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Eric Orcadian
@EricOrcadian
, 13 tweets, 7 min read Read on Twitter
MC1R + KITLG / SLC24A4 (-) Eumelanin
EYCL3 B Homozygous = Negative
HERC2 B Homozygous = Negative
Intron 86 GG (-) P + OCA2 AG Polymorphism
Preservation of Phenotypes
#Anglogenics
Phenotype: ANGLO-SAXON
Profile Estimation:
mtHaplo = H1 or H3
MC1R + KITLG (-) Eumelanin
SLC24A5 (+) NCKX5 / TPCN2 A Polymorphism
HERC2 b Heterozygous = Positive
ECYL3 B Heterozygous = Positive
#Anglogenics
Phenotype: KELTIC-NORDID
Profile Estimation:
Y-Haplo: R1b
mtHaplo = H
MC1R C Polymorphism + D294H
ASIP – αMSH (+) Pheomelanin
HERC2 + EYCL3 b Homozygous = Positive
Intron 86 GG (-) P + OCA2 AG Polymorphism
#Anglogenics
Phenotype: ALPINID
Profile Estimation:
mtHaplo = K or H
MC1R + αMSH + TYRP1 (+) Eumelanin
ECYL3 B Heterozygous = Negative
HERC2 b Heterozygous = Negative
Intron 86 AA (+) P / OCA2 CT Polymorphism
#Anglogenics
Phenotype: WEST-BALTID
Profile Estimation:
mtHaplo = H1 or H3
MC1R + KITLG - TYR (-) Eumelanin
SLC24A5 (+) NCKX5 / SLC45A2 (+) MATP
TPCN2 A Polymorphism
HERC2 B Heterozygous = Negative
EYCL1 G Homozygous = Positive
#Anglogenics
Phenotype: ATLANTID
Profile Estimation:
Y-Haplo = R1 or i2
mtHaplo = H
MC1R + αMSH + TYRP1 (+) Eumelanin
ECYL3 B Homozygous = Positive
HERC2 b Homozygous = Negative
Intron 86 AA (+) P / OCA2 CT Polymorphism
#Anglogenics
Phenotype: BRUNN
Profile Estimation:
mtHaplo = K or H
MC1R T Polymorphism + R160W
ASIP – αMSH (+) Pheomelanin
HERC2 b Homozygous = Positive
ECYL3 B Heterozygous = Negative
#Anglogenics
Phenotype: HALLSTATT
Profile Estimation:
Y-Haplo = i1
mtHaplo = H1 or H3
MC1R + KITLG (-) Eumelanin
SLC24A5 (+) NCKX5 / TPCN2 A Polymorphism
HERC2 + ECYL1 b + EYCL3 b Homozygous = Positive
Intron 86 GG (-) P + OCA2 AG Polymorphism
#Anglogenics
Phenotype: BORREBY
Profile Estimation:
mtHaplo = H1 or H3
MC1R + KITLG (-) Eumelanin
SLC24A5 (+) NCKX5 / TPCN2 A Polymorphism
HERC2 b Homozygous = Positive
EYCL1 G Homozygous = Positive
#Anglogenics
Phenotype: DINARID
Profile Estimation:
mtHaplo = T or H
MC1R + POMC (+) αMSH - IRF4 (+) Eumelanin
HERC2 b Heterozygous = Negative
EYCL2 + EYCL3 B Homozygous = Positive
#Anglogenics
Phenotype: KELTIC-NORDID
Profile Estimation:
mtHaplo = J or H
MC1R T Polymorphism + R142H
ASIP – αMSH (+) Pheomelanin
HERC2 + EYCL3 b Homozygous = Positive
Intron 86 GG (-) P + OCA2 AG Polymorphism
#Anglogenics
Phenotype: NORTH-ATLANTID
Profile Estimation:
Y-Haplo = R1b
mtHaplo = H
MC1R + POMC (+) αMSH - TYRP1 (+) Eumelanin
HERC2 B Homozygous = Negative
Intron 86 GG (-) P + OCA2 AG Polymorphism
#Anglogenics
Phenotype: NORDID
Profile Estimation:
mtHaplo = H or U
MC1R + KITLG - TYR (-) Eumelanin
SLC24A5 (+) NCKX5 / SLC45A2 (+) MATP
TPCN2 A Polymorphism
HERC2 B Heterozygous = Negative
EYCL1 G Homozygous = Positive
#Anglogenics
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Eric Orcadian
@EricOrcadian
1. Director Stephanie Welch raised a $75,000 budget through a Kickstarter campaign to fund this film as a civil rights project – not a scientific inquiry. Despite the criticisms to follow, I recommend A Dangerous Idea to all as a cautionary example.. vimeo.com/290824412
2. of how social propaganda is used to cloud public understanding of inconvenient scientific realities. Many of the interviewees like Robert Reisch and Van Jones are short on scientific authority but long on moral proclamations with much of their commentary rolled into the film’s
3. narration to shepherd the audience away from undesirable thought patterns. These voices, among others, comprise a carefully selected group of persuaders pushing a central theme: The likelihood that inequality is dealt out by genetic differences is an unconscionable prospect.
Read 21 tweets
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Eric Orcadian
@EricOrcadian
In 2000 the HGP quoted an audacious statistic about the level of DNA similarity between different humans that was quickly adopted by academics, pro-egalitarian activists, and race-deniers. These groups have loudly championed this statistic with patronizing adulation ever since.
But is it true? The HGP’s findings were predicated on the assumption that all parts of human genome are identical except for SNPs (changes to single nucleotides that can regulate allelic expression in genes) which they calculated at a maximum variance of 0.1% between all humans.
Studies involving a new trend in molecular genetics called DNA copy number variations (CNVs) that challenges the stat. were first published in 2002 but have been absent from much of the subsequent social commentary and mainstream news articles.
Read 11 tweets
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Eric Orcadian
@EricOrcadian
1. Let me first say that I’m not a paleontologist or any kind of expert on Cheddar Man (CM). My interest thus far has been somewhat cursory. That said let’s start with the obvious. It isn’t possible to conduct a GWAS on a 9,000 year old skeleton. If they isolated markers from..
2. MC1R and IRF4, than they were able to produce at least partial sequences of C-16 and C-4 using this magical mystery technique. For the sake of argument, lets assume they did. The mutation that created red hair manifests itself in about 8 different alleles in MC1R.
3. The primary pigmentation locus in IRF4 is at rs12203592. The chart below is from an Australian study that shows allelic relationships to skin and hair color. Note there are no dark skin associations.
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#röstamermänskligt
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