Two weeks ago we tested your ability to recognize the hippocampal subfields from histology! See the next tweet below to find out if you identified all five subfields correctly! #SubfieldWednesday
Here you go! How did you do on the quiz??

#SubfieldWednesday Five different slices of the human hippocampus, Nissl staine
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More from @hipposubfields

9 Dec
This week I thought I would share some terminology that you may or may not know!

#SubfieldWednesday (1/n)
Most of our followers probably already know how that the name "hippocampus" means "seahorse" in Greek.

#SubfieldWednesday (2/n) https://www.wbur.org/npr/505754756/the-seahorse-in-your-brai
What do you think? When it's dissected like this, I can definitely see the similarity!

#SubfieldWednesday (3/n) Hippocampus removed from the brain (left), in comparison to
Read 8 tweets
25 Nov
Hello and happy #SubfieldWednesday! Today we are going to get a bit more familiar with how the hippocampal subfields differ in their composition of different cell types, cell sizes, and layer thickness. 🍤🔬

#SubfieldWednesday (1/n)
Here are some images taken from five different hippocampal subfields (CA1, CA2, CA3, dentate gyrus, and subiculum). Can you tell which number corresponds to which subfield? 🤔

#SubfieldWednesday (2/n) Five different screenshots of histology slices of five diffe
Because a Nissl stain was applied to these slices, the cell bodies appear dark purple. This allows neuroanatomists to characterize the size, shape, and relative spacing of the cells.

#SubfieldWednesday (3/n)
Read 12 tweets
11 Nov
Happy #SubfieldWednesday! After a two-week hiatus we are returning to our quiz about the mysterious transentorhinal cortex!

This quiz even stumped some of us at @hipposubfields headquarters! We had to contact a neuroanatomist to confirm which answer is correct! (or at least "the most correct")
Braak and Braak (1985) originally described the transentorhinal cortex as a 'transition region between entorhinal cortex and temporal isocortex. This rules out answer A (part of ERC) Figure 3. from Braak H, Bra...
Read 11 tweets
21 Oct
Last week we received over 100 (!) responses on our quiz about which hippocampal subfield accumulates tau pathology earliest in the disease.

#SubfieldWednesday (1/n)
This week we will explain that the correct answer for Alzheimer's disease (but not all types of dementia) is CA1!

#SubfieldWednesday (2/n)
Work from Braak & Braak (1991) showed that CA1 develops tau pathology before the other subfields.

#SubfieldWednesday (3/n) Cartoon drawing of the medi...
Read 9 tweets
8 Oct
Hello subfield-fans! Last week's #SubfieldWednesday topic was the layered composition of the hippocampal subfields. We learned that the subfields contain three major cellular layers which makes them a part of the allocortex.

#SubfieldWednesday (1/n) Table 1 from: Insausti, Ric...
@thomcat992 replied that the hippocampus is archicortex, which is also correct! Archicortex is a type of allocortex.

#SubfieldWednesday (2/n)
Now what about the entorhinal cortex (ERC)? The ERC has six layers, so does that make it neocortex (also known as the isocortex)?

#SubfieldWednesday (3/n)
Read 12 tweets
1 Oct
Better late than never! (It's still Wednesday in some timezones!) This week's #SubfieldWednesday will be a bit briefer than normal.

#SubfieldWednesday (1/n)
Some of you might have been surprised last week when we described the hippocampal subfields as layered structures.

#SubfieldWednesday (2/n)
Even though the hippocampus sometimes gets grouped together with subcortical structures like the thalamus and basal ganglia, the dentate gyrus, CA fields, and subiculum are all part of a special type of cortex called the allocortex!

#SubfieldWednesday (3/n)
Read 7 tweets

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