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Audrey Odom John MD PhD Profile picture
@odomjohnlab
Nov 26, 2019 • 7 tweets • 13 min read • Read on X
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A little parasitology #MedEd inspired by d1 @CHOP_ID:

Diarrhea after contact with baby cows? Think #cryptosporidiosis! 💩+ 🐄 = #crypto

The other big exposure risk? Recreational water, especially pools and lakes 🏊‍♂️

cdc.gov/mmwr/volumes/6…

/1 Image
@CHOP_ID Calf exposure is such a big risk b/c calves are very likely to have #crypto. My favorite outbreak is this 2013 overturned cattle truck carrying 100s of calves. RR for diarrhea 3.0 in first responders who "carried calves":

cdc.gov/mmwr/preview/m…

/2
@CHOP_ID T-cell immunity is important to #crypto control - think uncontrolled HIV and cyclosporin inhibitors (tacro, CsA).

First key to management - restore immune function.

Antiparasitic treatment with nitazoxanide also helpful - but often not enough if IC

cdc.gov/parasites/cryp…
@CHOP_ID That's why we need better antiparasitics for #crypto! But the parasite couldn't even be cultured not that long ago. Huge props to superheroes @striepenlab @pennvet , David Sibley @WUSTLmed, @SaterialeLab and Chris Huston @uvermont and others for their groundbreaking work!

/4
@CHOP_ID @striepenlab @pennvet @WUSTLmed @SaterialeLab @uvermont Fun fact: #Crypto is an Apicomplexan parasite, a distant cousin of the #Plasmodium #malaria parasites. But it has lost the canonical #apicoplast characteristic of the genus!

Since #apicoplasts are important to make #isoprenoids, you might think - how does #crypto get IPP? /5
@CHOP_ID @striepenlab @pennvet @WUSTLmed @SaterialeLab @uvermont Why, from its host cell, of course! Nice work in 2013 from Kovi Bessof, @SaterialeLab, and Chris Huston found that statins (inhibitors of human #isoprenoid biosynthesis) have anticryptosporidial activity:

aac.asm.org/content/57/4/1…

/6 Image
@CHOP_ID @striepenlab @pennvet @WUSTLmed @SaterialeLab @uvermont A final note - while #crypto is a pesky infection here in the US, it remains an important cause of life-threatening diarrhea in children worldwide - and very understudied.

It's "time to tackle" #cryptosporidiosis @striepenlab nature.com/articles/50318…

/fin Image

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More from @odomjohnlab

Audrey Odom John MD PhD Profile picture
Aug 2, 2020
Oh, look at these VERY GOOD DOGS! 🐶

Covid-sniffing puppers from PennVet @pennvet @PennVetWDC, happily working hard on our pediatric SARS-CoV2-infected samples! @CHOP_ID @CHOP_Research

nbcnews.com/nightly-news/v… Image
The whole video is just adorable - look at their tails go! (And the data is looking good, too)

nbcnews.com/nightly-news/v…
More on our study:
Read 5 tweets
Audrey Odom John MD PhD Profile picture
Jul 19, 2020
Day 1 of #idsaracialequitychallenge:
@NPR Shortwave Podcast on understanding unconscious bias:
npr.org/2020/07/14/891…
Day 2 of #IDSARacialEquityChallenge. Today, I’m borrowing these great podcast recs:



@IDSAInfo @PIDSociety #dothework https://t.co/SgPhfwULci
Day 3 of #IDSARacialEquityChallenge.

With fellowship interview season coming up, time to look in the mirror and retake the Harvard Implicit Association Test. Takes <10 min, and IMHO should be required for all academic selection committees:

implicit.harvard.edu/implicit/selec…
Read 31 tweets
Audrey Odom John MD PhD Profile picture
Jun 11, 2020
So excited to share some new work @PLOSPathogens from our group – on zoonotic staphylococci!

So, how’d we get from #malaria parasites to pathogens of puppies 🐶?

🧵

journals.plos.org/plospathogens/…
We’ve been collaborating w/Cindy Dowd at GWU (@GWtweets) making new antimalarials called MEPicides = cool prodrugs that target the DXR enzyme of the MEP pathway -- an essential biosynthetic pathway that humans and other mammals just don’t have/2

see:
nature.com/articles/s4159…
Turns out, malaria parasites aren’t the only bugs with the MEP pathway. We were totally inspired by Dan Beiting @hostmicrobe @pennvet – they found that staphylococci have either the mevalonate pathway (like people) or the MEP pathway (like parasites)/3

msphere.asm.org/content/1/5/e0…
Read 8 tweets
Audrey Odom John MD PhD Profile picture
Nov 27, 2019
#IDTwitter, a clinical pearl from d2 @CHOP_ID

Retropharyngeal abscess (RPA) is increasing in incidence (data from 2000 - 2012).

How likely is MRSA? Do you need to empirically cover? /1

academic.oup.com/jpids/article/…
@CHOP_ID To guide us, fortunately we have really nice data - from our own institution (from otolaryngologist Lisa Elden @CHOP_Research)!

A consecutive case series review of 178 kids with deep space neck infections:

…s-sagepub-com.proxy.library.upenn.edu/doi/full/10.11…

/2
@CHOP_ID @CHOP_Research We consider most infections polymicrobial, even though only 6.7% actually grew >1 organism. Common bugs in kids with surgical cultures?

☑️S. aureus (MSSA and MRSA)
☑️Group A strep
☑️other resp/oral colonizers (Hflu/S. milleri)

/3
Read 5 tweets
Audrey Odom John MD PhD Profile picture
Nov 15, 2019
Let me tell you about our newest preprint – a story of heat shock and prenylation in Plasmodium falciparum!
biorxiv.org/content/10.110…

[Thread]
Most people with malaria get fever - how do malaria parasites survive that stress? /1
First of all, P. falciparum has a ton of heat shock proteins. In particular the DnaJ/Hsp40 family is very expanded – there are 49 Hsp40 family members in P. falciparum!! /2

Reviewed here: mdpi.com/2218-273X/9/7/…
We have previously found that one of these Hsp40s in Plasmodium is farnesylated – that is, modified by a 15-carbon isoprenyl group. We call it HSP40 and it is the canonical Hsp40 in malaria parasites. /3

more on the "prenylome" of malaria parasites: nature.com/articles/srep3…
Read 5 tweets
Audrey Odom John MD PhD Profile picture
Jul 18, 2018
New article on the "leaky pipeline" of #WomeninSTEM. Once female faculty get their first big grant, they tend to stay in science - yay! But...[thread]
pnas.org/content/early/…
Senior author Greenberg is quoted in @nature: "[Women] should realize that, sure, it is not easy in academia, but they are not going to have any more difficulty than men once they get their first grant.”
nature.com/articles/d4158…
Given the percentages of women in leadership positions, in named professorships, and even full professors at many institutions, this seems a surprising conclusion. Our own institution has had equal # of women medical trainees for >15 yrs - not reflected in our leaders.
Read 4 tweets

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