAK your grains, dals and beans and then cook for adequate time
Read 4 tweets
Many thanks to the awesome ladies at @IWS_Network for the chance to share my #immigrant #womanofcolour #womaninscience👩🏽‍🔬story throughout this week as part of their Voices Without Frontiers program!…
#IWSvoices #WomenInSTEM
I was born in #Guyana 🇬🇾
➡️ Amerindian name meaning “Land of Many Waters”.
➡️small in size (<800, 000 people), rich in natural resources
➡️only English-speaking country in South America
➡️Diversity of people with amazing cultural mix @IWS_Network #VoicesIWS #WomenInSTEM ImageKaieteur Falls - world's la...Photo Source: Guyana Times
Genetically I’m Indian - ancestors brought to ‘British Guiana’ from India during colonial times to work on #sugarplantations.

Culturally I’m #Caribbean as #Guyana shares historical and cultural ties with other Anglo-Caribbean countries.

@IWS_Network #VoicesIWS #WomenInSTEM East Woman in the Anglo-Car...
Read 20 tweets
Sometimes I hear people dismiss the possible role of a persistent #pathogen (such as a herpesvirus) in the development of a chronic #disease b/c the same pathogen can be found in healthy people
2/ I see it differently 👉 While the presence/absence of a persistent pathogen in a patient with chronic symptoms matters, the real question is: what is the pathogen doing? Is its ACTIVITY different in patients vs. healthy people?
3/ More specifically, in the #patient with chronic symptoms is the pathogen expressing different #proteins/metabolites? And are these proteins/metabolites increasingly interfering with human gene expression, metabolism, and the immune response?
Read 5 tweets
Daily Bookmarks to GAVNet 12/15/2020…

#markets #performance
New gene family of antimicrobial proteins discovered in German cockroaches…

#antimicrobial #proteins #gene
Read 8 tweets
Apparently the protein was 1st published in Feb. 1998 by Wolff et al,they called it "Strabismus", a condition which “a disorder of vision due to a deviation from normal orientation of one or both eyes” and is the medical term for ‘cross-eyed’"
Another group published the same protein in September of same year (1998) and called it Van Gogh for whatever reason. A footnote was added which said "We have determined that Van Gogh is allelic to strabismus"…
Read 7 tweets
Check out our new paper by @smartinezarbas et al. about #CRISPR mediated interactions within a wastewater #microbiome in @NatureMicrobiol! Exciting collaboration between @uni_lu @TGen @IUBloomington @isbsci @KU_Leuven. Funding by @FnrLux…

A 🧵👇

In parallel with recent work of @mhe345 @NatureComms…, we explored the roles of #plasmids and #phages within a wastewater treatment plant microbial community, using longitudinal integrated #omics data 2/9
We identified 31 bacterial MAGs with complete #CRISPR-Cas systems from the 14-months data set. These MAGs served as the basis for downstream population-level analyses of #CRISPR interactions 3/9
Read 9 tweets
Excited to announce my first first-author publication (ever!) from my PhD is now online!!!! Co-first author with the amazing @Rafiqi51. Directed by @ehab_abouheif The Great @AbouheifLab. @BioMcGill @mcgillu @EvoDevoPanAm Want to know more? [A THREAD]… 1/n
Developmental biology textbooks were of no use when the #segmentationhierarchy was #shook with #hoxgenes unleashed and the #fusion of highly conserved gene regulatory networks! #2germlines and an #embryo that gives humpty dumpty a run for his money. #CamponotusFloridanus 3/n
Read 22 tweets
Daily Bookmarks to GAVNet 7/02/2020-2…

Nathaniel Cline and Nathan Tankus: Fiscal Systems, Organizational Capacity, and Crisis: A Political Balance of Payments Approach…

#crisis #payments #balance #systems #capitalism #capacity
We might finally know why the coronavirus spread is out of control again…

#coronavirus #spread
Did protests drive more Covid-19 cases? New research reveals a surprising answer…

