Discover and read the best of Twitter Threads about #regulatory

Most recents (24)

In May 2019, Dr. @rschilsky & I co-chaired the #AAADV19 Workshop Plenary Session "Decentralized #ClinicalTrials: The Future is Now." An incredible group of panelists from academia, industry, govt, & patient #advocacy 👇discussed the rationale, challenges, & opportunities of DCTs. Image
No one knew yet that the #COVID19 #pandemic was just around the corner. In Mar 2020, FDA released a guidance on conduct of #clinicaltrials during the pandemic: fda.gov/media/136238/d…, & colleagues wrote about the impact on #OncTwitter trials: ncbi.nlm.nih.gov/pmc/articles/P…. /2
FDA has now released a draft guidance on decentralized #clinicaltrials for drugs, biological products, & devices covering #telehealth, remote assessments, consent, shipping of IP, & more: fda.gov/media/167696/d…. #MedTwitter #regulatory #drugdevelopment Image
Read 5 tweets
Monday Top Crypto News.

Everything you need to know in one short thread…
The new episode of our newsletter was released last night, which includes our take on the current #macro environment.

Read it and sign up here

londoncryptoclub.substack.com/p/connecting-t…
Signature Bank’s crypto-related deposits will be returned to customers directly, rather than being taken over by a unit of #NewYork Community #Bancorp under a deal announced Sunday.
Read 10 tweets
5 Trends in #DeFi for 2023

1/6 As we enter the new year, many are curious about the trends that will shape the #DeFi space in 2023. Here are the top 5 trends that experts predict will have an impact:

🧵A thread by @esatoshiclub
2/6 Push toward real-world assets

Real-world assets (RWA) are helping to unlock liquidity and utility by moving on-chain. @MakerDAO has invested in US Treasuries and corporate bonds and partnered with #banks. These moves could become more common in 2023
3/6 Greater stablecoin adoption

#Stablecoins, like #USDC and #DAI, are seeing continued success despite bear market conditions. #Japan is lifting its ban on foreign-issued stablecoins in 2023, which could boost adoption and reduce time and costs on international remittances.
Read 6 tweets
We are short $PVBC, a small #bank with massive crypto loan exposure. The loans are already #defaulting and share price is #rapidly declining. We think it’s a zero. Read our report: bit.ly/3OisAKH Image
$PVBC expanded its #crypto lending business to $138m within 18 months and yesterday impaired more than half of it. A 200yr old #bank went tits-up in a matter of months. Read our report: bit.ly/3OisAKH ImageImage
The $PVBC crypto lending business was led by Paul #Mansfield, who we think, is an immediate family member of the bank’s CEO David Mansfield. Read our report: bit.ly/3OisAKH ImageImage
Read 8 tweets
1/ In 2008, @US_FDA phased out #albuterol inhalers w/ ozone-depleting CFCs, including several generics.

Since then, brand-name firms have reaped $14 billion in sales on albuterol products--though the active ingredient went off #patent in 1989!

nejm.org/doi/full/10.10…

🧵👇
2/ The first #albuterol inhalers came to the market in 1981.

By the mid-1990s, inexpensive generics had become available.
3/ However, many early inhalers contained chlorofluorcarbons (CFCs).

Brand-name firms, in turn, developed more environmentally friendly #HFA and dry-powder (#DPI) #albuterol inhalers.

By their own estimates, they spent $250-400 million developing these products.
Read 16 tweets
62/bbr “The J curve of Institutional reform” (2020) egrowfoundation.org/research/growt… showed that anti-black money crusade can’t b sustained w/o Institutional reform. Corruption is a systemic problem in India(origin Bureaucratic Socialism) & can only b solved by policy+institutional reform
63/bbr This is encouraging, but more needs to be done wrt #EODB/#EORC and to translate the policy reforms announced during last 3 yrs into rules, regulations & simpler procedures for producers & exporters. m.economictimes.com/tech/technolog…
Read 17 tweets
Want to apply #deeplearning in your #regulatory #genomics analyses but overwhelmed by suite of interpretation tools? Check out ExplaiNN: interpretable and transparent neural networks for genomics with @NovakovskyG @ofornes @sara_mostafavi @WyWyWa 🧵👇
biorxiv.org/cgi/content/sh…
ExplaiNN is an adaptation of NAMs from @agarwl_ & team for genomic sequences - predictions are a linear combination of independent CNNs- each consisting of 1 conv. layer with a single filter and two FC layers. This seemingly simple approach performs similar to multi-layer CNNs1/6
It provides importance of discovered motifs by mere visualisation of weights of the output layer. No need for filter nullification or clustering of importance scores from attribution methods! ExplaiNN on ATAC-seq of mouse immune system recapitulates results of AITAC model 2/6
Read 10 tweets
Latest UPDATE on the #TFR (Travel Rule) trilogue:

EU institutions are working to finalise the #TFR text to implement the #travelrule in Europe. Please find below the latest details. The aimed-for deadline for conclusion is still the first week of June.

1/9
Key issues on table:

The provisions introduced by the @Europarl_EN requiring #verification of information for each transfer of assets, the additional requirements applied to transfers to #unhosted wallets and the #blacklist of non-compliant entities.

