psychedelicinsights.com/blog/
The Top 10 Psilocybin Research Papers of 2020
- FS Barrett, MK Doss, ND Sepeda, et al. – Emotions and brain function are altered up to one month after a single high dose of psilocybin. @FredBarrettPhD 1/10
SB Goldberg, BT Pace, CR Nicholas, et al. – The experimental effects of psilocybin on symptoms of anxiety and depression: A meta-analysis. “meta-analysis of studies using psilocybin along with behavioral interventions to treat elevated symptoms of anxiety and depression.” 2/10
GI Agin-Liebes, T Malone, MM Yalch, et al. – Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer. “follow-up approx 3.2 and 4.5 years later, w/ 15 of the 16 participants still alive” 3/10
F Blei, S Dörner, J Fricke, et al. – Simultaneous production of psilocybin and a cocktail of β‐carboline monoamine oxidase inhibitors in “magic” mushrooms “paper was chosen for Psychedelic Science Review’s 2020 Editor’s Choice Award for best study on psychedelics and nature” 4/10
J Sloshower, J Guss, R Krause, et al. – Psilocybin-assisted therapy of major depressive disorder using Acceptance and Commitment Therapy as a therapeutic frame “lays out how to combine therapy using antidepressant medication (like psilocybin) w/evidence-based psychotherapy” 5/10
LJMertens, MBWall, LRoseman, et al Therapeutic mechanisms of psilocybin: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression
“↗️amygdala activation in participants day after psilocybin tx” 6/10
NL Mason, KPC Kuypers, F Müller, et al. – Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin. Good One! 7/10
MK Madsen, PMD Fisher, DS Stenbæk, et al. Single psilocybin dose is assoc. w/ long-term ↗️mindfulness, preceded by proportional change in neocortical 5-HT2A receptor binding
1st molecular neuroimaging study examining underlying mechanisms behind long term efx of psilocybin 8/10
KH Preller, P Duerler, JB Burt, et al. – Psilocybin induces time-dependent changes in global functional connectivity “deepen our understanding of the mechanism of action of psychedelic compounds” 9/10
N Milne, P Thomsen, N Malgaard Knudsen, et al. – Metabolic engineering of Saccharomyces cerevisiae for the production of psilocybin and related tryptamine derivatives 10/10 .... there are 4 more studies cited in the blog post.

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More from @drrickbarnett

29 Dec 20
Fascinating @JAMANetworkOpen article on #schizophrenia treatments .. limits of #pharmacotherapy and benefits of added #psychosocial treatments. Here’s a snippet with eye towards how this relates to treating other mental health conditions. 1/4 @division_55
jamanetwork.com/journals/jama/…
“Among responders (to meds), some are able to function independently, others remain disabled despite control of their psychotic symptoms...residual disability attributed to negative symptoms and cognitive deficits, which are less responsive than psychosis to drug treatments.” 2/4
“persistence of disability and ↘️ quality of life, poor medication adherence necessitated delivery of evidence-based psychosocial services, including CBT; family psychoeducation; social skills training; assertive community treatment; and assistance w/work, education, housing” 3/4
Read 4 tweets
16 Dec 20
I got a degree in Clinical Psychopharmacology after getting my license to practice as a Doctor of Psychology because I started working w/older adults who struggled emotionally AND were prescribed a TON of meds. Something wasn’t right. I had to know more. @division_55 1/7
Not only did i learn basic clinical medicine, pathophysiology, review of systems, lab workups, etc.. but also learned about effects of drug-drug, drug-disease interactions on mood, mind, behaviors, and stress. One tool i still find useful is the #BeersCriteria (not etoh..lol) 2/7
Here’s a link to 2020 Updated from 2015 guidelines from @aafp aafp.org/afp/2020/0101/… Inappropriate Medication Use in Older Adults. If you have an older adult in your life, check their med-list. You’ll be surprised. Or maybe not. Here are “key points of practice”: 3/7
Read 7 tweets
15 Dec 20
Gonna highlight some of this article in a thread. Thank you @headdock et al. This is a must read for those interested in drug death crisis. #polypharmacy and #polydrug is the problem #notjustopioids
dovepress.com/the-polysubsta… @apadivision50 @division_55 @APADiv28
1/5
“It is time to take the blinders off. It is time for everyone – clinicians, legislators, insurers, media, family members, and all others, including the general public – to recognize the complexities of the issues surrounding the crisis of polysubstance overdose deaths.” 2/5
“The terms “opioid-induced respiratory depression” and “opioid-overdose death” are outdated, as they fail to reflect current realities and only further continue the errant notion of simplicity. They should be abandoned for the more accurate and clinically-helpful terms” like..3/5
Read 5 tweets
26 Nov 20
#gratitude thread 1/12
“Appreciation is a wonderful thing. It makes what is excellent in others belong to us as well.” Voltaire
#grateful for classics @CIIS_SF
#gratitude thread 2/12
“When eating fruit, remember the one who planted the tree.” Vietnamese Proverb @BreneBrown
@grateful for cultures
#gratitude thread 3/12
“Got no checkbooks, got no banks, still I’d like to express my thanks. I got the sun in the morning and the moon at night.” Irving Berlin @PolarisInsight
#grateful for music
Read 13 tweets
27 Aug 20
“Of potential harms of getting distracted by a more progressive model of mental healthcare by polarized ideas is that it could prevent people from seeking care that they may want, or invalidate experiences of people who have been helped by psychiatry” vice.com/en_us/article/… 1/4
@jonathanstea @JonathanShedler @AllenFrancesMD @VICENews “By claiming that mental illness doesn't exist at all, anti-psychiatry could also lead us astray from much-needed reform within psychiatry, precisely because it seeks not to improve psychiatry, but to tear it down.” 2/4
“There are useful discussions and summaries on Mad in America. Importantly, there are also real experiences and trauma behind many of the posts that discuss the harms patients suffer from psychiatry.” @Mad_In_America @sandysteingard 3/4
Read 5 tweets
25 Aug 20
#medtwitter #psychtwitter friends and less than friendly, please stop playing turf wars with scope of practice issues. Now is the time to collaborate NOT create more conflict. @CatoInstitute cato.org/blog/health-ca… @division_55 @APADiv19 @APA 1/5
"For decades state legislators have witnessed turf battles among various health care professions. Nurse practitioners and physicians’ assistants, for example, seek to practice independently of physicians and to expand their scope of practice to meet their level of training" 2/5
"This is usually met with resistance from medical doctors who argue NPs and PAs lack the necessary training to safely provide care beyond a narrowly‐​defined scope. In most states doctorate‐​level clinical psychologists are not allowed to prescribe psychiatric medications.." 3/5
Read 6 tweets

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