THREAD: Are we using ACEIs & ARBs properly? A TI Tweetorial

1/6: British Columbia doctors give 4.5m scripts/year for ACE inhibitors (ACEIs) & angiotensin receptor blockers (ARBs) to control bp. Goal is to ↘️ mortality & morbidity, not simply to ↘️ bp.

#MedEd #hypertension
2/6 BEST EVIDENCE on ARBs & ACEI for #hypertension

3⃣@CochraneHTN systematic reviews:

ACEs v ARBs for htn bit.ly/34vS0hu

BP lowering efficacy of ACEIs for htn bit.ly/30YNIOX

BP lowering efficacy of ACEIs for htn https://t.co/NCl1dfCCAO

#MedEd Image
3/6 ACEIs over ARBS when considering HARMS 🤔

Both ACEIs & ARBs ↘️ blood pressure to similar extents.... BUT only ACEIs have evidence for a reduction in risk of morbidity & mortality. So they’d be your first choice 🥇

#MedEd #medsafety #ptsafety
4/6 LESS IS MORE when #prescribing 💊

Don’t use more than ½ maximum dose of ACEI. ↗️ doses do NOT meaningfully reduce blood pressure further. ½ of max dose of ACEI/ARB produces 90% & 80% of BP lowering of max dose, respectively.

#MedEd #hypertension Image
5/6 PRICES MATTER 💰💰

As drug classes, ACEIs & ARBs do not differ in blood pressure-lowering efficacy; no individual drug in either category is superior to others. The only known difference is price 🤔

#MedEd #hypertension #drugpricing Image
6/6 CHECK 💊 PRICES when #prescribing

90% of ACEI scripts in BC are for ramipril & perindopril. Cost can differ btwn equally effective 💊 in same class. In BC, 100 days perindopril 8mg = $65; equivalent ramipril 10mg = $23. Pill-splitting may save 💰, depending on price

#MedEd
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More from @Drug_Evidence

25 Sep
THREAD: 5 Things You Need to Know About PPIs

For many years, we've dissected the research on Proton Pump Inhibitors (PPIs) 🤔

This thread captures our publications on PPIs that can help you in clinical practice: ti.ubc.ca/?s=ppis

#MedEd #medsafety #DrugEvidence #GERD
2/6 PPI COSTS VARY CONSIDERABLY 💰

Even without differences in efficacy or safety between PPIs, costs can vary x 10. The cheapest in BC? Pantoprazole Mg 40mg or Rabeprazole 10mg. Most expensive: Dexlanzoprazole

More here: ti.ubc.ca/letter99

#MedEd #DrugCosts #GERD
3/6 RESPONSE IS VARIABLE

1 in 2 pts w/ acid reflux get symptom relief with a PPI (NNT~2) w/in 4-8 wks

Responders notice symptom relief w/in 1-9 days. If no relief in ~2 wks consider 🛑 PPI. Non-acid reflux doesn’t benefit from PPI

More here: ti.ubc.ca/letter99

#MedEd
Read 7 tweets
24 Jun
THREAD: Ten Commandments for patient-centred treatment 🧾

1/11 A TI Tweetorial on the “Ten Commandments’ of the New Therapeutics

Revisiting timely words of medical wisdom from the BMJ
bjgp.org/content/65/639…

#MedEd #prescribing
2/11 1st Commandment:

Thou shalt have no aim except to HELP patients, according to the GOALS they wish to achieve 👩‍⚕️
bjgp.org/content/65/639…

Shared decision-making lessons from @LessIsMoreMed: lessismoremedicine.com/hands-on

#MedEd #TreatmentGoals
3/11 2nd Commandment:

Thou shalt always seek knowledge of BENEFITS, HARMS, COSTS of treatment & share this knowledge at all times
bjgp.org/content/65/639…

Try these:
ti.ubc.ca/therapeutics-l…
@thenntgroup
medi-mouse.com
pac.bluecross.ca/pharmacycompass

#MedEd #ptsafety
Read 12 tweets
4 Jun
THREAD: Painful Evidence: Do Common treatments for pain work❓

1/10 How effective are pain drugs? 🤔

In BC 120,000 ppl take cyclobenzaprine; 160,000 take gabapentin or pregabalin. Many others take duloxetine, venlafaxine, or amitriptyline

#MedEd #TIEvidence #painmanagement Image
2/10 SIDE EFFECTS:

Most 👨🧕on gabapentin/pregabalin/duloxetine/TCAs (e.g. amitriptyline) experience some adverse side effects like sleepiness, dizziness, nausea, dry mouth or constipation

Benefits/harms here: ti.ubc.ca/letter96

#MedEd #painmanagement Image
3/10 COCHRANE pain meds EVIDENCE:

Evidence frm 8 @cochranecollab reviews should ↘️ expectations abt likelihood+size of pain relief frm gabapentin, pregabalin, duloxetine, venlafaxine, amitriptyline, nortriptyline, imipramine, desipramine

ti.ubc.ca/letter96

#painmanagement
Read 11 tweets
8 May
THREAD: High blood pressure (hypertension) – what does the best evidence say❓

1/13 A practical tweetorial for clinicians, patients and carers

#hypertension #HTNevidence #MedEd 🩺👩‍⚕️ ImageImage
2/13 What is #Hypertension?

Hypertension (high blood pressure) is a very common condition, and is associated with increased📈 risk for strokes, heart attacks and premature death 💀, so it's worth asking some 🤔👩🏾‍💻

#TIevidence #MedEd #prescribing
3/13 What about SCREENING for #hypertension?

Screening for high blood pressure might not be that helpful 😯 and early 🕗 detection of mild hypertension may not significantly impact health‐related costs in the long term nor improve health outcomes: bit.ly/35P2mcz Image
Read 8 tweets
28 Apr
THREAD: Split This! A TI tweetorial on pill splitting

1/ Split this! Pill splitting (dividing tablets into smaller doses)

Practical tips to help patients + their families make the most of their medications during the #COVID19 pandemic

#medication #pillsplitting #TIEvidence Image
2/ Split this! PILL SPLITTING can safely extend medication supplies longer, saving 💰💰 and 🚗 to the pharmacy

Most pharmacies carry pill splitters for as little as $5 😀

Consumer reports review: tinyurl.com/ycstbx2t

#medication #pillsplitting #TIEvidence
3/ Split This! #CHOLESTEROL-LOWERING DRUGS

Do you take 20mg of atorvastatin every day? Ask for 40mg tablets and split them, saving 💰💰 and 🚍 to the pharmacy

#medication #pillsplitting #TIEvidence #cholesterol Image
Read 9 tweets

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