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17 Dec, 180 tweets, 59 min read
1. A mirrored thread gathering info on potential treatment of COVID-19 with Quercetin & Zinc.
It includes various studies, articles, anecdotal & empirical evidence to help establish a case for its potential anti-viral effects especially when taken early on - by @HighPeaks77
2. Current study by renowned Montreal Researchers in the potential treatment of #COVID19 with Quercetin:
mcgilltribune.com/sci-tech/montr…
- via @ClaraLago1 @Caradelevingne @taylorswift13 @rihanna @AbbyMartin @Polly_Boiko @TomCruise @scarletmonahan @inabster @WHO @NHSuk @UN @UNICEF
3. Study receives 1 million dollar donation to initiate trials in China:
ircm.qc.ca/en/news/lazari… Image
4. More press on the trial: macleans.ca/news/canada/a-… Image
5. Radio interview with the leading researchers, Dr Michel Chrétien and Dr Majambu Mbikay: cbc.ca/player/play/17…
6. Video interview on CBC News:
7. What is #Quercetin? Here is a great article on its nature: benefits, foods, dosage, possible side effects.
healthline.com/nutrition/quer…
- @inabster @HighPeaks77 @zev_dr
8. What is Zinc: Everything You Need to Know -
healthline.com/nutrition/zinc
8a. Bromelain: Dosage, Benefits, and Side Effects - healthline.com/health/bromela…
9. Link to various studies dealing with the benefits of Quercetin, especially its potential against diseases, bacteria & viruses.
10. Quercetin efficacy against SARS - Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003: Small Molecules Blocking Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells - jvi.asm.org/content/78/20/…
11. Study of Quercetin efficacy on Influenza A Virus:
ncbi.nlm.nih.gov/pmc/articles/P…
12. Study of Quercetin efficacy on Ebola:
aac.asm.org/content/60/9/5…
13. Study of Quercetin efficacy on Hepatitis C Virus:
nature.com/articles/srep3…
14. Study of Quercetin on Chronic inflammation & oxidative stress as a major cause of age-related diseases & cancer:
pubmed.ncbi.nlm.nih.gov/19149749/
15. Oncology Reports - Study on suppression of cancer cell growth & inducing cell death in Prostate cancer cells -
Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms & clinical application potential (Review)
spandidos-publications.com/or/33/6/2659 Oncology Reports - Study on...
Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways -
pubmed.ncbi.nlm.nih.gov/32174789/
- @inabster @zev_dr
17. Here is other #Quercetin anti-cancer research on test tube and animal studies on liver, lung, breast, bladder, blood, colon, ovarian, lymphoid, and adrenal cancer cells:
A. ncbi.nlm.nih.gov/pubmed/28677813
B. ncbi.nlm.nih.gov/pubmed/28264020
C. ncbi.nlm.nih.gov/pubmed/24223637
D.
18. Here are Studies of some positive effects of #Quercetin on Alzheimer’s disease and Dementia:
A. ncbi.nlm.nih.gov/pubmed/26904161
B. ncbi.nlm.nih.gov/pubmed/25666032
C.
19. Here are some studies of the effects of #Quercetin on High blood pressure:
A. ncbi.nlm.nih.gov/pubmed/1206570…
B. ncbi.nlm.nih.gov/pubmed/8919657/
C. ncbi.nlm.nih.gov/pubmed/11325801
D.
20. Studies on the effect of Quercetin on combatting aging:
A. ncbi.nlm.nih.gov/pubmed/28966753
B. ncbi.nlm.nih.gov/pubmed/29988130
C.
21. Studies on the effects of #Quercetin to aid blood sugar levels in Diabetics:
A. ncbi.nlm.nih.gov/pubmed/30848564
B. ncbi.nlm.nih.gov/pubmed/30735748
C.
22. Here is a study on the anti-inflammatory properties of Quercetin.
It is specifically important given the potential of inhibiting the high cytokine storm induced by #Covid19, causing major complications like pneumonia etc.
ncbi.nlm.nih.gov/pmc/articles/P…
23.Other study on anti inflammatory properties of Quercetin w/ inhibition of pro inflammatory cytokines: Flavonoid Quercetin Inhibits Proinflammatory Cytokine Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κβ System - cvi.asm.org/content/13/3/3…
24. In test-tube studies, #Quercetin reduced markers of inflammation in human cells, including the molecules tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6). Here are two studies with regard to that:
A. ncbi.nlm.nih.gov/pubmed/20943792
B.
25. An 8-week study in 50 women with rheumatoid arthritis observed that participants who took 500 mg of #Quercetin experienced significantly reduced early-morning stiffness, morning pain, & after-activity pain. They had reduced markers of inflammation: pubmed.ncbi.nlm.nih.gov/27710596/
26. #Quercetin’s anti-inflammatory properties may provide allergy symptom relief. Studies found that it may block inflammatory enzymes and suppress inflammation-promoting chemicals, such as histamine.
A. ncbi.nlm.nih.gov/pubmed/27187333
B. ncbi.nlm.nih.gov/pubmed/18187018
C.
27. Another study showed that taking #Quercetin supplements suppressed peanut-related anaphylactic reactions in mice:
pubmed.ncbi.nlm.nih.gov/20548131/
28. Here is a study with regard to #Quercetin’s efficacy on inhibiting the Zika virus:
biorxiv.org/content/10.110…
29. Possible effects of #Quercetin on SARS-COV-2, otherwise known as #COVID19.
There are various ways Quercetin may be effective in inhibiting the effects of the coronavirus.
30. 1) Blocking Entry of Virus. Supercomputer simulations by University of Tennessee & Oak Ridge National Labs to demonstrate which FDA approved chemical compounds may interfere with the coronavirus binding to cells. Out of 8000, Quercetin came in #5 - chemrxiv.org/articles/prepr…
30a. 1) Blocking Entry of Virus. Supercomputer simulations by University of Tennessee & Oak Ridge National Labs to demonstrate which FDA approved chemical compounds may interfere with the coronavirus binding to cells. Out of 8000, Quercetin came in #5 -
31. More detail:
31a. Recent study showed that SARS-COV-2 may infect lung cells via ACE receptor: biorxiv.org/content/10.110…