2/9
In the past weeks, the @EUCouncil has taken onboard the concerns from the blockchain & crypto #industry, as well as those of regulators and competent #authorities (!), that flagged the impracticality and unintended consequences these provisions would have.

3/9
Read 9 tweets
“interconnection queues” and obtaining the necessary #ImpactStudies and #permits from #each grid operator has risen from around 2.1 years for projects built in 2000-2010 to around 3.7 years for those built in 2011-2021.

#decentralizedgrid issues are key.
wired.com/story/everyone…
"researchers found that only 23% of the projects seeking grid connection between 2000 and 2016 have actually been built."

“The grid operators have limited staff to conduct these studies,”
“Maybe they haven't ramped up their workforce quickly enough.”

#Gridlock
#SkillShortages
The inability of #renewables to deliver #LargeScale solutions may NOT be due to #financing constraints. #Regulatory ones matter too.

As prices fall, the gap btw #LevelisedCostOfEnergy for #Rooftop and #SolarUtility shows, scale matters.
Alot.

#LCoE
#Investment
#DrawDownLabs
Read 3 tweets
Who else attended today's @OECD Development Co-operation Report 2021 launch event on shaping a just #DigitalTransformation?✋

Panelists expanded upon some of the report's key themes, including:

📅 Acting now!
⬆️ More #coordination
🖼️ Strong #frameworks
🧑‍🤝‍🧑 #InclusiveDevelopment
But we also heard a lot about #DigitalPublicGoods (#DPGs). Like... A LOT a lot.

So, what's the connection between #DPGs and a just, #inclusive #DigitalTransformation? Why have so many #donors, national #governments, and #tech experts alike expressed interest in #DPG solutions?
Well, they all agree that #DigitalTransformation is at a tipping point globally, with the divisions between wealthy and developing nations especially stark: 96% of the world's unconnected people live in developing countries.
Read 16 tweets
Finally, the #GoldacreReview is published! (During Parliamentary Easter holidays, mid-ping-pong on the #HealthAndCareBill...)

It's 221 pages - each PDF page is a double page spread - so this could be a lo-o-o-ong [Thread].

Here goes...
First point to note, in the Terms of Reference (p5), is that this is about "access to #NHSdata by #researchers, #commissioners, and #innovators" - i.e. #Planning and #CommercialReUse - so it is directly relevant to the operation of millions of people's #NationalDataOptOuts... Terms of reference for the review  1. How do we facilitate a
"185 wide-ranging recommendations for us to explore", says @sajidjavid (p6). Gulp! Time for some coffee...

"systems that ensure #underrepresented groups are well represented" may (partly) refer to this "landmark review", which got off to a slow start:

gov.uk/government/new… The far-reaching independent review into potential ethnic bi
Read 159 tweets
Follow along as we report live from #Links22 London. If you haven’t already, sign up for the livestream 🎥ow.ly/h6jA50HZaIH

🧵<<THREAD>>
Thanks for your patience! We're getting started in 10 minutes. #Links22
Read 16 tweets
Want to be in the top 1%?

Find the blockchain projects 99% aren't looking at.

I've done 1000s of hours of research on some of the best projects and compiled them into educational threads for other citizens to research

Here are some of my deep dives🌊

--Thread of Threads-- Image
My focus is on long-term utility blockchain/ DLT projects⛓

Not short-term meme coins

These threads will cover:

• CBDC's
• IoT + IoV
• Innovation
• Supply chain
• Data protection
• Paperless trade finance
• Cheap payment infrastructure
• Interoperability of DLT ledgers Image
Read 18 tweets
Shout out to participants in #clinicaltrials. I’m enrolled in an NIH RADx-supported trial that requires me to do #COVID19 rapid tests & PCR every other day within a time window, & then drive a pkg to a FedEx every other day by 3p. This is the 4th study I’ve joined in my life…
The studies I’ve been in have ranged from pregnancy outcomes yrs ago to #COVID19 diagnostics. I keep joining them because I believe #ScienceWillWin, but also because it’s important to be reminded what a genuine hassle it is to be in a study. /2
In the very best of circumstances, it’s an inconvenience. It ALWAYS costs participants something, whether it’s missed work, lost wages, childcare, gas for a 🚗, discomfort, or more. And it’s always one more thing in a day that may already have way too many things already (🙋🏻‍♀️). /3
Read 6 tweets
⚖️ LEGAL LOOKOUT 1: We’ve read with interest the amicus brief below filed by 24 health policy experts in the @texmed v. @HHSGov lawsuit, as we filed one, too.

Without any further digging, though, we can see off the bat that a majority of the so-called experts who signed

(1/8) ImageImageImage
onto this brief are funded by the #insurance industry.

We respect and cherish the fact that everyone party to a significant #policy debate like this one over #regulatory implementation of the #NoSurprisesAct has a voice.

But, a question to @RonaldKlain, @SecBecerra, and

(2/8)
@BrooksLaSureCMS: How can you reconcile the fact that the administration’s #regulations rely on these bankrolled academics and experts while also claiming that these regulations help #patients and our #healthcare system? This is an alternative reality.

