Thread by @VivekSubbiah

🚨⭐️ By popular demand 👉The Top 10 clinical publications in Oncology in 2020 (In no particular order). Some important papers bundled + Additional 5 more papers representing major advances in the field @OncoAlert

1. Pembrolizumab led to significantly longer progression-free survival vs chemotherapy as first-line therapy for MSI-H–dMMR metastatic colorectal cancer 👉Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer @NEJM @agrothey nejm.org/doi/full/10.10…

2. Most children with neurofibromatosis type 1 and inoperable plexiform neurofibromas had durable tumor shrinkage and clinical benefit from selumetinib 👉Selumetinib in Children with Inoperable Plexiform Neurofibromas @NEJM nejm.org/doi/full/10.10…

3. Vaccine prevents cancer👉Quadrivalent HPV vaccination was associated with a substantially reduced risk of invasive cervical cancer at the population level 👉HPV Vaccination and the Risk of Invasive Cervical Cancer @NEJM nejm.org/doi/full/10.10…

4. Finally the undruggable KRAS is druggable👉 KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors @NEJM @DavidHongMD nejm.org/doi/full/10.10…

5. Selective RET inhibitor alter the landscape of RET cancers👉 Efficacy of Selpercatinib in RET Fusion–Positive & thyroid cancer ( COI: Senior/co-senior author in both papers) @NEJM bit.ly/3aWQOZx nejm.org/doi/full/10.10…

6. GU👉Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma @PGrivasMDPhD + OS Analysis of the PROfound Study: @myESMO @neerajaiims
@NEJM
– Link: nejm.org/doi/full/10.10… bit.ly/3aWRwGb

7. Cholangiocarcinoma. Pemigatinib for FGFR & Dabrafenib+ Trametinib BRAFV600 + cholangiocarcinoma. Two @TheLancetOncol publications. ( COI: PI of BRAF trial) bit.ly/3hyCFCM thelancet.com/journals/lanon…

8. From a tweet to @TheLancet in 10 weeks. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study @hemoncwarner @DrChoueiri @ADesaiMD @PGrivasMDPhD @corrie_painter thelancet.com/journals/lance…

9. Anti-biotic therapy reduces risk of cancer 👉 Family History of Gastric Cancer and Helicobacter pylori Treatment @NEJM @ShaalanBeg @cancerassassin1 @MiteshBorad nejm.org/doi/full/10.10…

10. The ADAURA study. Maybe controversial but still a major advance in EGFR NSCLC & opens door for many other adjuvant studies 👉Osimertinib in Resected EGFR-Mutated Non–Small-Cell Lung Cancer @NEJM @JackWestMD @n8pennell @StephenVLiu nejm.org/doi/full/10.10…

11. EZH2 inhibition for epithelioid sarcoma and follicular lymphoma 2 @TheLancetOncol papers + editorial bit.ly/3aWWjr9 bit.ly/38MF6xT thelancet.com/journals/lanon…

12. Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study thelancet.com/journals/lanon…

13. Capmatinib & Teoptinib in MET Exon 14–Mutated or MET-Amplified Non–Small-Cell Lung Cancer @NEJM @StephenVLiu nejm.org/doi/full/10.10… nejm.org/doi/full/10.10…

14. The Effect of Advances in Lung-Cancer Treatment on Population Mortality @NEJM nejm.org/doi/full/10.10…

15. Pfizer + Moderna #COVID19 vaccine studies. Not oncology but will prevent COVID19 infection in patients with cancer in the future + Protect #healthcareworkers + researchers in Cancer @oncoalert nejm.org/doi/full/10.10… nejm.org/doi/full/10.10…