Quercetin has been shown to also inhibit ACE receptor in multiple in vitro and in vivo studies: scholar.google.com/scholar?q=Quer…
32. Yet more detail on the mechanism of how Quercetin may block virus entry into cells. Here is the table from the Supercomputer simulation mentioned above:
33. This seems to be the mechanism proposed by the Montreal researchers mentioned above. Here is a piece of the article mentioned above: mcgilltribune.com/sci-tech/montr… Image
34. 2) Quercetin acts as a Zinc Ionophore, allowing Zinc to pass the cell membrane and thereby inhibit the replication of the virus. Here is the study demonstrating this:
pubs.acs.org/doi/full/10.10…
35. This is essentially the same process behind chloroquine/Hydroxychloroquine as they are both Zinc Ionophores. This is one of the leading theories behind their efficacy as anti-viral drugs.
ncbi.nlm.nih.gov/pmc/articles/P…
36. Here is a great video demonstrating how chloroquine/Hydroxychloroquine work as zinc ionophores to inhibit virus replication:
37. As an aside I would like to share two recent documents showing the strong efficacy of Hydroxychloroquine and Zinc in fighting Covid-19.
A) docs.google.com/document/u/0/d…
38. B) Here is the second document on Hydroxychloroquine’s efficacy on treating COVID-19:
docs.google.com/document/d/1O6…
39. Zinc- The following is a study showing Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture:
ncbi.nlm.nih.gov/pmc/articles/P…
40. Here is a trial on the efficacy of Zinc on the common cold: ncbi.nlm.nih.gov/pubmed/15496046
41. More studies on Zinc’s anti viral properties:
A) ncbi.nlm.nih.gov/pubmed/17344507
B) ncbi.nlm.nih.gov/pubmed/16982486
C) ncbi.nlm.nih.gov/pubmed/23775705
D) ncbi.nlm.nih.gov/pubmed/19341987
E) ncbi.nlm.nih.gov/pubmed/15189121
F) ncbi.nlm.nih.gov/pubmed/18279051
G)
42. This is a very detailed explanation on the connection between chloroquine, Zinc & Quercetin & illustrates clearly how they share similar mechanisms.
dadamo.com/dangerous/2020…
43. 3) Another reason why #Quercetin may be effective at combating #COVID19 is due to the fact that it may inhibit the cytokine storm induced by the coronavirus:
ncbi.nlm.nih.gov/pmc/articles/P…
44. 4) Another potential Quercetin anti-Covid-19 mechanism:
45. See this tweet as well: insight.jci.org/articles/view/…
46. And this tweet:
47. Linking articles & videos related to #Quercetin’s potential to fight COVID-19.
48. Can quercetin help us to avoid the threat of coronavirus infection? | Journal Online
journal.com.ph/news/world/bre…
49. Quercetin can help to combat #COVID19 - regenexx.com/blog/coronavir…
50. Combating Covid-19 with Zinc & #Quercetin:
51. Quercetin vs CoVid19 (Powerful anti-viral properties of this unique nutrient):
thenutritionwatchdog.com/quercetin-vs-c…
52. Can #Quercetin Treat Coronavirus Infection? supplementclarity.com/does-quercetin…
53. Mast Cell Activation & Coronavirus: Is #Quercetin Effective Against #COVID19?
mastcelldisease.com/mast-cell-acti…
54. Quercetin as Zinc Ionophore & #COVID19 Outpatient Management By DrBeen Medical Lectures:
55. MedCram Video Update #35- This was one of the first mentions on the potential of Quercetin to act as a Zinc Ionophore like Hydroxychloroquine to inhibit virus replication, thereby potentially acting as a treatment for SARS-COV-2/ #COVID19:
56. Eastern Virginia Medical School Critical Care #COVID19 Management Protocol & earlier treatment recommendation/ They recommend Quercetin 250mg-500mg each day.
evms.edu/media/evms_pub… Image
57. It also part of the daily regimen by Harvard Researcher, David Sinclair. blog.daveasprey.com/wp-content/upl… Image
58. Anecdotal evidence of people who took Quercetin/Zinc as a remedy for #COVID19. Thank you @ScarofOdysseusfor collecting many of these cases and your ongoing work on providing anecdotal support to this potential treatment.
58a. Over 220 first-person accounts of how Quercetin +/or Zinc may improve early Covid19 symptoms (confirmed + unconfirmed). Zinc inhibiting viral replication, Quercetin possibly acting as Zinc ionophore, S-protein blocker, IL-6 and furin antagonist -
59.
Symptoms went away in 2 days on taking Quercetin (500mg BID) & Emergen-c (1 per day) w/ Vit-C, D & Zinc Down pointing backhand index. Subsequently switched to Qct+Bromelain. #QuercetinZinc Image
60. <deleted>
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67. <deleted> - will carry on publishing anecdotals - very tedious bu necessary...
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85. This is the same one as #81
86. This doctor got better after using a cocktail of supplements that included #Quercetin.
theglobeandmail.com/life/first-per… Image
87.
88. I found some Anecdotal Quercetin cases on YT comments as well.... Image
89. ImageImage
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99. Here is a new study in Turkey that will study the prophylaxis and treatment of Quercetin for Covid-19:
clinicaltrials.gov/ct2/show/NCT04…
100.

