AKA: "How a dermatologist approaches a rash!"
pc:@AADskin
2/ So what exactly is a reaction pattern? It's an organizational way to think about rashes so that we can bucket them. There are FIVE main reaction patterns:
3/ It's PAPULOSQUAMOUS! The name means it's papular (raised) with scale. The prototypical rash for these is psoriasis, which is that 1st photo! Notice how in darker skin, the erythema of psoriasis is harder to see!
4/ The ddx for papulosquamous rashes can be quite long. Things like secondary syphilis (pic 1), pityriasis rubra pilaris (pic2 and 3), and lichen planus (pic 4) all fall in this category!
Notice that you need to rely on the rest of your physical exam to further differentiate!
5/ Next up, let's talk ECZEMATOUS. This one is a little tricky, because there are three stages of eczema.
1-Acute eczema, with vesicles that leak fluid (pic1).
2-Subacute, dryer, fine scale, fissure (pic2, pc: NEA).
3-Chronic, plaque with hyper-accentuated skin markings (pic3)!
6/
Remember that "ECZEMA" does not mean atopic dermatitis (AD). Whenever we say someone has eczema, all we're saying is the rash falls in the ECZEMATOUS reaction pattern!
Here's my #tweetorial on AD with more details on that distinction:
7/ Next up, DERMAL. I use this term for skin eruptions that are mainly in the dermis or subcutis. Basically not epidermal. Because of that, these rashes usually lack scale, since scale implies there's epidermal involvement.
A good example is granuloma annulare, pictured here:
8/
Another example: erythema nodosum since the inflammation's in subcutis.
Bottom line, no scale, feels deep & indurated, think "DERMAL." Think about what layer the action's in, & maybe what is filling that space (inflammation v. fibrosis v. neoplasia v. edema)!
pc: DFTbubble
9/ Okay, next up is VASCULAR. This is where the rash appears to be from blockage of vessels. Remember the skin is perfused in cones, so if you block a vessel, circles of skin necrose and you get stellate or RETIFORM edges (see pics). That's why retiform purpura is so worrisome!
10/ Remember - retiform purpura, think vasculitis (inflammation in vessel wall) or vasculopathy (blockage of vessel).
But VASCULAR things don't have to cause purpura. What is a common skin eruption you might see that is vascular in pattern, but not permanent?
11/ Livedo reticularis (pic1) is that vascular pattern you might see. It is usually physiologic, but sometimes can be pathologic.
Livedo racemosa (pic2), however, is always pathologic! It's like livedo reticularis but the net is broken! Notice how areas of the net abruptly end!
12/ Okay, VESICOBULLOUS - vesicles or bullae put you in this category.
You might have large tense bullae as those seen in bullous pemphigoid (pic1), or maybe small vesicles seen in eczema herpeticum (pic2)!
If a rash is purely papulosquamous, then you know things in the vesicobullous category probably aren't appropriate for your differential.
But some rashes can be in MULTIPLE categories! Which 2 patterns would you pick for this rash?
14/ Here we see tiny vesicles draining fluid, so first, this is VESICOBULLOUS. You might also remember that an acute ECZEMATOUS rash also has tiny vesicles! So since this rash crosses over these two, our differential shifts to the list of eruptions that cross these 2 groups!
15/ SUMMARY:
✅Reaction patterns help us bucket rashes into one or more of 5 categories.
✅Each category, or each combination of categories can carry its own differential diagnosis.
✅The rest of the skin exam is still critical in arriving at the right diagnosis!
16/16
Thanks for joining me for this #Derm101#tweetorial! I'm hoping it might've helped distract some of you from the craziness in the world and taught some #dermatology in the process!
In case you prefer a video format of this information, check out 👉
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2/
An important point to start:
Distribution is LEAST important in the skin exam. Primary & secondary lesions, configuration & scale are all better in informing our DDx.
I tell my learners that if confused about a rash, pretend it's elsewhere on the body & see if that helps.
3/
Also - throughout this #tweetorial, I will try to display skin disease in lighter & darker skinned patients side by side. Remember in darker skin, erythema is harder to see, so I hope this highlights the point!
A question: In tweet 1, what distribution is shown in the photo:
2/ Since this is the 3rd installment in the #Derm101 series, remember that if you haven't already, you might want to check out the first two #tweetorials on skin morphology.
Well, for us, morphology is everything. We start with the exam and take the history afterward based on the possible differential we've come up with!
So let's start simple. What was that lesion in the prior tweet?
3/
That was a PATCH of vitiligo.
PATCHES are flat lesions >1 cm wide, whereas MACULES are flat lesions <1 cm wide! Check out photo #1 of perioral vitiligo where macules are coalescing into patches!
In #2, you can see both macules and patches in these Cafe au lait lesions.
I'm no pharmacologist, so this is written from a #dermatologist's POV!
Let's start with a question that still haunts med students today:
What is the mechanism of action of methotrexate (MTX)?
2/ MTX inhibits dihydrofolate reductase in the folate pathway, which is needed for DNA/RNA ➡️ inability for cells to rapidly divide!
Given similarities in mechanism with other drugs in this pathway, caution should be used when adding MTX on top of them, especially TMP-SMX!
3/
Since MTX is an antifolate, remember that Folinic Acid (Leucovorin) is used as a "rescue" when side effects go crazy. But at the doses we use in #dermatology, I've never needed it. Plus, we give folate with MTX to prevent these effects!