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A partial list of things I've still not seen adequately explained re #COVID19:
👉What causes the thrombosis?
👉Why are pts alert & not in distress w/ severe hypoxia?
👉Why the lymphopenia?
👉Why is death so rare in kids?
👉What is different about kids who get MIS-C w/ #SARSCoV2?
👉Why is proning so helpful?
👉What characteristics of the person or virus (not activity/environment) define a superspreader (eg, #SARSCoV2 VL, genetics, etc)?
👉How does #COVID19 immune response differ in pts w/ & w/o 2nd wave of sx at d8-10?
👉How long/complete is immunity?
👉Is there a metabolic link that explains severe #COVID19 in pts w/ HTN, DM, obesity?
👉Does exp to pt w/ high #SARSCoV2 VL ⬆️ risk of transmission or severe illness?
👉What pattern of immune response predicts survival/death?
👉How do antivirals improve outcomes w/o sig ⬇️ in VL?
👉What Ab titer is protective against re-infection?
👉How long does #SARSCoV2 IgG last after #COVID19? Does it matter?
👉How is the innate immune response altered in pts who receive passive immunity w/ #convalescentplasma?
👉How are all of you asleep when there are so many Qs?
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Tatiana Prowell, MD
@tmprowell
HELP! I have a family member in Orange County, CA on a vent in critical condition for #COVID19. We are urgently seeking a person who has recovered from #coronavirus infxn w/ no symptoms in past 14d & able to donate plasma asap. Irvine/Tustin or LA area. DM me w/ leads. Pls RT.
Tweet #2: Thank you SO MUCH for your kindness! I'm getting many Qs, so answering them here for efficiency. People are asking what criteria they need to meet to donate plasma & which patients with #COVID19 can get plasma & how. See here: bit.ly/2WK2NT9.
Tweet #3: Others are asking if the donor has to be where the recipient is. The answer is no unless there is time urgency to get the product to the pt. Blood products are routinely collected at blood drives & shipped where the need is, but that does introduce a delay. #COVID19
Read 9 tweets
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Tatiana Prowell, MD
@tmprowell
A thread on pro-social behavior: The Handbook of Social Psychology describes it as "a broad range of actions intended to benefit one or more people other than oneself--behaviors such as helping, comforting, sharing & cooperation." It will be key in #COVID19 #coronavirus pandemic.
2/X When something bad occurs, there are things that predict the likelihood of someone being pro-social. The "bystander effect" refers to the phenomenon that when there are many people around, individuals are often less likely to act. #COVID19 #coronavirus
3/X Things that can contribute to a lack of pro-social behavior include:
👉Diffusion of responsibility (many people present)
👉 How others are acting, especially if there is uncertainty about seriousness
👉Fear of judgment by peers
#COVID19 #coronavirus
Read 7 tweets
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Tatiana Prowell, MD
@tmprowell
Thread: I am getting tons of msgs from fellows since a few recent talks at @hopkinskimmel, @SocTransOnc Fellows Forum, etc, + Twitter. I am happy to hear from all of you, esp the many people interested in #regulatory science. But many similar Qs, so here goes w/ resources!
@hopkinskimmel @SocTransOnc The #FDA_ASCOFellowsDay is a 1d workshop for #hematology & #oncology fellows in last yr (+ lim # of next to last yr) of training. It happens 2x/yr (fall & spring) on FDA campus in MD & 1x/yr at @ASCO Annual Mtg (1/2 day on Fri am). Applications for #ASCO20 one will open soon. 2/X
@hopkinskimmel @SocTransOnc @ASCO Our next one at the FDA campus is coming up on 3/10/20 (already full). This is a screenshot w/ high-level overview of it, and here's the link where you'll find application instructions for the next one once it opens in a few wks: asco.org/training-educa… 3/X
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