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102. This is a follow up detailed report of an earlier report:
<deleted>
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106. Very interesting article:
107. Image
108. Great thread on Quercetin’s potential immunity response:
109. New trial underway for Isoquercetin for high risk prevention in #COVID19:
sph.umich.edu/biostat/covid1…
110. New trial in Canada by Dr Michel Chretien’s team:
icav-citav.com/icav_news/isoq…
111. Another report where #Quercetin helped:
112. <deleted>
113. Terrific Paper!

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19) #Quercetin #COVID19
frontiersin.org/articles/10.33…
via @sup_sam
114. Early Clinical trial data looks promising for Quercetin:
115.
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117. Another positive Quercetin report:
118. Very important thread below -
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124. New Quercetin Trial in Saudi Arabia:
Saudi Arabian clinical trial of queretin, zinc, bromelain, and vitamin C for treating COVID-19 ichgcp.net/clinical-trial… - via @sup_sam
124b. New Quercetin Trial in Saudi Arabia:
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136. Great summary!
A good summary of the antiviral effects of quercetin and related compounds. naturopathiccurrents.com/sites/default/…
137. Another great review!

A good review article discussing the potential for flavonoids in treating coronavius infection. ncbi.nlm.nih.gov/pmc/articles/P…
137b. A good review article discussing the potential for flavonoids in treating coronavius infection. ncbi.nlm.nih.gov/pmc/articles/P…
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140. Quercetin and Zinc, part of the official prophylaxis protocol recommended by Dr Zelenko
@zev_dr :
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Shay Robinson @loveprophecy
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My younger brother had covid19 and recovered.

I ordered supplements for him and sent the following suggestions (dosage may vary based on age/weight):

"You need
75 mg zinc (stop taking this once you feel better)
600 mg nac
2000 mg quercetin
149a. 50,000 iu vitamin d3 (once a week or 10,000 iu daily, or an hour of so of sunlight 5 days a week)
100 mcg vitamin k2 per 10,000 iu of vitamin d3 (to prevent calcification)"

My mom also gave him curcumin capsules and made ginger tea for him.
149b. Watch Medcram Update 59:


- via @compsciman @Datin_TripleD
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152. Update on Montreal Isoquercetin Trial:
153. Great to see Quercetin getting into the mainstream news:
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Another computer-aided molecular screening in Europe (alongside the one at UT/ORNL) in which quercetin also ranked highly. via @aronro
Supported by evidence of significant clinical benefits
doi.org/10.1016/j.jsbm…
Over-the-Counter remedy for prevention & therapy
doi.org/10.3390/biomed…
Vitamin D & Quercetin inhibit viral entry & Vitamin D + QCT + Estradiol interfere with functions of 26/27 (96%) virus proteins
Over-the-Counter remedy for prevention & therapy
doi.org/10.3390/biomed…
Vitamin D & Quercetin inhibit viral entry & Vitamin D + QCT + Estradiol interfere with functions of 26/27 (96%) virus proteins
Supported by evidence of significant clinical benefits
A path to clinical trial: Quercetin + Vitamin D + Estradiol alter expression of 244 of 332 (73%) SARS-CoV-2 targets in human cells, thus interfering with functions of 96% (26 of 27) SARS-CoV-2 proteins.
doi.org/10.3390/biomed…
TRIPARTITE COMBINATION FOR PANDEMIC MITIGATION
Credits @zev_dr @gglinskii @sup_sam @HighPeaks77 & all wonderful people Rt'd or mentioned in this thread, patients, MDs & their friends - may Hashem/G-d/Allah heals you & showers you with Mercy...
Also this thread -
#COVIDー19 tips
by JoiningUnrelatedDots @Mareeswj
Earlier I posted an antiviral combo which I believe is a successful treatment against #SARSCoV2 & similar pathogens, dosage varies depending on severity - posted here -

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