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RT – FINALLY out! Our new genetic study of number of children born greatly extends our 2016 Nature Genetics GWAS. Newly identified associations indicate genetic loci under present-day natural selection - here is a summary thread....biorxiv.org/content/10.110…
Extending our 2016 Nature Genetics GWAS of number of children nature.com/articles/ng.36… with a sample of around 785K, we find 43 loci associated with number of children ever born or childlessness
biorxiv.org/content/10.110…
We show that diverse biological mechanisms are related to reproductive success – both behavioural and neuro-endocrine influences biorxiv.org/content/10.110…
We joined forces this time with @mathiesoniain & compared our genome-wide significant loci associated with number of children ever born and childlessness with ancient DNA over timescales from ~2,000 to ~30,000 years before present
biorxiv.org/content/10.110…
The strongest overlap was at chr11:61.5MB with posterior probability of 96% that lead variants for ancient selection on number of children ever born represent same underlying signal biorxiv.org/content/10.110…
Integration with data from ancient DNA selection scans identifies that the FADS1/2 gene locus that has been under selection for thousands of years still remains under selection today
biorxiv.org/content/10.110…
Number of children ever born increasing alleles increased in frequency over recent generations. The derived allele increased by 0.0088% per-year between the 1938 and 1969 birth cohorts – corresponding to a selection coefficient of 1.2% (95% CIs -0.9-3.2%)
Missense alleles in ARHGAP27 are associated with increased number of children born but reduce reproductive lifespan – suggesting a trade-off between reproductive ageing and intensity biorxiv.org/content/10.110…
And for those poised to send me a long mansplaining email or tweet - yes, I have thought about how it is even possible to study the genetic transmission of having children & childlessness nature.com/articles/ng.36… or this nature.com/articles/ejhg2…
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Melinda Mills
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You asked for a simple & concrete examples of how our #COVIDー19 network #exitstrategy can move from mathematical simulation models to real life examples – see arxiv.org/abs/2004.07052 (pages 14-16) @block_per But I break it down here….
Public adherence is essential for #COVID19 social distancing. We all need an easy to understand #exitstrategy to help us gradually return to work and school. Here is our advice... arxiv.org/abs/2004.07052
We propose 3 social network strategies to #FlattenTheCurve for a #COVID19 #exitstrategy: (1) interact with similar people (homophily), (2) strengthen community contact (triadic), (3) repeated contact in closed networks (safe pods)...
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Melinda Mills
@melindacmills
UK & US 2.5-2.8 hospital beds per 1000, Germany 8, South Korea 12. Will this matter? We look at differences for general & critical care hospital beds in England and Wales #COVIDー19 #CovidUK @MarkDVerhagen David Brazel @drjenndowd @ikashnitsky osf.io/g8s96/
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Using recently published infection rates and demographic age-structure we estimated ‘hospital deserts’ where #COVIDー19 pressures will likely overwhelm the #NHSCovidHeroes #powys, #Northumberland, Rutland, #IsleofWight & #Suffolk osf.io/g8s96/
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Melinda Mills
@melindacmills
Published open access today @CommsBio our review of all ~4000 #GWAS (genetic discoveries) from @GWASCatalog nature.com/articles/s4200… 1/9
Although explosion in number of #GWAS studies, sample sizes, associations and diseases – genetic discovery still largely of European ancestry subjects – when non-European groups included more often for replication 2/9
A world map of genetic discoveries shows 72% of subjects in #GWAS studies come from just 3 countries – US, UK and Iceland 3/9
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