#COVID19Cases #research #protests
Read 8 tweets
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 68 tweets
#SARSCoV2 There are several kinds of #vaccines, whereby all share the goal of generating adaptive #immunity via 1) #antibodies via B cells, and 2) T-cell receptors (#TCRs) via T cells:
1) live-attenuated, where you produce an actual #virus in an egg or cell line
2) #recombinant, where you introduce #DNA into yeast, bacteria, or cell lines — you produce pieces of the #virus #proteins, then either administer them as-is or typically by linking them to immunogenic substrates like albumin, BSA and KLH
Read 6 tweets
At least 7 teams are developing #SARSCoV2 #vaccines using a weakened / inactivated virus. Several existing vaccines are made this way, i.e. #measles & #polio #vaccine. Sinovac Biotech started to test an inactivated SARS-CoV-2 #COVID19 vaccine. #scicomm
At least 25 groups are working on viral-vector #SARSCoV2 #COVID19 #vaccines. A #virus such as #measles or #adenovirus is genetically engineered so it can produce #coronavirus #proteins in the body. These #viruses are weakened so they CANNOT cause disease.
At least 20 teams are using genetic instructions (#DNA or #RNA) for a #SARSCoV2 #coronavirus #protein that prompts an immune response. The nucleic acid is inserted into human cells, which churn out copies of the #virus protein; most encode the virus’s spike protein. #COVID19
Read 5 tweets
😮! These findings significantly expand on a central mechanism by which persistent #pathogens drive chronic disease 👉 Namely, the ability of intracellular pathogens to dysregulate host receptor actvity in a manner that alters downstream pathway signaling:… ImageImage
2/ Specifically they found that a “vast number” of intracellular pathogens can bind (or create #proteins that bind) #receptor tyrosine kinases (RTKs) on the surface of host cells 👉 This facilitates their entry into the host cell + dysregulates cell signaling in numerous ways. Image
3/ Look at the figure below, which lists dozens + dozens of human #viruses with this capacity 👉 These viruses can dysregulate RTK activity to facilitate their entry into host cells by clustering in #lipid rafts, adjusting cytoskeletal dynamics, modulating endocytosis etc etc Image
Read 4 tweets
Holobiont activity in chronic disease 👉In this analysis of #cardiovascular-disease-related proteins in human blood☝️genetics contributed most to immune-related proteins, while #microbiome contributed most to proteins tied to metabolism + intestinal…
Worth noting that the team largely assumed that the proteins identified in #blood were derived from the gut microbiome 👉 but some #proteins could have been derived from organisms in the blood itself and/or organisms persisting in #microbiome communities outside the gut
Overall takeaway 👉 “This study provides important evidence for a joint genetic and microbial effect in #cardiovascular disease and provides directions for future applications in personalized medicine”
Read 3 tweets
Team searches for prokaryotic small #proteins in #HMP dataset that are traditionally hard to detect 👉 Describe more than 4000 conserved protein families, most of which are novel (90% have no known domain, and ~1/2 are not represented in reference genomes)… ImageImageImageImage
Small #proteins identified by the team are 👉 potentially involved in crosstalk w/ the host or other #microbial cells, may be subject to horizontal #gene transfer...and may be related to defense against #phage or other bacteria (among other functions!):… Image
Also, important previous discoveries by Ami S Bhatt and @kyrpides (both authors of the small protein paper) 👉 are featured in my recent article: “My favorite 2018 #papers that impact the study of chronic inflammatory disease”☝️Check them out:… ImageImage
Read 3 tweets
Hello, I am Edna Matta. I was born in #Ibague, known as #Colombia’s #CityofMusic. A beautiful place near snow-covered volcanos (Ruiz, Santa Isabel and Tolima), large expanses of paramo forest, lakes and streams where a diverse array of animal and plant species coexist
My story starts with #powerful, #strong #women in my #family. I was the third of 4 children and my mom #firstMentor had to raise us practically alone, since my father had to work in a different city, 20h away by car
My mom is a very #strong #woman that taught me #values, to #workhard and to be #self-sufficient #StrongWomen #StrongFamily
@IWS_Network #VoicesIWS /1
Read 36 tweets

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