1/
While we're all doom-scrolling through Twitter, I thought I could help provide some distraction for #medtwitter, #dermtwitter & #medstudenttwitter.

A #Derm101 #tweetorial on the #dermatology exam:

REACTION PATTERNS!

AKA: "How a dermatologist approaches a rash!"
pc:@AADskin
2/
So what exactly is a reaction pattern? It's an organizational way to think about rashes so that we can bucket them. There are FIVE main reaction patterns:

1) Papapulosquamous
2) Eczematous
3) Dermal
4) Vascular
5) Vesicobullous

Which reaction pattern was that last photo?👆
3/
It's PAPULOSQUAMOUS! The name means it's papular (raised) with scale. The prototypical rash for these is psoriasis, which is that 1st photo! Notice how in darker skin, the erythema of psoriasis is harder to see!

Here's a whole #tweetorial I made:
4/
The ddx for papulosquamous rashes can be quite long. Things like secondary syphilis (pic 1), pityriasis rubra pilaris (pic2 and 3), and lichen planus (pic 4) all fall in this category!

Notice that you need to rely on the rest of your physical exam to further differentiate!
5/
Next up, let's talk ECZEMATOUS. This one is a little tricky, because there are three stages of eczema.

1-Acute eczema, with vesicles that leak fluid (pic1).
2-Subacute, dryer, fine scale, fissure (pic2, pc: NEA).
3-Chronic, plaque with hyper-accentuated skin markings (pic3)!
6/
Remember that "ECZEMA" does not mean atopic dermatitis (AD). Whenever we say someone has eczema, all we're saying is the rash falls in the ECZEMATOUS reaction pattern!

Here's my #tweetorial on AD with more details on that distinction:
7/
Next up, DERMAL. I use this term for skin eruptions that are mainly in the dermis or subcutis. Basically not epidermal. Because of that, these rashes usually lack scale, since scale implies there's epidermal involvement.

A good example is granuloma annulare, pictured here:
8/
Another example: erythema nodosum since the inflammation's in subcutis.

Bottom line, no scale, feels deep & indurated, think "DERMAL." Think about what layer the action's in, & maybe what is filling that space (inflammation v. fibrosis v. neoplasia v. edema)!
pc: DFTbubble
9/
Okay, next up is VASCULAR. This is where the rash appears to be from blockage of vessels. Remember the skin is perfused in cones, so if you block a vessel, circles of skin necrose and you get stellate or RETIFORM edges (see pics). That's why retiform purpura is so worrisome!
10/
Remember - retiform purpura, think vasculitis (inflammation in vessel wall) or vasculopathy (blockage of vessel).

But VASCULAR things don't have to cause purpura. What is a common skin eruption you might see that is vascular in pattern, but not permanent?
11/
Livedo reticularis (pic1) is that vascular pattern you might see. It is usually physiologic, but sometimes can be pathologic.

Livedo racemosa (pic2), however, is always pathologic! It's like livedo reticularis but the net is broken! Notice how areas of the net abruptly end!
12/
Okay, VESICOBULLOUS - vesicles or bullae put you in this category.

You might have large tense bullae as those seen in bullous pemphigoid (pic1), or maybe small vesicles seen in eczema herpeticum (pic2)!

Here's my #tweetorial on this reaction pattern
13/
So how do we use this in real life?

If a rash is purely papulosquamous, then you know things in the vesicobullous category probably aren't appropriate for your differential.

But some rashes can be in MULTIPLE categories! Which 2 patterns would you pick for this rash?
14/
Here we see tiny vesicles draining fluid, so first, this is VESICOBULLOUS. You might also remember that an acute ECZEMATOUS rash also has tiny vesicles! So since this rash crosses over these two, our differential shifts to the list of eruptions that cross these 2 groups!
15/
SUMMARY:
✅Reaction patterns help us bucket rashes into one or more of 5 categories.
✅Each category, or each combination of categories can carry its own differential diagnosis.
✅The rest of the skin exam is still critical in arriving at the right diagnosis!
16/16
Thanks for joining me for this #Derm101 #tweetorial! I'm hoping it might've helped distract some of you from the craziness in the world and taught some #dermatology in the process!

In case you prefer a video format of this information, check out 👉

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More from @DrStevenTChen

22 Sep
1/
Time for another #morphology #Derm101 series #tweetorial on the skin exam. Today, we'll cover:

DISTRIBUTION

How the location a rash occupies on the body might help us with the differential diagnosis!

#FOAMEd #MedEd #medtwitter #dermtwitter #medstudenttwitter #dermatology
2/
An important point to start:
Distribution is LEAST important in the skin exam. Primary & secondary lesions, configuration & scale are all better in informing our DDx.

