At home antigen testing for #COVID19.

Detection of pre-symptomatic / asymptomatic cases - to a high degree of accuracy - is key.

99% specificity is a must, and ideally sensitivity of 92-93%+.

There should also be a method of logging the result in an objective manner...1/n
...elsewise individuals with positive results could disregard government instructions and go out for work / socialising regardless.

@avacta #AVCT's Affimers are an antibody mimetic - designed to overcome the limitations of monoclonal antibodies.

The evidence indicates... 2n
...that Affimer-based lateral flow tests will likely have a higher specificity than mAb-based LFTs, and possibly higher sensitivity too. Moreover, they are rapid to develop, cheaper to manufacture, and are robust (a benefit both for supply chain issues and for shelf-life).

Tech transfer of #AVCT's LFT is due to complete imminently, following which a large lay user study will commence.

As @michaelmina_lab has so well explained, regular at-home testing using antigen LFTs can be a powerful tool in suppressing the virus.

Society is in desperate...4/n
...need of such a product.

My money (literally!) is on @avacta #AVCT being one of the companies to deliver this product - to the UK market, hopefully before Christmas.

My notes on Avacta's #COVID19 LFT, and at-home testing in general (see p.8):…


• • •

Missing some Tweet in this thread? You can try to force a refresh

Keep Current with Myles McNulty

Myles McNulty Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!


Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @MylesMcNulty

9 Nov
An extraordinary day. Firstly, fabulous initial data from Pfizer's vaccine, demonstrating it's 90% effective. An immense scientific breakthrough and a boon for humanity.

From an investment perspective (the raison d'être of this account!): a day of joy and misery, equally! 1/16
Global indices absolutely rocketed - 27/100 FTSE100 Cos ended the session at 10%+. Most sectors were up, whilst precious metals miners and #COVID19-centric stocks got obliterated. The latter group included treatment and testing stocks, and at home/online entertainment/living 2/16
Personally, my PF took an almighty spanking, owing to #AVCT being my largest position by a distance, and also having recently opened a position in #SNG.

A high quality vaccine was always the key risk to #COVID19 plays, but for me, that has always been a medium term risk. 3/16
Read 16 tweets
9 Nov
Exciting development for #N4P today - Launch of Nuvec Oncology Treatment Programme.

This potentially opens up a third colossal market, after vaccine delivery x2 (injection and oral).

The really exciting thing about this Co is that its asset, Nuvec, is already developed and..1/4
...largely refined. It now need only prove consistent in-vivo success for its three target applications (oncology injection; vaccine injection; vaccine oral), and it can start out-licensing Nuvec.

And that's the core of the investment proposition: Nuvec is a platform tech. 2/4
It can be licensed out to multiple parties for multiple targets/applications. #N4P will receive upfront and milestone payments as the licensee takes the drug / vaccine (using Nuvec as the delivery platform) through the clinic.

N4P's cost base is exceptionally low; yet... 3/4
Read 4 tweets
27 Sep
#AVCT interims tomorrow.

Comprehensive updates on all work streams of the Therapeutics and Diagnostics divisions will be provided.

Naturally, the content will likely be dominated by the various #COVID19 products under development - and of those, many market participants... 1/n
...(esp. new holders) will only have eyes for the LFT.

I think it’s important to appreciate the number of short term traders - and nervous retail investors - there are in #AVCT at present.

In my view, the near-term SP movement (which I think will be strong, either way)... 2/n
...will be driven by one very simple - but critical - matter: whether #AVCT has been permitted to disclose in its interims the UK Gov’s involvement in the rollout of the LFT.

I think the majority will agree that that involvement is beyond question.

Project #Moonshot... 3/n
Read 9 tweets
24 Sep
New nano-cap position taken via placing: #BIOM @BiomePlastics.

A brief intro, with in depth notes to follow in due course:

BIOM has two operating divisions: Bioplastics (biodegradable / compostable plastics) and Stanelco RF Technologies (advanced radio frequency systems).

Interims out today, along with a placing at 120p for £1.1m gross. Assuming a successful GM, mkt cap at the current SP of 165p will be £6.1m.

Net cash post GM will be ~£1.8m, so enterprise value at 165p will be ~£4.3m.

My investment is solely based on the Bioplastics div..

..which is a rapidly growing biz operating in a rapidly expanding market that I believe will become an increasingly hot topic going forward.

I'll be posting more about the products and target markets in due course, but here's a good place to start:

Read 11 tweets
24 Sep
We now know that #AVCT's Affimers are being used in at least 5 diagnostics products for #COVID19:

- LFT (with Cytiva)
- BAMS (with Adeptrix)
- ELISA (in-house)
- Microtox BT (with #SKIN)
- Microtox PD (with SKIN)

Working prototypes for all.

And people still doubt Affimers? 1/9
For BAMS and Microtox BT and PD, #AVCT's work is largely complete. It will simply be providing a regular supply of Affimers to Adeptrix and #SKIN, and enjoy steady royalties (which, as many of us are beginning to realise, could be for much longer than initially anticipated).

This frees up mgmt's time to focus on the proprietary tests, the (all-important!) LFT and the ELISA (which I believe most are under-estimating the earnings potential of).

Whilst some might point out that none of the 5 products have yet been commercialised, I would argue... 3/9
Read 9 tweets
21 Sep
This was a fortunately timed move, but in hindsight, perhaps even more could have been taken off the table...! FTSE approaching -4% on the day.

Then again, as we all inevitably learn the hard way - hindsight is not a strategy.

Regardless, I have a healthy cash pile to...

...deploy now, with many excellent opportunities about.

#COVID19 testing stocks should of course do very well in the coming few months, with the #AZN / Oxford vaccine delayed and #Moonshot being launched.

My top picks (and the only ones I hold) remain #AVCT and #NCYT.

In my view, we won't see a market meltdown. The fear factor driven by 'The Great Unknown' is no longer present, as it was in Feb/March.

Of course, there are some sectors I won't be touching, but many industries have gotten to grips with lockdown working measures/lifestyle.

Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!