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Hutchinson Lab Profile picture
Hutchinson Lab
@CVRHutchinson
Molecular virology lab | posts from Ed Hutchinson (he/his) @CVRinfo @UofGlasgow @The_MRC. Occasional updates here but increasingly @socialinfluenza.bsky.social
Jun 24, 2024 • 9 tweets • 2 min read
Some interesting reading on viruses in milk 🐄🦠
Recently we and others looked at the effects of pasteurisation on H5N1 in milk (very effective) and the risks of 'raw' milk (very risky).
But what about unpasteurised cheese ? The experiment sounded like microbiological chaos... A cheese board showing various soft cheeses ... and to be clear we haven't done it ourselves, partly because everyone in the lab looks horrified whenever I suggest it. But people have done it in the past for another bovine virus, foot and mouth disease: ...sciencedirect.com/science/articl…
Jun 3, 2024 • 11 tweets • 4 min read
🚨New Pre-Print🚨
With #H5N1 #flu shed in cow’s milk in the USA, we worked with @cvrinfo, @roslininstitute, @Pirbright_Inst & @APHAgovuk to ask if pasteurisation would make it safe
🐮🦠🥛🌡️
TL;DR: pasteurisation’s effective, raw milk can be infectious
medrxiv.org/content/10.110… There are lots of good reasons to pasteurise milk, which is done by heating at 63C for a long time or 72C quickly. But we hadn’t previously had to worry about influenza in milk
Would pasteurisation work here too? Fresian cows
Feb 10, 2023 • 23 tweets • 13 min read
In a new paper led by @annasimsbiol, we find that influenza infections divide your throat into tiny territories, and ask:
why don’t these viruses want to be friends?

Paper doi.org/10.1371/journa…
Commentary doi.org/10.1371/journa…

A 🧵 An image showing two infected regions, one green and one mag Some background: If two viruses get into the same cell, they can genes exchange (basically they can breed). This is really important for viral evolution. A dramatic example is when different strains of influenza A virus (IAVs) use coinfection to generate pandemic strains A schematic showing a green and magenta virus coinfecting a
Sep 15, 2022 • 9 tweets • 8 min read
🚨New pre-print!🚨
biorxiv.org/content/10.110…
Viruses are very small things with very big effects. During the #SARSCoV2 pandemic, tiny changes in molecular biology had huge impacts on people’s lives. How could we communicate about this clearly?
🦠#scicomm #sciart🦠
(1/9) In a new study with @CVRinfo @GSofASimVis and @COGUK_ME, @sarahiannucci1 explains how she used animations and interactive visualisations to help explain the threat of #SARSCoV2 variants of concern (#VOCs; 2/9)
Jun 9, 2022 • 17 tweets • 10 min read
In a new preprint led by @annasimsbiol, we ask:
Why Don’t These Viruses Want to be Friends?
A 🧵...
biorxiv.org/cgi/content/sh… An image showing two infected regions, one green and one mag Coinfection is an important aspect of viral evolution. If two viruses can get into the same cell, they can undergo genetic exchange. A dramatic example of this is when different strains of influenza A virus (IAVs) use coinfection to generate novel pandemic strains A schematic showing a green and magenta virus coinfecting a
Sep 21, 2021 • 11 tweets • 5 min read
A quick Tweetorial about our new paper with the #BoutellLab, which @CharmanMatthew led during his PhD @CVRinfo

Alternative title: ‘Why are virologists’ cells stupid and does this matter?’ 🧵 (1/N) If you work with human influenza viruses in the lab you most likely grow them in MDCK cells, or possibly MDBK cells, or maybe A549 cells if you are fussy enough to want a cell line that comes from (a) the right organ system and (b) the right species of animal (2/N)
Dec 31, 2020 • 7 tweets • 5 min read
Earlier this year, @Scient_Art collaborated with us to produce one of the first detailed 3D models of the #SARSCoV2 virus particle. To round off 2021 she's updated her model, and it looks great (1/N) Image ... the first model drew heavily on existing work on related viruses (SARS-CoV-1 and MHV). The updated model has an improved representation of the spike protein, building on the detailed model from @RommieAmaro's lab (pubs.acs.org/doi/10.1021/ac…) (2/N) Image
Jun 18, 2020 • 35 tweets • 15 min read
We’ve just had a paper published and I would like to tell you a story about people in science being nice to each other – a thread cell.com/cell/fulltext/… This is a large, collaborative effort – 54 authors across multiple institutions, led @MountSinaiNYC and @CVRinfo. But the science in the story is quite simple (and you can read it in the paper), so I’ll explain it quickly before telling a different story (which you cannot)
May 27, 2020 • 13 tweets • 13 min read
Thread! It’s great to have been able to collaborate with @Scient_Art on a detailed model of the #SARS-CoV-2 virus particle, the cause of #COVID-19, using methods we’ve developed with @GSofASimVis @GSofA and @CVRinfo #scicomm #sciart (1/13) Image These have been used by @snjasim to illustrate an @UKRI_News article on ‘Getting to know the new coronavirus’ coronavirusexplained.ukri.org/en/article/cad… (2/13)