I tell my learners that if confused about a rash, pretend it's elsewhere on the body & see if that helps.
3/
Also - throughout this #tweetorial, I will try to display skin disease in lighter & darker skinned patients side by side. Remember in darker skin, erythema is harder to see, so I hope this highlights the point!

A question: In tweet 1, what distribution is shown in the photo:
Read 18 tweets
29 Aug
1/
OK team, #tweetorial #3 in our #Derm101 series on the #dermatology exam. Today, let's discuss:

CONFIGURATION!

How primary lesions are grouped or shaped. Read on to learn more!

#dermtwitter #medtwitter #medstudentwitter #meded #FOAMEd pc:@dermnetnz @BrwnSkinMatters
2/
Since this is the 3rd installment in the #Derm101 series, remember that if you haven't already, you might want to check out the first two #tweetorials on skin morphology.

Primary Lesion:

Secondary Lesion:
3/
I think of configuration as how the primary lesion might be shaped or grouped. So this would include rashes that are:

Annular
Polycyclic
Serpiginous
Linear
Geometric
Agminate
Herpetiform
Sporotrichoid
Target/Targetoid (kind of)

What configuration was the rash in tweet #1?
Read 20 tweets
22 Aug
1/
As promised, here's the second installment of my #Derm101 series on the #dermatology physical exam and #morphology. A #tweetorial on:

THE SECONDARY LESION!

#MedEd #FOAMEd #dermtwitter #medtwitter #medstudenttwitter pc:@dermnetnz
2/
First off, if you haven't gone through the primary lesion #tweetorial yet, it's a good idea to start there. Here's the link:

As review, these are the different primary lesions👇
3/
Secondary lesions are the changes that affect the primary lesion.

Say what? If a papule is scaly, the SCALE is the secondary lesion. If a plaque is crusty, the CRUST is the secondary lesion.

A question: What was the secondary lesion seen in the pic from the 1st tweet?
Read 16 tweets
16 Aug
1/
Let's get back to the basics. A #dermtwitter #tweetorial on:

THE PRIMARY LESION!

My plan is to make a #Derm101 series on #morphology and the #skin exam, so this will be the first in that series of #medthreads.

#MedEd #FOAMEd #medtwitter #medstudenttwitter pc:@dermnetnz Image
2/
Why are #dermatologists so obsessed with description?

Well, for us, morphology is everything. We start with the exam and take the history afterward based on the possible differential we've come up with!

So let's start simple. What was that lesion in the prior tweet?
3/
That was a PATCH of vitiligo.

PATCHES are flat lesions >1 cm wide, whereas MACULES are flat lesions <1 cm wide! Check out photo #1 of perioral vitiligo where macules are coalescing into patches!

In #2, you can see both macules and patches in these Cafe au lait lesions. ImageImage
Read 12 tweets
1 Aug
1/
METHOTREXATE!

A #tweetorial for #medtwitter, #dermtwitter, & #medstudenttwitter!

I'm no pharmacologist, so this is written from a #dermatologist's POV!

Let's start with a question that still haunts med students today:
What is the mechanism of action of methotrexate (MTX)?
2/
MTX inhibits dihydrofolate reductase in the folate pathway, which is needed for DNA/RNA ➡️ inability for cells to rapidly divide!

Given similarities in mechanism with other drugs in this pathway, caution should be used when adding MTX on top of them, especially TMP-SMX!
3/
Since MTX is an antifolate, remember that Folinic Acid (Leucovorin) is used as a "rescue" when side effects go crazy. But at the doses we use in #dermatology, I've never needed it. Plus, we give folate with MTX to prevent these effects!

Which of 👇 doses is typical in derm?
Read 18 tweets
25 Jul
LICHEN PLANUS

A #dermtwitter, #medtwitter, and #medstudenttwitter #tweetorial! PC: @dermnetnz. Let's kick off this #MedEd #FOAMEd #medthread with a question.

With LP, which one of the following body sites is most commonly involved?

1/
The correct answer is wrists! LP lesions are most commonly seen on flexor wrists, trunk, medial thighs, and shins. It very rarely involves the face.

The mnemonic for the clinical appearance of LP is to remember the "Ps."
Pruritic (!!!)
Purple
Polygonal/Planar
Papules

2/
You can also make out white and gray lacy streaks and puncta. This is called "Wickham Striae" which helps confirm the diagnosis (1).

Notably, LP also can go to the oropharynx, which can cause erosive lesions that are painful. Wickham Striae are easier to see in the mouth (2).
3/
Read 14 tweets

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