How a former Secretary of Defense will turn your kid into a genius problem-solver.
Thread 🧵 (1/11)
(2/11) In a 2002 news briefing about the lack of evidence linking [[Iraq]] to the supply of [[weapons of mass destruction]] to terrorist groups, former secretary of defense, [[Donald Rumsfeld]], coined a famous expression...
(3/11) Here's what he said: {{[[video]]: }}
(4/11) According to Rumsfeld there are three types of knowledge–the known knowns, the known unknowns, and the unknown unknowns. Let's forget about the known knowns, for a while and focus on the unknowns!
(5/11) The known unknowns are the stuff we know the questions to but not the answers. There are several ways in which one can go about finding answers to known questions: Google, experts, experiments, books etc. Finding answers has become quite trivial these days.
(6/11) In the olden days it was enough to just know answers. If you were in possession of the answers to common and important questions (e.g. medical, legal, financial), you were in high demand.
(7/11) But that's changing rapidly. With Google and the advent of [[artificial intelligence]], answers will become commodities. Rely on your ability to suck up and regurgitate knowledge (i.e., give answers) and you'll soon be obsolete.
(8/11) That brings us to the unknown unknowns. What would be some examples: A threat that we're not even aware of. An "unforeseeable" future development. An as of yet undiscovered disease etc. This is where we don't know the questions and, thus, can't know the answers.
(9/11) The goal in the realm of the unknown unknowns is to find the right questions. Once we've identified a question, the problem moves into the realm of the known unknowns, and the answer will be found eventually (sooner rather than later).
(10/11) The unknown unknowns is where most of our opportunities (and threats) reside. Finding the right questions is hard, even for computers, it requires creativity, out-of-the-box thinking. Asking the right questions is THE critical skill of the future.
(11/11) Most of our schools and universities still teach our kids and students how to come up with answers when they should be teaching them how to find great questions. [[@anafabrega11]]
Pitfall #1: We don‘t know how many people have been truly infected. [1/4]
Pitfall #2: We remain uncertain about the extent of protective immunity, which greatly impacts the course of the epidemic.
Pitfall #3: What’s the extent of transmission and immunity among ppl with no or minimal symptoms (and children) [2/4]
Pitfall #4: It‘s very hard to measure and model contact rates between susceptible and infectious ppl nodt only under phys distancing but also in various reopening scenarios. [3/4]
New meta-analyisis estimates: (1) proportion of truly asymptomatic #COVID19 cases and (2) proportion of #SARS_CoV_2 transmission from asymptomatic or pre-symptomatic individuals [1/3] medrxiv.org/content/10.110…
Overall, proportion of people who become infected with #SARS_CoV_2 and remain asymptomatic through the course of infection estimated to be 15% [2/3]
40-60% of #SARS_CoV_2 infections are the result of transmission from pre-symptomatic individuals. The contribution from asymptomatic individuals seems to be much smaller estimated at around 6% (but wide confidence intervals). [3/3]
@JohnsHopkinsSPH measured the prevalence of serious psychological distress in 1468 adults aged 18 years or older in Apr 2020 & compared it with an identical measure from the 2018 National Health Interview Survey (NHIS). Thread (1/6)
In April 2020, 13.6% of US adults reported symptoms of serious psychological distress, relative to 3.9% in 2018. That’s a 3.5-fold increase. (2/6)
Age: symptoms of psychological distress were highest among young adults aged 18 to 29 years. Distress decreased with increasing age in 2020. Previously, no effect of age on distress. (3/6)
Mar 17: French doctor Didier Raoult et al publish a paper suggesting that hydroxychloroquine and antibiotic azithromycin could be effective against the disease. (1/6)
Several public figures like @elonmusk jumped on the bandwagon promoting the drug based on results from basic research (not randomized trials, not even observational studies). (2/6)
And, obviously, the President also chimed in...(3/6)
Great review of neuropathogenesis and neurologic manifestations of #covid19 published in JAMA Neurology on May 29 by @SpudichLabYale (THREAD, 1/10)
How does #sarscov2 get into the CNS? ACE2 receptors are expressed in multiple regions & on multiple cels of the human brain. (2/10)
Viral invasion of the CNS could happen in one of three ways. Nr 1: via the olfactory nerve (i.e., the transcribrial route). Olfactory nerve infection could also explain the common findings of loss of smell (anosmia) and loss of taste (ageusia). (3/10)