Earlier this year, @Scient_Art collaborated with us to produce one of the first detailed 3D models of the #SARSCoV2 virus particle. To round off 2021 she's updated her model, and it looks great (1/N) Image
... the first model drew heavily on existing work on related viruses (SARS-CoV-1 and MHV). The updated model has an improved representation of the spike protein, building on the detailed model from @RommieAmaro's lab (pubs.acs.org/doi/10.1021/ac…) (2/N) Image
The spacing and flexing of the spikes was also updated based on cryoEM data, particularly from the labs of @BriggsGroup (disq.us/t/3r34r8p) and @drlisai (doi.org/10.1016/j.cell…) (3/N) Image
As well as improving the rendering, @Scient_Art has produced some videos, one showing the flexibility of the virus particle, with the spike particles drifting and flexing... (4/N)
... and another more detailed ones with the structures labelled and a cutaway view of the interior (5/N)
@Scient_Art has written a great summary of how she did all this (with references) at her website: scientart.com (6/N) Image
All models are available through Creative Commons (CC-BY NC Annabel Slater / MRC-University of Glasgow Centre for Virus Research).
We hope they're useful for you!
Details of the earlier models can also be found here:
(7/ENDS) @CVRinfo #scicomm #sciart

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More from @CVRHutchinson

18 Jun 20
We’ve just had a paper published and I would like to tell you a story about people in science being nice to each other – a thread cell.com/cell/fulltext/…
This is a large, collaborative effort – 54 authors across multiple institutions, led @MountSinaiNYC and @CVRinfo. But the science in the story is quite simple (and you can read it in the paper), so I’ll explain it quickly before telling a different story (which you cannot)
Briefly, here’s the science of it. THE BACKGROUND: (i) Viruses need to make mRNA that host ribosomes can translate into proteins Baltimore classification of viruses
Read 35 tweets
27 May 20
Thread! It’s great to have been able to collaborate with @Scient_Art on a detailed model of the #SARS-CoV-2 virus particle, the cause of #COVID-19, using methods we’ve developed with @GSofASimVis @GSofA and @CVRinfo #scicomm #sciart (1/13) Image
These have been used by @snjasim to illustrate an @UKRI_News article on ‘Getting to know the new coronavirus’ coronavirusexplained.ukri.org/en/article/cad… (2/13)
Thanks to @Scient_Art and @GlasgowLifeSci you can explore #SARS-CoV-2 in 3D on @Sketchfab here: sketchfab.com/3d-models/sars… (3/13) Image
Read 13 tweets

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