(3/8)
Read 19 tweets
What is better in a banking career, risk management or internal audit?
@GARP_Risk
Difficult question.

Depends on where you are and what you have studied in the past?
Risk, is an emerging area, within the first world. Just visit the financial careers website to check out the jobs in Citi and elsewhere.
Read 14 tweets
India's #crypto arc in a global perspective: India lags the world by an average of 2-3 years in terms of #crypto #regulatory framework development. We are now on the 3rd Inter-Ministerial Committee on crypto. Some pts from my session at #HODLConference2021 @IAMAIForum
India's adoption of #cryptocurrency is ramping up exponentially, signalling a clear demand for these tokens in the country. India recently ranked a whopping second on Chainalysis's Global #Crypto Adoption Index @chainalysis @SEBI_India @nsitharaman @RBI @NPCI_NPCI
However, the market cap of #India #crypto projects are approx. $12 billion USD which is a small fraction of the global market cap which stands at approx. $2 trillion USD @0xPolygon @WazirXIndia @PersistenceOne @QuickswapDEX @FrontierDotXYZ @UniLend_Finance @TheMahaDAO
Read 6 tweets
#Wonk warning: a #thread on social cost of #carbon (SCC). We at @CVEPLLC expected @JoeBiden not just to reinstate higher SCC in his #dayone #climate order but also to look at incorporating #environmental #justice into it.

He did, and it matters. #OOTT /1
Background: when #federal #agencies write rules, they try to maximize net benefits or minimize net costs.

The goal is that adding up all benefits for (and costs to) society + all costs to (and benefits for) regulated parties should be > 0. /2
In this context, SCC offers a way for agencies to “monetize” societal benefits of #climate rules. Oversimplification version: Benefit = (tons of GHG avoided) * (SCC, in $/ton). There are couple of quirks, tho. /3
Read 20 tweets
For over 65 years Liv.52 has been useful to many with #liver problems. Each herbal ingredient is thoroughly tested, and heavy metal levels of Liv.52 are within permissible limits and in compliance with WHO, #AYUSH, and major regulatory agency guidelines. #HimalayaLiv52
We ensure every product is of the highest quality, for the safety and benefit of the user. Each herbal ingredient in Liv.52 is used after careful #examination as per Pharmacopoeial standards. #HimalayaLiv52
Numerous clinical studies conducted on Liv.52 over the last 65 years have proven and reinforced the efficacy and safety of the product in treating hepatic conditions. #HimalayaLiv52
Read 10 tweets
From me @CharlesTam ("the wishor") to you ("hereinafter referred to as the wishee"),

Please accept without any obligation, legal or social, implied or implicit, a #HolidayGreeting ("greeting") intended to communicate my well wishes for an environmentally-conscious, [1/11]
...socially-distanced, politically-correct, #Regulatory-compliant, #mask-protected, non-denominational celebration of the winter solstice holiday period, as practiced within the most enjoyable traditions of the religious persuasion or secular practices of your choice [2/11]
...(with respect for the religious/secular persuasions and/or traditions of others, or their choice not to practice religious or secular traditions at all) and a financially-successful, personally-fulfilling, and medically-uncomplicated recognition of the onset of the [3/11]
Read 12 tweets
Hmm. Now this is an... interesting move!

@ukhomeoffice is (unilaterally?) collapsing two Commissioner roles into one:
jobs.lawgazette.co.uk/job/699745/bio…

While HO's excuse may seem superficially plausible, one shouldn't forget both @surcamcom and the #BiometricsCommissioner have been...
...critical of @ukhomeoffice's approach and lack of adequate #safeguards and #oversight of its use of #biometric tech.

Here's the #BiometricsCommissioner admonishing @metpoliceuk for misrepresenting him on #AFR:

cbronline.com/news/biometric…

And @surcamcom has been a consistent...
...advocate for strong #independent #regulatory #oversight and against #SurveillanceCreep.

And as he - in fact both Commissioners - point out:



There are also significant practical issues, e.g. will @pritipatel resource this as one or two offices? And...
Read 4 tweets
#Demystifying #EIANotification Part III (Cont)

Today we deal with #Post EC #Monitoring.

All #Prior #Environment #Clearance (EC) letters to projects carry #Conditions that a #Project #Proponent (PP) is required to fulfill during
a) Construction phase
b) Operation phase
&
c) Post operation phase (especially in cases of mining projects)

It is extremely important that these conditions are not only available in public domain but that public is actively involved in the #Monitoring thereof.

#EIA2006 and #DraftEIA2020 provide that
In respect of Category ‘A’ project, it shall be mandatory for the #PP to make public the #EC granted for their project along with d conditions and safeguards at their cost by prominently advertising it at least in two local newspapers of d district or State where d project+
Read 15 tweets
This report is a useful and important read. #infosec #Compliance
corporatecomplianceinsights.com/2020-cyber-rep…
(Thread follows)...
Glad to see the two numbers bear out the problem I have called out over time
I wish the survey had asked how much of a decrease we would see in the 40% and 58% numbers if we got rid of compliance overheads that are not truly #regulatory #compliance obligations
Read 12 tweets

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